Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: Population-based study

Archives of General Psychiatry

Volumn 65, Issue 10, 2008, Pages 1193-1198

  Geda, Yonas E ^a,b,d   Roberts, Rosebud O ^b,d   Knopman, David S ^a,d   Petersen, Ronald C ^a,d   Christianson, Teresa J H ^a,d   Pankratz, Vernon S ^a,d   Smith, Glenn E ^a,d   Boeve, Bradley F ^a,d   Ivnik, Robert J ^a,d   Tangalos, Eric G ^c,d   Rocca, Walter A ^a,b,d  

^a Department of Psychiatry and Psychology ^*

^b Divisions of Epidemiology

^c Primary Care Internal Medicine

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; AGITATION; ANXIETY; APATHY; ARTICLE; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; CONSENSUS; DELUSION; DEMENTIA; DISEASE CLASSIFICATION; EDUCATIONAL STATUS; FEMALE; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DEFICIENCY; NEUROPSYCHIATRIC INVENTORY QUESTIONNAIRE SCORE; PREVALENCE; PROSPECTIVE STUDY; QUESTIONNAIRE; SCORING SYSTEM; SYMPTOM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COGNITION DISORDERS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MINNESOTA; NEUROPSYCHOLOGICAL TESTS; PROSPECTIVE STUDIES; PSYCHOMETRICS; REFERENCE VALUES;

EID: 53849148954     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.65.10.1193     Document Type: Article

References (29)

1. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303-308.
2. [published correction appears in Arch Neurol. 1999;56(6):760]
3. Grundman M, Petersen RC, Ferris SH, Thomas RG, Aisen PS, Bennett DA, Foster NL, Jack CR Jr, Galasko DR, Doody R, Kaye J, Sano M, Mohs R, Gauthier S, Kim HT, Jin S, Schultz AN, Schafer K, Mulnard R, van Dyck CH, Mintzer J, Zamrini EY, Cahn-Weiner D, Thal LJ; Alzheimer's Disease Cooperative Study. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol. 2004;61(1):59-66.
4. Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ; Alzheimer's Disease Cooperative Study Group. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352(23):2379-2388.
5. Crook T, Bartus R, Ferris S, Whitehouse P, Cohen G, Gershon S. Age-associated memory impairment: proposed diagnostic criteria and measures of clinical change: report of a National Institute of Mental Health Work Group. Dev Neuropsychol. 1986;2:261-276.
6. Reisberg B, Ferris SH, de Leon MJ, Sinaiko E, Franssen E, Kluger A, Mir P, Borenstein J, George AE, Shulman E, Steinberg G, Cohen J. Stage-specific behavioral, cognitive, and in vivo changes in community residing subjects with ageassociated memory impairment and primary degenerative dementia of the Alzheimer type. Drug Dev Res. 1988;15(2-3):101-114. doi:10.1002/ddr. 430150203.
7. Blackford R, LaRue A. Criteria for diagnosing age associated memory impairment. Dev Neuropsychol. 1989;5:295-306.
8. Flicker C, Ferris SH, Reisberg B. Mild cognitive impairment in the elderly: predictors of dementia. Neurology. 1991;41(7):1006-1009.
9. Devanand DP, Folz M, Gorlyn M, Moeller JR, Stern Y. Questionable dementia: clinical course and predictors of outcome. J Am Geriatr Soc. 1997;45(3):321-328.
10. Graham JE, Rockwood K, Beattie BL, Eastwood R, Gauthier S, Tuokko H, McDowell I. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet. 1997;349(9068):1793-1796.
11. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment: an evidence-based review: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56(9):1133-1142.
12. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004; 256(3):183-194.
13. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC. Mild cognitive impairment: beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256(3):240-246.
14. Geda YE, Smith GE, Knopman DS, Boeve BF, Tangalos EG, Ivnik RJ, Mrazek DA, Edland SD, Petersen RC. De novo genesis of neuropsychiatric symptoms in mild cognitive impairment (MCI). Int Psychogeriatr. 2004;16(1):51-60.
15. Hwang TJ, Masterman DL, Ortiz F, Fairbanks LA, Cummings JL. Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Dis Assoc Disord. 2004;18(1):17-21.
16. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the Cardiovascular Health Study. JAMA. 2002;288(12): 1475-1483.
17. Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000;157(5):708-714.
18. Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Ivnik RJ, Tangalos EG, Petersen RC, Rocca WA. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology. 2008;30(1):58-69.
19. Ivnik RJ, Malec JF, Smith GE, Tangalos EG, Petersen RC, Kokmen E, Kurland LT. Mayo's Older Americans Normative Studies: WAIS-RN or ms for Ages 56 to 97. Clin Neuropsychol. 1992;65(S1):1-30. doi:10.1080/13854049208401.
20. American Psychiatric Association. Task Force on DSM-IV. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. 4th ed. Washington, DC: American Psychiatric Association; 1994.
21. Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, Lopez OL, DeKosky ST. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000;12(2):233-239.
22. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308-2314.
23. Morris JC, Weintraub S, Chui HC, Cummings J, Decarli C, Ferris S, Foster NL, Galasko D, Graff-Radford N, Peskind ER, Beekly D, Ramos EM, Kukull WA. The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers. Alzheimer Dis Assoc Disord. 2006;20(4):210-216.
24. Last JM; International Epidemiological Association. A Dictionary of Epidemiology. 4th ed. New York, NY: Oxford University Press; 2001.
25. Little RJ. Survey nonresponse adjustments for estimates of means. Int Stat Rev. 1986;54(2):139-157. doi:10.2307/1403140.
26. Kessler RC, Little RJ, Groves RM. Advances in strategies for minimizing and adjusting for survey nonresponse. Epidemiol Rev. 1995;17(1):192-204.
27. D'Agostino RB Jr, Rubin DB. Estimating and using propensity scores with partially missing data. J Am Stat Assoc. 2000;95(451):749-759. doi:10.2307/2669455.
28. Palmer K, Berger AK, Monastero R, Winblad B, Bäckman L, Fratiglioni L. Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology. 2007;68(19):1596-1602.
29. Wilson RS, Barnes LL, Mendes de Leon CF, Aggarwal NT, Schneider JS, Bach J, Pilat J, Beckett LA, Arnold SE, Evans DA, Bennett DA. Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology. 2002;59(3):364-370.