β-D-Glucosyl Conjugates of Highly Potent Inhibitors of Blood Coagulation Factor Xa Bearing 2-Chorothiophene as a P1 Motif

ChemMedChem

Volumn 7, Issue 9, 2012, Pages 1669-1677

  Lopopolo, Gianfranco ^a   de Candia, Modesto ^a   Panza, Luigi ^b   Romano, Maria Rosaria ^a   Lograno, Marcello Diego ^a   Campagna, Francesco ^a   Altomare, Cosimo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Factor Xa; Glycosides; Inhibitors; Thrombin; Thromboembolism

Indexed keywords

1 ISOPROPYLPIPERIDINE; 3 (2 {[5 (5 CHLOROTHIOPHEN 2 YL)ISOXAZOL 3 YL]METHOXY} 3 [(1 ISOPROPYL)PIPERIDINE 4 CARBOXAMIDO]PHENOXY)PROPYL 2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSIDE; 3 (2 {[5 (5 CHLOROTHIOPHEN 2 YL)ISOXAZOL 3 YL]METHOXY} 3 [(1 ISOPROPYL)PIPERIDINE 4 CARBOXAMIDO]PHENOXY)PROPYL BETA DEXTRO GLUCOPYRANOSIDE; 5 CHLOROTHIEN 2 YL; AMIDE; BLOOD CLOTTING FACTOR 10A INHIBITOR; GLUCOSE DERIVATIVE; GLYCOSIDE; PHENYL GROUP; SERINE PROTEINASE; THIOPHENE DERIVATIVE; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; EX VIVO STUDY; HUMAN; IN VITRO STUDY; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOPLASTIN TIME;

EID: 84865595418     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200224     Document Type: Article

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