Synthesis and biological evaluation of homopiperazine derivatives with β-aminoacyl group as dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6525-6529

  Ahn, Jin Hee ^a   Park, Woul Seong ^b   Jun, Mi Ae ^a   Shin, Mi Sik ^a   Kang, Seung Kyu ^a   Kim, Ki Young ^a   Rhee, Sang Dal ^a   Bae, Myung Ae ^a   Kim, Kwang Rok ^a   Kim, Sung Gyu ^c   Kim, Sun Young ^c   Sohn, Sang Kwon ^c   Kang, Nam Sook ^a   Lee, Jie Oh ^d   Lee, Duck Hyung ^b   Cheon, Hyae Gyeong ^a   Kim, Sung Soo ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Sogang University   (South Korea)

^c Yungjin Pharm Co Ltd   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Diabetes; Dipeptidyl peptidase IV; Homopiperazine; Inhibitor

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; HEXAHYDRO 1,4 DIAZEPINE DERIVATIVE; PIPERAZINE DERIVATIVE; SITAGLIPTIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HUMAN; IC 50; INHIBITION KINETICS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP3A; DIABETES MELLITUS; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PIPERAZINES; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 56249143071     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.076     Document Type: Article

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