Non-invasive imaging in coronary artery disease including anatomical and functional evaluation of ischaemia and viability assessment

British Journal of Radiology

Volumn 84, Issue SPEC. ISSUE 3, 2011, Pages

  Pakkal, M ^a   Raj, V ^a   McCANN, G P ^a  

^a UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; NITROGEN 13; OXYGEN 15; RUBIDIUM 82; TETROFOSMIN TC 99M; THALLIUM 201;

ACUTE CORONARY SYNDROME; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; ARTICLE; ATHEROSCLEROTIC PLAQUE; CARDIAC IMAGING; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR MORTALITY; COMPARATIVE STUDY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTRAST ECHOCARDIOGRAPHY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY CALCIUM SCORE; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ELECTROCARDIOGRAM; FUNCTIONAL ASSESSMENT; HEART FUNCTION; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; ISCHEMIC HEART DISEASE; MAGNETIC RESONANCE ANGIOGRAPHY; MORBIDITY; MYOCARDIAL PERFUSION IMAGING; NON INVASIVE PROCEDURE; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRESS ECHOCARDIOGRAPHY; BLOOD VESSEL CALCIFICATION; COMPUTER ASSISTED TOMOGRAPHY; ECHOCARDIOGRAPHY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; REVIEW; THORAX PAIN;

CHEST PAIN; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY STENOSIS; ECHOCARDIOGRAPHY; HUMANS; MAGNETIC RESONANCE IMAGING; MYOCARDIAL PERFUSION IMAGING; POSITRON-EMISSION TOMOGRAPHY; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; VASCULAR CALCIFICATION;

EID: 84865599977     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/50903757     Document Type: Article

References (117)

1. Nilsson S, Scheike M, Engblom D, Karlsson LG, Mölstad S, Akerlind I, et al. Chest pain and ischaemic heart disease in primary care. Br J Gen Pract 2003;53:378-82.
2. Goodacre S, Cross E, Arnold J, Angelini K, Capewell S, Nicholl J. The health care burden of acute chest pain. Heart 2005;91:229-30.
3. British Heart Foundation. UK coronary heart disease statistics 2009-10. London, UK: BHF; 2009.
4. National Institute for Health and Clinical Excellence. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin (clinical guideline 95), 2010. Available at: www. nice.org.uk/guidance/CG95.
5. Braunwald E. Control of myocardial oxygen consumption: physiologic and clinical considerations. Am J Cardiol 1971;27:416-32.
6. Crossman DC The pathophysiology of myocardial ischaemia. Heart 2004;90:576-80.
7. Nesto RW, Kowalchuk GJ. The ischemic cascade: temporal sequence of hemodynamic, electrocardiographic and symptomatic expressions of ischemia. Am J Cardiol 1987;59:23C-30C
8. Verani MS. Pharmacological stress with adenosine for myocardial perfusion imaging. Semin Nucl Med 1991; 21:266-72.
9. Paetsch I, Jahnke C, Wahl A, Gebker R, Neuss M, Fleck E, et al. Comparison of dobutamine stress magnetic resonance, adenosine stress magnetic resonance, and adenosine stress magnetic resonance perfusion. Circulation 2004;110:835-42.
10. Fung A, Gallagher K, Buda A. The physiologic basis of dobutamine as compared with dipyridamole stress inter-ventions in the assessment of critical coronary stenosis. Circulation 1987;76:943-51.
11. Elhendy A, Bax JJ, Poldermans D. Dobutamine stress myocardial perfusion imaging in coronary artery disease. J Nucl Med 2002;43:1634-46.
12. Leong-Poi H, Rim S-J, Le DE, Fisher NG, Wei K, Kaul S. Perfusion versus function: the ischemic cascade in demand ischemia: implications of single-vessel versus multivessel stenosis. Circulation 2002;105:987-92.
13. Pijls NH, De Bruyne B, Peels K, Van Der Voort PH, Bonnier HJ, Bartunek J, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med 1996;334:1703-8.
14. Boden WE, O'Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007;356:1503-16.
15. Shaw LJ, Berman DS, Maron DJ, Mancini GBJ, Hayes SW, Hartigan PM, et al. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation 2008;117: 1283-91.
16. Tonino PAL, De Bruyne B, Pijls NHJ, Siebert U, Ikeno F, van't Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary inter-vention. N Engl J Med 2009;360:213-24.
17. Pijls NHJ, Fearon WF, Tonino PAL, Siebert U, Ikeno F, Bornschein B, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary inter-vention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol 2010;56:177-84.
18. Bech GJW, De Bruyne B, Pijls NHJ, de Muinck ED, Hoorntje JCA, Escaned J, et al. Fractional flow reserve to determine the appropriateness of angioplasty in moder-ate coronary stenosis: a randomized trial. Circulation 2001;103:2928-34.
19. Pijls NHJ, van Schaardenburgh P, Manoharan G, Boersma E, Bech J-W, van't Veer M, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. J Am Coll Cardiol 2007; 49:2105-11.
20. Hachamovitch R, Hayes S, Friedman JD, Cohen I, Shaw LJ, Germano G, et al. Determinants of risk and its temporal variation in patients with normal stress myo-cardial perfusion scans: What is the warranty period of a normal scan? J Am Coll Cardiol 2003;41:1329-40.
21. Gould KL, Lipscomb K. Effects of coronary stenoses on coronary flow reserve and resistance. Am J Cardiol 1974;34:48-55.
22. Tonino PAL, Fearon WF, De Bruyne B, Oldroyd KG, Leesar MA, Ver Lee PN, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 2010;55: 2816-21.
23. Feldman RL, Nichols WW, Pepine CJ, Conetta DA, Conti CR. The coronary hemodynamics of left main and branch coronary stenoses. The effects of reduction in stenosis diameter, stenosis length, and number of stenoses. J Thorac Cardiovasc Surg 1979;77:377-88.
24. Tayebjee MH, Lip GYH, MacFadyen RJ. Collateralization and the response to obstruction of epicardial coronary arteries. QJM 2004;97:259-72.
25. van Werkhoven JM, Schuijf JD, Gaemperli O, Jukema JW, Boersma E, Wijns W, et al. Prognostic value of multislice computed tomography and gated single-photon emission computed tomography in patients with suspected cor-onary artery disease. J Am Coll Cardiol 2009;53:623-32.
26. Naghavi M, Falk E, Hecht HS, Jamieson MJ, Kaul S, Berman D, et al. From vulnerable plaque to vulnerable patient\Part III: executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) task force report. Am J Cardiol 2006;98:2H-15H.
27. Fox KAA, McLean S. Nice guidance on the investigation of chest pain. Heart 2010;96:903-6.
28. Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, et al. Diagnostic performance of 64-multi-detector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of In-dividuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 2008;52:1724-32.
29. Underwood SR, Anagnostopoulos C, Cerqueira M, Ell PJ, Flint EJ, Harbinson M, et al. Myocardial perfusion scintigraphy: the evidence. Eur J Nucl Med Mol Imaging 2004;31:261-91.
30. Melikian N, De Bondt P, Tonino P, De Winter O, Wyffels E, Bartunek J, et al. Fractional flow reserve and myocardial perfusion imaging in patients with angio-graphic multivessel coronary artery disease. J Am Coll Cardiol Intv 2010;3:307-14.
31. Berman DS, Kang X, Slomka PJ, Gerlach J, de Yang L, Hayes SW, et al. Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease. J Nucl Cardiol 2007;14:521-8.
32. Smanio P, Watson D, Segalla D, Vinson E, Smith W, Beller G. Value of gating of technetium-99m sestamibi single-photon emission computed tomographic imaging. J Am Coll Cardiol 1997;30:1687-92.
33. Dondi M, Fagioli G, Salgarello M, Zoboli S, Nanni C, Cidda C. Myocardial SPECT: what do we gain from attenuation correction (and when)? Q J Nucl Med Mol Imaging 2004;48:181-7
34. Berman DS, Kang X, Nishina H, Slomka PJ, Shaw LJ, Hayes SW, et al. Diagnostic accuracy of gated Tc-99m sestamibi stress myocardial perfusion SPECT with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patients. J Nucl Cardiol 2006;13:191-201.
35. Iskander S, Iskandrian AE. Risk assessment using single-photon emission computed tomographic technetium-99m sestamibi imaging. J Am Coll Cardiol 1998;32:57-62.
36. Bax JJ, Wijns W, Cornel JH, Visser FC, Boersma E, Fioretti PM. Accuracy of currently available techniques for prediction of functional recovery after revascularization in patients with left ventricular dysfunction due to chronic coronary artery disease: comparison of pooled data. J Am Coll Cardiol 1997;30:1451-60.
37. Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 2003; 361:374-9.
38. Ioannidis JPA, Trikalinos TA, Danias PG. Electrocardiogram-gated single-photonemission computed tomography ver-sus cardiacmagnetic resonance imaging for the assess-mentof left ventricular volumes and ejection fraction: A meta-analysis. J Am Coll Cardiol 2002;39:2059-68.
39. Fox K, Garcia MAA, Ardissino D, Buszman P, Camici PG, Crea F, et al. Guidelines on the management of stable angina pectoris: executive summary. Eur Heart J 2006;27:1341-81.
40. Antman EM, Smith SC, Alpert JS, Gregoratos G, Anderson JL, Hiratzka LF, et al., with Task Force Members. ACC/AHA/ASNC Guidelines for the Clinical Use of Cardiac Radionuclide Imaging\executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging). J Am Coll Cardiol 2003;42:1318-33.
41. Nandalur KR, Dwamena BA, Choudhri AF, Nandalur SR, Reddy P, Carlos RC. Diagnostic performance of positron emission tomography in the detection of coronary artery disease: a meta-analysis. Acad Radiol 2008;15:444-51.
42. Lertsburapa K, Ahlberg AW, Bateman TM, Katten D, Volker L, Cullom SJ, et al. Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease. J Nucl Cardiol 2008;15:745-53.
43. Yoshinaga K, Chow BJW, Williams K, Chen L, deKemp RA, Garrard L, et al. What is the prognostic value of myocardial perfusion imaging using rubidium-82 posi-tron emission tomography? J Am Coll Cardiol 2006; 48:1029-39.
44. Gerber BL, Ordoubadi FF, Wijns W, Vanoverschelde J-LJ, Knuuti MJ, Janier M, et al. Positron emission tomography using18F-fluoro-deoxyglucose and euglycaemic hyperin-sulinaemic glucose clamp: optimal criteria for the prediction of recovery of post-ischaemic left ventricular dysfunction. Results from the European Community concerted action multicenter study on use of18F-fluoro-deoxyglucose positron emission tomography for the detection of myocardial viability. Eur Heart J 2001;22: 1691-701.
45. Bateman TM, Heller GV, McGhie AI, Friedman JD, Case JA, Bryngelson JR, et al. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT. J Nucl Cardiol 2006;13:24-33.
46. Camici PG, Rimoldi OE. The clinical value of myocardial blood flow measurement. J Nucl Med 2009;50:1076-87.
47. Beleslin BD, Ostojic M, Djordjevic-Dikic A, Babic R, Nedeljkovic M, Stankovic G, et al. Integrated evaluation of relation between coronary lesion features and stress echocardiography results: the importance of coronary lesion morphology. J Am Coll Cardiol 1999;33:717-26.
48. Marwick TH, Case C, Sawada S, Rimmerman C, Brenneman P, Kovacs R, et al. Prediction of mortality using dobutamine echocardiography. J Am Coll Cardiol 2001;37:754-60.
49. McCully RB, Roger VL, Mahoney DW, Karon BL, Oh JK, Miller FA, et al. Outcome after normal exercise echocar-diography and predictors of subsequent cardiac events: follow-up of 1,325 patients. J Am Coll Cardiol 1998; 31:144-9.
50. Chung G, Krishnamani R, Senior R Prognostic value of normal stress echocardiogram in patients with suspected coronary artery disease\a British general hospital experience. Int J Cardiol 2004;94:181-6.
51. Sicari R, Nihoyannopoulos P, Evangelista A, Kasprzak J, Lancellotti P, Poldermans D, et al. Stress Echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur J Echocardiogr 2008;9:415-37.
52. Marwick TH. Techniques for comprehensive two dimen-sional echocardiographic assessment of left ventricular systolic function. Heart 2003;89:2iii-8.
53. Boudoulas H, Ruff PD, Fulkerson PK, Lewis RP. Relationship of angiographic and echographic dimen-sions in chronic left ventricular dilatation. Am Heart J 1983;106:356-62.
54. Schinkel AFL, Bax JJ, Geleijnse ML, Boersma E, Elhendy A, Roelandt JRTC, et al. Noninvasive evaluation of ischaemic heart disease: myocardial perfusion imaging or stress echocardiography? Eur Heart J 2003;24:789-800.
55. Hamon M, Fau G, Nee G, Ehtisham J, Morello R, Hamon M. Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detec-tion of coronary artery disease. J Cardiovasc Magn Reson 2010;12:29.
56. Gerber BL, Raman SV, Nayak K, Epstein FH, Ferreira P, Axel L, et al. Myocardial first-pass perfusion cardiovas-cular magnetic resonance: history, theory, and current state of the art. J Cardiovasc Magn Reson 2008;10:18.
57. Lerakis S, McLean D, Anadiotis A, Janik M, Oshinski J, Alexopoulos N, et al. Prognostic value of adenosine stress cardiovascular magnetic resonance in patients with low-risk chest pain. J Cardiovasc Magn Reson 2009;11:37.
58. Ingkanisorn WP, Kwong RY, Bohme NS, Geller NL, Rhoads KL, Dyke CK, et al. Prognosis of negative adenosine stress magnetic resonance in patients present-ing to an emergency department with chest pain. J Am Coll Cardiol 2006;47:1427-32.
59. Pilz G, Jeske A, Klos M, Ali E, Hoefling B, Scheck R, et al. Prognostic value of normal adenosine-stress cardiac magnetic resonance imaging. Am J Cardiol 2008;101: 1408-12.
60. Jahnke C, Nagel E, Gebker R, Kokocinski T, Kelle S, Manka R, et al. Prognostic value of cardiac magnetic resonance stress tests. adenosine stress perfusion and dobutamine stress wall motion imaging. Circulation 2007;115:1769-76.
61. Kim RJ, Wu E, Rafael A, Chen E-L, Parker MA, Simonetti O, et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 2000;343:1445-53.
62. Natale L, Meduri A, Caltavuturo C, Palladino F, Marano P. MRI assessment ofventricular function. Rays 2001;26:35-44.
63. Schwitter J, Wacker CM, van Rossum AC, Lombardi M, Al-Saadi N, Ahlstrom H, et al. MR-IMPACT: comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicentre, multivendor, randomized trial. Eur Heart J 2008;29:480-9.
64. Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 2003;361: 374-9.
65. Klein C, Nekolla SG, Bengel FM, Momose M, Sammer A, Haas F, et al. Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: compar-ison with positron emission tomography. Circulation 2002;105:162-7.
66. Bonow RO. Identification of viable myocardium. Circulation 1996;94:2674-80.
67. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990;15:827-32.
68. Rumberger JA, Brundage BH, Rader DJ, Kondos G Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asympto-matic persons. Mayo Clin Proc 1999;74:243-52.
69. Shaw LJ, Raggi P, Schisterman E, Berman DS, Callister TQ. Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality. Radiology 2003;228:826-33.
70. Bellasi A, Lacey C, Taylor AJ, Raggi P, Wilson PWF, Budoff MJ, et al. Comparison of prognostic usefulness of coronary artery calcium in men versus women (results from a meta-and pooled analysis estimating all-cause mortality and coronary heart disease death or myocardial infarction). Am J Cardiol 2007;100:409-14.
71. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 2008;358:1336-45.
72. Sarwar A, Shaw LJ, Shapiro MD, Blankstein R, Hoffmann U, Hoffman U, et al. Diagnostic and prognostic value of absence of coronary artery calcification. JACC Cardiovasc Imaging 2009;2:675-88.
73. Rosen BD, Fernandes V, McClelland RL, Carr JJ, Detrano R, Bluemke DA, et al. Relationship between baseline coronary calcium score and demonstration of coronary artery stenoses during follow-Up: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol Img 2009; 2:1175-83.
74. Georgiou D, Budoff MJ, Kaufer E, Kennedy JM, Lu B, Brundage BH. Screening patients with chest pain in the emergency department using electron beam tomography: a follow-up study. J Am Coll Cardiol 2001;38:105-10.
75. Moe SM, O'Neill KD, Duan D, Ahmed S, Chen NX, Leapman SB, et al. Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int 2002;61:638-47
76. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000;342:1478-83.
77. Raggi P, Boulay A, Chasan-Taber S, Amin N, Dillon M, Burke SK, et al. Cardiac calcification in adult hemodia-lysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 2002;39: 695-701.
78. Elkeles RS, Godsland IF, Feher MD, Rubens MB, Roughton M, Nugara F, et al. Coronary calcium measurement improves prediction of cardiovascular events in asympto-matic patients with type 2 diabetes: the PREDICT study. Eur Heart J 2008;29:2244-51.
79. Raggi P, Shaw LJ, Berman DS, Callister TQ. Prognostic value of coronary artery calcium screening in subjects with and without diabetes. J Am Coll Cardiol 2004; 43:1663-9.
80. Anand DV, Lim E, Hopkins D, Corder R, Shaw LJ, Sharp P, et al. Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocar-dial perfusion scintigraphy. Eur Heart J 2006;27:713-21.
81. Sarwar A, Shaw LJ, Shapiro MD, Blankstein R, Hoffmann U, Hoffman U, et al. Diagnostic and prognostic value of absence of coronary artery calcification. JACC Cardiovasc Imaging 2009;2:675-88.
82. Berman DS, Wong ND, Gransar H, Miranda-Peats R, Dahlbeck J, Hayes SW, et al. Relationship between stress-induced myocardial ischemia and atherosclerosis mea-sured by coronary calcium tomography. J Am Coll Cardiol 2004;44:923-30.
83. Schenker MP, Dorbala S, Hong ECT, Rybicki FJ, Hachamovitch R, Kwong RY, et al. Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: a combined positron emission tomography/computed tomography study. Circulation 2008;117: 1693-700.
84. Meijboom WB, Meijs MFL, Schuijf JD, Cramer MJ, Mollet NR, van Mieghem CAG, et al. Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study. J Am Coll Cardiol 2008;52:2135-44.
85. Miller JM, Rochitte CE, Dewey M, Arbab-Zadeh A, Niinuma H, Gottlieb I, et al. Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med 2008;359:2324-36.
86. Mowatt G, Cook JA, Hillis GS, Walker S, Fraser C, Jia X, et al. 64-Slice computed tomography angiography in the diag-nosis and assessment of coronary artery disease: systematic review and meta-analysis. Heart 2008;94:1386-93.
87. Stein PD, Yaekoub AY, Matta F, Sostman HD. 64-slice CT for diagnosis of coronary artery disease: a systematic review. Am J Med 2008;121:715-25.
88. Sun Z, Lin C, Davidson R, Dong C, Liao Y. Diagnostic value of 64-slice CT angiography in coronary artery disease: a systematic review. Eur J Radiol 2008;67:78-84.
89. Dodd JD, Rieber J, Pomerantsev E, Chaithiraphan V, Achenbach S, Moreiras JM, et al. Quantification of nonculprit coronary lesions: comparison of cardiac 64-MDCT and invasive coronary angiography. AJR Am J Roentgenol 2008;191:432-8.
90. Sheth T, Dodd JD, Hoffmann U, Abbara S, Finn A, Gold HK, et al. Coronary stent assessability by 64 slice multi-detector computed tomography. Catheter Cardiovasc Interv 2007;69:933-8.
91. Springer I, Dewey M. Comparison of multislice com-puted tomography with intravascular ultrasound for detection and characterization of coronary artery pla-ques: a systematic review. Eur J Radiol 2009; 71: 275-82.
92. Burgstahler C, Reimann A, Beck T, Kuettner A, Baumann D, Heuschmid M, et al. Influence of a lipid-lowering therapy on calcified and noncalcified coronary plaques monitored by multislice detector computed tomography: results of the New Age II Pilot Study. Invest Radiol 2007;42:189-95.
93. Ferencik M. Assessment of coronary plaque burden by computed tomography: getting closer\step by step. Heart 2010;96:575-6.
94. Motoyama S, Kondo T, Sarai M, Sugiura A, Harigaya H, Sato T, et al. Multislice computed tomographic character-istics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol 2007;50:319-26.
95. Hulten EA, Carbonaro S, Petrillo SP, Mitchell JD, Villines TC. Prognostic value of cardiac computed tomography angiography: a systematic review and meta-analysis. J Am Coll Cardiol 2011;57:1237-47.
96. Danciu SC, Herrera CJ, Stecy PJ, Carell E, Saltiel F, Hines JL. Usefulness of multislice computed tomographic coronary angiography to identify patients with abnormal myocardial perfusion stress in whom diagnostic cathe-terization may be safely avoided. Am J Cardiol 2007; 100:1605-8.
97. Hoffmann U, Bamberg F, Chae CU, Nichols JH, Rogers IS, Seneviratne SK, et al. Coronary computed tomogra-phy angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) Trial. J Am Coll Cardiol 2009;53:1642-50.
98. Hollander JE, Chang AM, Shofer FS, McCusker CM, Baxt WG, Litt HI. Coronary computed tomographic angiography for rapid discharge of low-risk patients with potential acute coronary syndromes. Ann Emerg Med 2009;53:295-304.
99. Schuijf JD, Bax JJ, Shaw LJ, de Roos A, Lamb HJ, van der Wall EE, et al. Meta-analysis of comparative diagnostic performance of magnetic resonance imaging and multi-slice computed tomography for noninvasive coronary angiography. Am Heart J 2006;151:404-11.
100. Bluemke DA, Achenbach S, Budoff M, Gerber TC, Gersh B, Hillis LD, et al. Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific state-ment from the American Heart Association Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention, and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young. Circulation 2008;118:586-606.
101. Mettler FA, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: a catalog. Radiology 2008;248:254-63
102. Einstein AJ, Moser KW, Thompson RC, Cerqueira MD, Henzlova MJ. Radiation dose to patients from cardiac diagnostic imaging. Circulation 2007;116:1290-305.
103. Gerber TC, Carr JJ, Arai AE, Dixon RL, Ferrari VA, Gomes AS, et al. Ionizing radiation in cardiac imaging: a science advisory from the American Heart Association Committee on Cardiac Imaging of the Council on Clinical Cardiology and Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention. Circulation 2009;119: 1056-65.
104. Hunold P, Vogt FM, Schmermund A, Debatin JF, Kerkhoff G, Budde T, et al. Radiation exposure during cardiac CT: effective doses at multi-detector row CT and electron-beam CT. Radiology 2003;226:145-52.
105. Alkadhi H, Stolzmann P, Scheffel H, Desbiolles L, Baumüller S, Plass A, et al. Radiation dose of cardiac dual-source CT: the effect of tailoring the protocol to patient-specific parameters. Eur J Radiol 2008;68:385-91.
106. Hausleiter J, Meyer T, Hermann F, Hadamitzky M, Krebs M, Gerber TC, et al. Estimated radiation dose associated with cardiac CT angiography. JAMA 2009;301:500-7
107. Carr CL, Lindner JR. Myocardial perfusion imaging with contrast echocardiography. Curr Cardiol Rep 2008;10: 233-9.
108. Dijkmans PA, Senior R, Becher H, Porter TR, Wei K, Visser CA, et al. Myocardial contrast echocardiography evolving as a clinically feasible technique for accurate, rapid, and safe assessment of myocardial perfusion: the evidence so far. J Am Coll Cardiol 2006;48:2168-77.
109. Salerno M, Beller GA. Noninvasive assessment of myo-cardial perfusion. Circ Cardiovasc Imaging 2009;2: 412-24.
110. Bhan A, Kapetanakis S, Rana BS, Ho E, Wilson K, Pearson P, et al. Real-time three-dimensional myocardial contrast echocardiography: is it clinically feasible? Eur J Echocardiogr 2008;9:761-5.
111. Blankstein R, Shturman LD, Rogers IS, Rocha-Filho JA, Okada DR, Sarwar A, et al. Adenosine-induced stress myocardial perfusion imaging using dual-source cardiac computed tomography. J Am Coll Cardiol 2009;54:1072-84.
112. George RT, Arbab-Zadeh A, Miller JM, Kitagawa K, Chang H-J, Bluemke DA, et al. Adenosine Stress 64-and 256-row detector computed tomography angiography and perfusion imaging: clinical perspective. Circ Cardio-vasc Imaging 2009;2:174-82.
113. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 2003;108:1664-72.
114. Kramer CM, Narula J. Atherosclerotic plaque imaging: the last frontier for cardiac magnetic resonance. J Am Coll Cardiol Img 2009;2:916-18.
115. Tahara N, Kai H, Ishibashi M, Nakaura H, Kaida H, Baba K, et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006;48:1825-31.
116. Garcia-Garcia HM, Costa MA, Serruys PW. Imaging of coronary atherosclerosis: intravascular ultrasound. Eur Heart J 2010;31:2456-69.
117. Stamper D, Weissman NJ, Brezinski M. Plaque character-ization with optical coherence tomography. J Am Coll Cardiol 2006;47(Suppl. 8):C69-79.