Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Bezerra, Gustavo Arruda ^a   Dobrovetsky, Elena ^b   Dong, Aiping ^b   Seitova, Almagul ^b   Crombett, Lissete ^b   Shewchuk, Lisa M ^d   Hassell, Annie M ^d   Sweitzer, Sharon M ^d   Sweitzer, Thomas D ^d   McDevitt, Patrick J ^d   Johanson, Kyung O ^d   Kennedy Wilson, Karen M ^d   Cossar, Doug ^b   Bochkarev, Alexey ^b   Gruber, Karl ^a   Dhe Paganon, Sirano ^b,c  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DIPEPTIDYL PEPTIDASE; HISTIDINE; HYDROLASE; PROLINE DIPEPTIDASE; SERINE;

ARCHITECTURAL BARRIER; ARTICLE; CATALYSIS; CROSS REACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; PROTEIN FAMILY;

AMINO ACIDS; ANIMALS; BASE SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; DIMERIZATION; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; EVOLUTION, MOLECULAR; HUMANS; INSECTS; MOLECULAR SEQUENCE DATA; PROLINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 84865600129     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043019     Document Type: Article

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