Neuropsychiatric symptoms in older people with and without cognitive impairment

Journal of Alzheimer's Disease

Volumn 31, Issue 2, 2012, Pages 411-420

  Brodaty, Henry ^a   Heffernan, Megan ^a   Draper, Brian ^a   Reppermund, Simone ^a   Kochan, Nicole A ^a,b   Slavin, Melissa J ^a   Trollor, Julian N ^a   Sachdev, Perminder S ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Cognitive deficits; dementia; mild cognitive impairment; neuropsychiatric symptoms

Indexed keywords

AGED; AGITATION; ANXIETY; APATHY; APPETITE DISORDER; ARTICLE; ATTENTION; BEHAVIOR DISORDER; COGNITION; CROSS-SECTIONAL STUDY; DELUSION; DEMENTIA; DEPRESSION; DEPTH PERCEPTION; DISEASE ASSOCIATION; DISEASE COURSE; EXECUTIVE FUNCTION; FEMALE; FOLLOW UP; HALLUCINATION; HUMAN; IRRITABILITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MENTAL DISEASE; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; PREVALENCE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SLEEP DISORDER;

EID: 84865597194     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120169     Document Type: Article

References (43)

1. Lyketsos CG, SteinbergM, Tschanz JT, Norton MC, Steffens DC, Breitner JC (2000) Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging. Am J Psychiatry 157, 708-714. (Pubitemid 30249648)
2. Apostolova LG, Cummings JL (2008) Neuropsychiatric manifestations in mild cognitive impairment: A systematic review of the literature. Dement Geriatr Cogn Disord 25, 115-126. (Pubitemid 351196123)
3. Monastero R, Mangialasche F, Camarda C, Ercolani S, Camarda R (2009) A systematic review of neuropsychiatric symptoms in mild cognitive impairment. J Alzheimers Dis 18, 11-30.
4. Di Iulio F, Palmer K, Blundo C, Casini AR, Gianni W, Caltagirone C, SpallettaG(2010) Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes. Int Psychogeriatr 22, 629-640.
5. Geda YE, Roberts RO, Knopman DS, Petersen RC, Christianson TJH, Pankratz VS, Smith GE, Boeve BF, Ivnik RJ, Tangalos EG, Rocca WA (2008) Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: Population-based study. Arch Gen Psychiatry 65, 1193-1198.
6. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S (2002) Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment. JAMA-J Am Med Assoc 288, 1475-1483.
7. Mitchell AJ, Shiri-Feshki M (2009) Rate of progression of mild cognitive impairment to dementia-meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 119, 252-265.
8. Caracciolo B, B̈ackman L, Monastero R, Winblad B, Fratiglioni L (2011) The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: A cohort study of a community dwelling elderly population. J Neurol Neurosurg Psychiatry 82, 788-793.
9. Palmer K, Berger AK, Monastero R, Winblad B, Backman L, Fratiglioni L (2007) Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology 68, 1596-1602. (Pubitemid 46717984)
10. Teng E, Lu PH, Cummings JL (2007) Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease. Dement Geriatr Cogn Disord 24, 253-259. (Pubitemid 47482071)
11. Chan WC, LamLCW, TamCWC,LuiVWC,LeungGTY, Lee ATC, Chan SSM, Fung AWT, Chiu HFK, Chan WM (2011) Neuropsychiatric symptoms are associated with increased risks of progression to dementia: A 2-year prospective study of 321 Chinese older persons with mild cognitive impairment. Age Ageing 40, 30-35.
12. Gabryelewicz T, Styczynska M, Luczywek E, Barczak A, Pfeffer A, Androsiuk W, Chodakowska-Zebrowska M, Wasiak B, Peplonska B, Barcikowska M (2007) The rate of conversion of mild cognitive impairment to dementia: Predictive role of depression. Int J Geriatr Psych 22, 563-567. (Pubitemid 46951755)
13. Potvin O, Forget H, Grenier S, Pŕeville M, Hudon C (2011) Anxiety, depression, and 1-year incident cognitive impairment in community-dwelling older adults. J Am Geriatr Soc 59, 1421-1428.
14. Becker JT, Chang Y-F, Lopez OL, Dew MA, Sweet RA, Barnes D, Yaffe K, Young J, Kuller L, Reynolds CFI (2009) Depressed mood is not a risk factor for incident dementia in a community-based cohort. Am J Geriatr Psychiat 17, 653-663.
15. Gallagher D, Coen R, Kilroy D, Belinski K, Bruce I, Coakley D, Walsh B, Cunningham C, Lawlor BA (2011) Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. Int J Geriatr Psych 26, 166-172.
16. Palmer K, Di Iulio F, Varsi AE, Gianni W, Sancesario G, Caltagirone C, SpallettaG(2010) Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: The role of depression and apathy. J Alzheimers Dis 20, 175-183.
17. Vicini Chilovi B, Conti M, Zanetti M, Mazz̀u I, Rozzini L, Padovani A (2009) Differential impact of apathy and depression in the development of dementia in mild cognitive impairment patients. Dement Geriatr Cogn Disord 27, 390-398.
18. Robert PH, Berr C, Volteau M, Bertogliati-Fileau C, Benoit M, Guerin O, Sarazin M, Legrain S, Dubois B, PŕeAL Study Group (2008) Importance of lack of interest in patients with mild cognitive impairment. Am J Geriatr Psychiat 16, 770-776.
19. Sinoff G, Werner P (2003) Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. Int J Geriatr Psych 18, 951-959. (Pubitemid 37294857)
20. Devier DJ, Pelton GH, Tabert MH, Liu X, Cuasay K, Eisenstadt R, Marder K, Stern Y, Devanand DP (2009) The impact of anxiety on conversion from mild cognitive impairment to Alzheimer's disease. Int J Geriatr Psych 24, 1335-1342.
21. Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakos JM, Lyketsos CG (2011) Neuropsychiatric symptoms in MCI subtypes: The importance of executive dysfunction. Int J Geriatr Psych 26, 364-372.
22. Sachdev P, Brodaty H, Reppermund S, Kochan NA, Trollor J, Draper B, Slavin MJ, Crawford J, Kang K, Broe GA, Mather KA, Lux O (2010) The Sydney Memory and Ageing Study (MAS): Methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years. Int Psychogeriatr 22, 1248-1254.
23. Anderson TM, Sachdev PS, Brodaty H, Trollor JN, Andrews G (2007) Effects of sociodemographic and health variables on Mini-Mental State Exam scores in older Australians. Am J Geriatr Psychiat 15, 467-476.
24. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
25. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Kokmen E, Tangelos EG (1997) Aging, Memory, and Mild Cognitive Impairment. Int Psychogeriatr 9, 65-69. (Pubitemid 28045341)
26. PetersenRC(2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256, 183-194. (Pubitemid 39222988)
27. Kochan NA, Slavin MJ, Brodaty H, Crawford JD, Trollor JN, Draper B, Sachdev PS (2010) Effect of different impairment criteria on prevalence of "objective" mild cognitive impairment in a community sample. Am J Geriatr Psychiat 18, 711-722.
28. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314. (Pubitemid 24382728)
29. Feng L, Yap PLK, Lee TS, Ng TP (2009) Neuropsychiatric symptoms in mild cognitive impairment: A population-based study. Asia-Pacific Psychiatry 1, 23-27.
30. Cummings JL (1997) The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology 48, S10-S16. (Pubitemid 27232698)
31. Wechsler D (1997)Wechsler Adult Intelligence Scale-III, The Psychological Corporation, San Antonio.
32. Strauss E, Sherman EMS, Spreen O (2006) A Compendium of Neuropsychological Tests: Administration, Norms and Commentary, Oxford University Press, New York.
33. Tombaugh TN (2004) Trail Making Test A and B: Normative data stratified by age and education. Arch Clin Neuropsych 19, 203-214. (Pubitemid 38316871)
34. Wechsler D (1997) Wechsler Memory Scale. Third edition manual, The Psychological Corporation, San Antonio.
35. Grundman M, Petersen RC, Ferris SH, Thomas RG, Aisen PS, Bennett DA, Foster NL, Jack CR Jr, Galasko DR, Doody R, Kaye J, Sano M, Mohs R, Gauthier S, Kim HT, Jin S, Schultz AN, Schafer K, Mulnard R, van Dyck CH, Mintzer J, Zamrini EY, Cahn-Weiner D, Thal LJ (2004) Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 61, 59-66. (Pubitemid 38067415)
36. Ivnik RJ, Malec JF, Smith GE, Tangalos EG, Petersen RC, Kokmen E, Kurland LT (1992) Mayo's older Americans normative studies: Updated AVLT norms for ages 56 to 97. Clin Neuropsychol 6, 83-104.
37. Ivnik RJ, Malec JF, Smith GE, Tangalos EG, Petersen RC, Kokmen E, Kurland LT (1992) Mayo's older Americans normative studies: WAIS-R norms for ages 56 to 97. Clin Neuropsychol 6, 1-30.
38. Benton AL, Sivan AB, Spreen O (1996) Der Benton Test Manual, Huber, Bern.
39. Lechevallier Michel N, Fabrigoule C, Lafont S, Letenneur L, Dartigues J (2004) Normes por le MMSE, le Test de Retention Visuelle de Benton, le Set Test d'Isaacs (15s. et 60s), le soustest des Codes de la WAIS et le Test Barrage de Zazzo, en function de l'age, du sexe et du niveau d'etudes, chez des sujets ages de 70 ans et plus: Donnees de la chorte PAQUID. Rev Neurol (Paris) 160, 1059-1070. (Pubitemid 39564062)
40. Kaplan E (2001) The Boston Naming Test, Lippincott Williams Wilkins, Philadelphia.
41. Fastenau PS, Denburg NL, Mauer BA (1998) Parallel short forms for the Boston Naming Test: Psychometric properties and norms for older adults. J Clin Exp Neuropsychol 20, 828-834. (Pubitemid 29284457)
42. Tombaugh TN, Kozak J, Rees L (1999) Normative Data stratified by age and education for two measures of verbal fluency: FAS and Animal Naming. Arch Clin Neuropsych 14, 167-177. (Pubitemid 29108542)
43. Wechsler D (1981) WAIS-R Manual, The Psychological Corporation, New York.