A Novel MCPH1 Isoform Complements the Defective Chromosome Condensation of Human MCPH1-Deficient Cells

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Gavvovidis, Ioannis ^a,b   Rost, Isabell ^a   Trimborn, Marc ^c   Kaiser, Frank J ^d   Purps, Josephine ^c   Wiek, Constanze ^e   Hanenberg, Helmut ^e,f   Neitzel, Heidemarie ^c   Schindler, Detlev ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF LÜBECK   (Germany)

^e UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^f INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; HISTONE H2AX; MCPH1 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE PROGRESSION; CENTROSOME; CHROMOSOME CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; EXON; FETUS; FLUORESCENCE MICROSCOPY; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MICROCEPHALY; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PREMATURE CHROMOSOME CONDENSATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF;

AMINO ACID MOTIFS; CELL CYCLE; CELL NUCLEUS; CENTROSOME; CHROMATIN; CHROMOSOMES; EXONS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MODELS, GENETIC; MUTATION; NERVE TISSUE PROTEINS; PEPTIDES; PROTEIN ISOFORMS; RADIATION, IONIZING; RNA, MESSENGER; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84865606355     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040387     Document Type: Article

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