Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes

International Psychogeriatrics

Volumn 22, Issue 4, 2010, Pages 629-640

  Di Iulio, Fulvia ^a   Palmer, Katie ^a   Blundo, Carlo ^b   Casini, Anna Rosa ^c   Gianni, Walter ^d   Caltagirone, Carlo ^a,e   Spalletta, Gianfranco ^a,e  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

^d INRCA   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Alzheimer's disease; Apathy; Dementia; Depression; Psychiatric disorders

Indexed keywords

AGED; AGITATION; ALZHEIMER DISEASE; AMNESIA; ANXIETY; APATHY; APPETITE DISORDER; ARTICLE; CAREGIVER BURDEN; COGNITION; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; IRRITABILITY; ITALY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MENTAL HEALTH CENTER; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROPSYCHIATRIC INVENTORY; NEUROPSYCHIATRY; SCORING SYSTEM; STRUCTURED INTERVIEW; SYMPTOM;

AGED; ALZHEIMER DISEASE; BRAIN; COGNITION DISORDERS; FEMALE; HUMANS; MALE; MENTAL DISORDERS; NEUROPSYCHOLOGICAL TESTS; SEVERITY OF ILLNESS INDEX;

EID: 77952431114     PISSN: 10416102     EISSN: 1741203X     Source Type: Journal    
DOI: 10.1017/S1041610210000281     Document Type: Article

References (38)

1. Aalten, P., van Valen, E., de Vugt, M., Lousberg, R., Jolles, J. and Verhey, F. R. (2006). Awareness and behavioral problems in dementia patients: a prospective study. International Psychogeriatrics, 18, 3-17.
2. Aalten, P. et al. (2008). Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II. Dementia and Geriatric Cognitive Disorders, 25, 1-8.
3. Apostolova, L. G. and Cummings, J. L. (2008). Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature. Dementia and Geriatric Cognitive Disorders, 25, 115-126.
4. Apostolova, L. G. et al. (2007). Structural correlates of apathy in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 24, 91-97.
5. Asada, T., Kinoshita, T. and Kakuma, T. (2000). Analysis of behavioral disturbances among community-dwelling elderly with Alzheimer disease. Alzheimer Disease and Associated Disorders, 14, 160-167.
6. Black, W. and Almeida, O. P. (2004). A systematic review of the association between the Behavioral and Psychological Symptoms of Dementia and burden of care. International Psychogeriatrics, 16, 295-315.
7. Carlesimo, G. A., Caltagirone, C. and Gainotti, G. (1996). The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment: the Group for the Standardization of the Mental Deterioration Battery, European Neurology, 36, 378-384.
8. Cummings, J. L. (1997). The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology, 48, S10-16.
9. Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
10. Geda, Y. E. et al. (2008): Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study. Archives of General Psychiatry, 65, 1193-1198.
11. Jeste, D. V. and Finkel, F. I. (2000). Psychosis in Alzheimer's disease and related dementias. American Journal of Geriatric Psychiatry, 8, 29-34.
12. Jeste, D. V., Wragg, R. E., Salmon, D. P., Harris, M. J. and Thal, L. J. (1992). Cognitive deficits of patients with Alzheimer's disease with and without delusion. American Journal of Psychiatry, 149, 184-189.
13. Katz, S. (1983). Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. Journal of the American Geriatric Society, 31:721-727.
14. Lawton, M. P. and Brody, E. M. (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 9, 179-186.
15. Magni, E., Binetti, G., Bianchetti, A., Rozzini, R. and Trabucchi, M. (1996). Mini-mental state examination: a normative study in an Italian elderly population. European Journal of Neurology, 3, 1-5.
16. Marshall, G. A., Fairbanks, L. A., Tekin, S., Vinters, H. V. and Cummings, J. L. (2006). Neuropathologic correlates of apathy in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 21, 144-147.
17. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Service Task Force on Alzheimer's Disease. Neurology, 34, 939-944.
18. Monastero, R., Mangialasche, F., Camarda, C., Ercolani, S. and Camarda, R. (2010). A systematic review of neuropsychiatric symptoms in Mild Cognitive Impairment. Journal of Alzheimer's Disease, epublished ahead of print.
19. Morin, C. M., LeBlanc, M., Daley, M., Gregoire, J. P. and Mérette, C. (2006). Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviours. Sleep Medicine, 7, 123-130.
20. Olin, J. et al. (2002). Provisional diagnostic criteria for depression in Alzheimer's disease. American Journal of Geriatric Psychiatry, 10, 129-141.
21. Orfei, M. D. et al. (2010). Anosognosia in Mild Cognitive Impairment and mild Alzheimer's disease: frequency and neuropsychological correlates. American Journal of Geriatric Psychiatry, in press.
22. Palmer, K., Berger, A. K., Monastero, R., Winblad, B., Bäckman, L. and Fratiglioni, L. (2007). Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology, 68, 1596-1602. (Pubitemid 46717984)
23. Palmer, K., Bäckman, L., Winblad, B. and Fratiglioni, L. (2008). Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop Alzheimer's disease. International Psychogeriatrics, 20, 252-258. doi:10.1017/S1041610207006564. (Pubitemid 351230233)
24. Palmer, K. et al. (2010). Neuropsychiatric predictors of progression from amnestic-Mild Cognitive Impairment to Alzheimer's disease: the role of depression and apathy. Journal of Alzheimer's Disease, in press.
25. Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L. and DeKosky, S. T. (2001). Practice parameter. Early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1133-1142.
26. Rapp, M. et al. (2006). Increased hippocampal paques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Archives of General Psychiatry, 63, 161-167.
27. Robert, P. H. et al. (2008): Importance of lack of interest in patients with mild cognitive impairment. American Journal of Geriatric Psychiatry, 16, 770-776.
28. Simard, M., Hudon, C. and Van Reekum, R. (2009). Psychological distress and risk for dementia. Current Psychiatry Reports, 11, 41-47.
29. Spalletta, G. et al. (2004). Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease. Journal of Neurology, 251, 688-695.
30. Spalletta, G. et al. (2010). Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated Alzheimer disease patients. American Journal of Geriatric Psychiatry; in press.
31. Starkstein, S. E., Petracca, G., Chemerinski, E. and Kremer, J. (2001). Syndromic validity of apathy in Alzheimer's disease. American Journal of Psychiatry, 158, 872-877.
32. Starkstein, S. E., Jorge, R., Mizrahi, R. and Robinson, R. G. (2006). A prospective longitudinal study of apathy in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 77, 8-11.
33. Sweet, R. A. et al. (2002). Psychosis in Alzheimer disease: post-mortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology. Neurobiology of Aging, 23, 547-553.
34. Tagariello, P., Girardi, P. and Amore, M. (2009). Depression and apathy in dementia: Same syndrome or different constructs? A critical review. Archives of Gerontology and Geriatrics, 49, 246-249.
35. Thomas, P., Hazif-Thomas, C., Saccardy, F. and Vandermarq, P. (2004). Loss of motivation and frontal dysfunction: role of white matter change. Encephale, 30, 52-59.
36. Vicini Chilovi, B., Conti, M., Zanetti, M., Mazzù, I., Rozzini, L. and Padovani, A. (2009). Differential impact of apathy and depression in the development of dementia in mild cognitive impairment patients. Dementia and Geriatric Cognitive Disorders, 27, 390-398.
37. Weamer, E. A. et al. (2009). The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis. International Psychogeriatrics, 21, 78-85. doi:10.1017/ S1041610208007734.
38. Zhao, Z., Taylor, W. D., Styner, M., Steffens, D. C., Krishnan, K. R. and MacFall, J. R. (2008). Hippocampus shape analysis and late-life depression. PLoS ONE, 19; 3, e1837.