A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

Journal of Molecular Biology

Volumn 395, Issue 5, 2010, Pages 908-915

  Richards, Mark W ^a   Leung, Justin W C ^b   Roe, S Mark ^a   Li, Kaiyi ^c   Chen, Junjie ^b   Bayliss, Richard ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

BRCT domain; Mcph1; microcephaly; premature chromosome condensation; X ray crystallography

Indexed keywords

BRCA1 PROTEIN; GENE PRODUCT; MICROCEPHALIN; PHOSPHATE; PHOSPHOPROTEIN; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ISOLATION; CHROMOSOME CONDENSATION; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; GENE MUTATION; HUMAN; HYDROPHOBICITY; MICROCEPHALY; NONHUMAN; PHENOTYPE; PREMATURE CHROMOSOME CONDENSATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

EID: 73649124536     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.11.029     Document Type: Article

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