SHP-1 Phosphatase Is a Critical Regulator in Preventing Natural Killer Cell Self-Killing

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Mahmood, Sajid ^a   Kanwar, Namita ^b   Tran, Jimmy ^a   Zhang, Man li ^a   Kung, Sam K P ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; PROTEIN TYROSINE PHOSPHATASE SHP 1;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL FATE; CELL FUNCTION; CELL KILLING; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME REGULATION; GENE SILENCING; IN VITRO STUDY; LENTIVIRINAE; MOLECULAR IMAGING; MOLECULAR RECOGNITION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; CELL DEGRANULATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; COMPUTER SYSTEMS; CYTOTOXICITY, IMMUNOLOGIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; IMAGING, THREE-DIMENSIONAL; IMMUNOASSAY; INTERLEUKIN-2; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6;

EID: 84865617411     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044244     Document Type: Article

References (46)

1. Sentman CL, Barber MA, Barber A, Zhang T, (2006) NK cell receptors as tools in cancer immunotherapy. Adv Cancer Res 95: 249-292.
2. Biassoni R, Ugolotti E, De Maria A, (2010) Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses. Self Nonself 1: 103-113.
3. Lanier LL, (1998) NK cell receptors. Annu Rev Immunol 16: 359-393.
4. Moretta L, Bottino C, Cantoni C, Mingari MC, Moretta A, (2001) Human natural killer cell function and receptors. Curr Opin Pharmacol 1: 387-391.
5. Yokoyama WM, Plougastel BF, (2003) Immune functions encoded by the natural killer gene complex. Nat Rev Immunol 3: 304-316.
6. Bezman NA, Cedars E, Steiner DF, Blelloch R, Hesslein DG, et al. (2010) Distinct requirements of microRNAs in NK cell activation, survival, and function. J Immunol 185: 3835-3846.
7. Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, et al. (2008) Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. Blood 112: 2869-2877.
8. Long EO, (2008) Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev 224: 70-84.
9. Abeyweera TP, Merino E, Huse M, (2011) Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol 192: 675-690.
10. Ljutic B, Carlyle JR, Filipp D, Nakagawa R, Julius M, et al. (2005) Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors. J Immunol 174: 4789-4796.
11. Binstadt BA, Brumbaugh KM, Leibson PJ, (1997) Signal transduction by human NK cell MHC-recognizing receptors. Immunol Rev 155: 197-203.
12. Long EO, (1999) Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17: 875-904.
13. Ortaldo JR, Young HA, (2005) Mouse Ly49 NK receptors: balancing activation and inhibition. Mol Immunol 42: 445-450.
14. Lanier LL, (2008) Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol 9: 495-502.
15. Babic M, Pyzik M, Zafirova B, Mitrovic M, Butorac V, et al. (2010) Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo. J Exp Med 207: 2663-2673.
16. Tran J, Mahmood S, Carlyle JR, Kung SK, (2010) Altering the specificity of NK:target cell interactions by genetic manipulation of NK receptor expression on primary mouse NK cells. Vaccine 28: 3767-3772.
17. Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM, (1999) Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. J Immunol 162: 1318-1323.
18. Lowin-Kropf B, Kunz B, Beermann F, Held W, (2000) Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1. J Immunol 165: 1314-1321.
19. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, et al. (1997) Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med 185: 673-684.
20. Koo GC, Manyak CL, Dasch J, Ellingsworth L, Shultz LD, (1991) Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice. J Immunol 147: 1194-1200.
21. Kozlowski M, Mlinaric-Rascan I, Feng GS, Shen R, Pawson T, et al. (1993) Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med 178: 2157-2163.
22. Tran J, Kung SK, (2007) Lentiviral vectors mediate stable and efficient gene delivery into primary murine natural killer cells. Mol Ther 15: 1331-1339.
23. Orr MT, Lanier LL, (2011) Inhibitory Ly49 receptors on mouse natural killer cells. Curr Top Microbiol Immunol 350: 67-87.
24. Zafirova B, Wensveen FM, Gulin M, Polic B, (2011) Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci 68: 3519-3529.
25. Alter G, Malenfant JM, Altfeld M, (2004) CD107a as a functional marker for the identification of natural killer cell activity. Journal of immunological methods 294: 15-22.
26. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, et al. (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. Journal of immunological methods 281: 65-78.
27. Peters PJ, Borst J, Oorschot V, Fukuda M, Krahenbuhl O, et al. (1991) Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. The Journal of experimental medicine 173: 1099-1109.
28. Aktas E, Kucuksezer UC, Bilgic S, Erten G, Deniz G, (2009) Relationship between CD107a expression and cytotoxic activity. Cellular immunology 254: 149-154.
29. Zaritskaya L, Shurin MR, Sayers TJ, Malyguine AM, (2010) New flow cytometric assays for monitoring cell-mediated cytotoxicity. Expert review of vaccines 9: 601-616.
30. Kung SK, Miller RG, (1995) The NK1.1 antigen in NK-mediated F1 antiparent killing in vitro. J Immunol 154: 1624-1633.
31. Karlhofer FM, Yokoyama WM, (1991) Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1.1 antigen. IL-2-activated NK cells possess additional specific stimulation pathways. J Immunol 146: 3662-3673.
32. Vitale M, Bottino C, Sivori S, Sanseverino L, Castriconi R, et al. (1998) NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J Exp Med 187: 2065-2072.
33. Regunathan J, Chen Y, Wang D, Malarkannan S, (2005) NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Blood 105: 233-240.
34. Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, et al. (2001) Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). Immunol Rev 181: 223-233.
35. Ndhlovu LC, Lopez-Verges S, Barbour JD, Jones RB, Jha AR, et al. (2012) Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood 119: 3734-3743.
36. Koh CY, Blazar BR, George T, Welniak LA, Capitini CM, et al. (2001) Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood 97: 3132-3137.
37. Yu YY, George T, Dorfman JR, Roland J, Kumar V, et al. (1996) The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. Immunity 4: 67-76.
38. Kung SK, (2010) Introduction of shRNAs into primary NK cells with lentivirus. Methods Mol Biol 612: 233-247.
39. Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS, (2009) Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation. J Immunol 183: 3219-3228.
40. Gunturi A, Berg RE, Forman J, (2003) Preferential survival of CD8 T and NK cells expressing high levels of CD94. J Immunol 170: 1737-1745.
41. Lunemann A, Tackenberg B, DeAngelis T, da Silva RB, Messmer B, et al. (2011) Impaired IFN-gamma production and proliferation of NK cells in multiple sclerosis. Int Immunol 23: 139-148.
42. Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, et al. (2011) Innate or adaptive immunity? The example of natural killer cells. Science 331: 44-49.
43. Yadav PK, Chen C, Liu Z, (2011) Potential role of NK cells in the pathogenesis of inflammatory bowel disease. J Biomed Biotechnol 2011: 348530.
44. Purdy AK, Campbell KS, (2009) SHP-2 expression negatively regulates NK cell function. J Immunol 183: 7234-7243.
45. Yusa S, Catina TL, Campbell KS, (2002) SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. J Immunol 168: 5047-5057.
46. Kung SK, An DS, Chen IS, (2000) A murine leukemia virus (MuLV) long terminal repeat derived from rhesus macaques in the context of a lentivirus vector and MuLV gag sequence results in high-level gene expression in human T lymphocytes. J Virol 74: 3668-3681.