Tranexamic acid reduces blood loss in simultaneous bilateral total knee arthroplasty: A randomized control trial

European Journal of Orthopaedic Surgery and Traumatology

Volumn 22, Issue 5, 2012, Pages 381-386

  Raviraj, A ^a   Anand, Ashish ^a,b   Chakravarthy, Murali ^a   Kumarswamy, S ^a   Prabhu, Ajith ^a   Pai, Sanjay ^a  

^a Fortis Hospitals   (India)

^b St Catherine Medical Center   (United States)

Author keywords

Blood loss; Blood transfusion; Joint replacement; Total knee replacement arthroplasty; Tranexamic acid

Indexed keywords

HEMOGLOBIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; TRANEXAMIC ACID; WARFARIN;

AGED; ARTICLE; BLOOD TRANSFUSION; CONTINUOUS INFUSION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DEEP VEIN THROMBOSIS; DRUG COST; FEMALE; HEALTH CARE COST; HEMATOCRIT; HUMAN; INTERMETHOD COMPARISON; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PERIOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOTAL KNEE REPLACEMENT;

EID: 84865438227     PISSN: 16338065     EISSN: 14321068     Source Type: Journal    
DOI: 10.1007/s00590-011-0845-3     Document Type: Article

References (39)

1. Samama CM (2004) A direct antifibrinolytic agent in major orthopaedic surgery. Orthopaedic 27(6 suppl):S675-S680
2. Guay J, Haig M, Lortie L, Guertin MC, Poitras B (1994) Pre-dicting blood loss in surgery for idiopathic scoliosis. Can JAna-esth 41:775-781
3. Copley LA, Richards BS, Safavi FZ, Newton PO (1999) He-modilution as a method to reduce transfusion requirements in adolescent spine fusion surgery. Spine 24:219-222
4. Murray DJ, Forbes RB, Titone MB, Weinstein SL (1997) Transfusion management in pediatric and adolescent scoliosis surgery: efficacy of autologous blood. Spine: 22:2735
5. Hardy JF, Desroches J (1992) Natural and synthetic antifibrino-lytics in cardiac surgery. Can J Anaesth 39:353-365
6. Neilipovitz DT (2004) Tranexamic acid for major spinal surgery. Eur Spine J 13:S62-S65
7. Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B et al (2007) Anti-fibrinolytic use for minimizing perioperative allogenic blood transfusion (review). Cochrane Database Syst Rev. Issue 4
8. Vera-Llonch M (2006) Clinical and economic consequences of bleeding following major orthopaedic surgery. Thromb Res 117: 569-577
9. Cid Lozano (2005) Tranexamic acid reduces allogenic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion 45:1302-1307
10. Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, Fergusson DA, Ker K (2011) Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 3:CD001886
11. Zufferey P, Merquiol F, Laporte S, Decousus H, Mismetti P, Auboyer C et al (2006) Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 105: 1034-1046
12. Charoencholvanich K, Siriwattanasakul P (2011) Tranexamic acid reduces blood loss and blood transfusion after TKA: a pro-spective randomized controlled trial. Clin Orthop Relat Res [Epub ahead of print]
13. Liu TK, Chen SH (1998) Simultaneous bilateral total knee arthroplasty in a single procedure. Int Orthop 22:390-393
14. Brotherton SL, Roberson JR, de Andrade JR, Fleming LL (1986) Staged versus simultaneous bilateral total knee replacement. J Arthroplasty 1(4):221-228
15. MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT (2011) Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study. J Arthroplasty 26(1):24-28
16. Dhillon MS, Bali K, Prabhakar S (2011) Tranexamic acid for control of blood lossin bilateral total knee replacement in a single stage. Indian J Orthop 45(2):148-152
17. Zhang F, Gao Z, Yu J (2007) Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21(12):1302-1304
18. Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE (2007) Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 89(3):306-309
19. Camarasa MA, Ollé G, Serra-Prat M, Martín A, Sánchez M, Ricós P, Pérez A, Opisso L (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96(5): 576-582
20. Orpen NM, Little C, Walker G, Crawfurd EJ (2006) Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee 13(2):106-110
21. Zohar E, Ellis M, Ifrach N, Stern A, Sapir O, Fredman B (2004) The postoperative blood-sparing efficacy of oral versus intrave-nous tranexamic acid after total knee replacement. Anesth Analg 99(6):1679-1683 Table ofcontents
22. Kakar PN, Gupta N, Govil P, Shah V (2009) Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesth 53(6):667-671
23. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Roderick Davey J, Gandhi R, Syed KA, Muhammad Ovais HasanS, De Silva Y, Chung F (2010) Topical application oftranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 92(15):2503-2513
24. Hiippala ST, Strid LJ, Wennerstrand MI et al (1997) Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 84:839-844
25. Alvarez JC, Santiveri FX, Ramos I, Vela E, Puig L, Escoano F (2008) Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 48:519-525
26. Tzortzopoulou A, Cepeda MS, Schumann R, Carr DB (2008) Antifibrinolytic agents for reducing blood loss in scoliosis sur-gery in children. Cochrane Database Syst Rev 3:CD006883
27. Urban MK, Beckman J, Gordon M, Urqhart B, Boachie-Adjei O (2001) The efficacy of antifibrinolytics in the reduction of blood loss during complex adult reconstructive spine surgery. Spine 26:1152-1156
28. Florentino-Pineda I, Thompson GH, Poe-Kochert C, Huang RP, Haber LL, Blakemore LC (2004) The effect of amicar on peri-operative blood loss in idiopathic scoliosis: the results of a pro-spective, randomized double-blind study. Spine 29:233-238
29. Yamasaki S, Masuhara K, Fuji T (2005) Tranexamic acid reduces postoperative blood loss in cement less total hip arthroplasty. J Bone Joint Surg Am 87:766-770
30. Johansson T, Pettersson LG, Lisander B (2005) Tranexamic acid in total hip arthroplasty saves blood and money: a randomized, double-blind study in 100 patients. Acta Orthop 76:314-319
31. Camarasa MA, Ollé G, Serra-Prat M et al (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96:576-582
32. Chung LH, Chen WM, Chen CF, Chen TH, Liu CL (2011) Deep vein thrombosis after total knee arthroplasty in asian patients without prophylactic anticoagulation. Orthopedics 34(1):15
33. Wang CJ, Wang JW, Weng LH, Hsu CC, Huang CC, Yu PC (2004) Prevention of deep-vein thrombosis after total knee arthroplasty in Asian patients Comparison of low-molecular-weight heparin and indomethacin. J Bone Joint Surg Am 86-A:136-140
34. Chin PL, Amin MS, Yang KY, Yeo SJ, Lo NN (2009) Throm-boembolic prophylaxis for total knee arthroplasty in Asian patients: a randomized controlled trial. J Orthop Surg (Hong Kong) 17(1):1-5
35. Lozano M, Basora M, Peidro L, Merino I, Segur JM, Pereira A, Salazar F, Cid J, Lozano L, Mazzara R, Macule F (2008) Effectiveness and safety of tranexamic acid administration during total knee arthroplasty. Vox Sang 95(1):39-44
36. Sepah YJ, Umer M, Ahmad T, Nasim F, Chaudry MU, Umar M (2011) Use of tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement. Orthop Surg Res 6(1):22
37. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W (2009) Use of antifibrinolytic therapy to reduce trans-fusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res 123(5):687-696
38. Senay S, Toraman F, Karabulut H, Alhan C (2010) Efficiency of preoperative tranexamic acid in coronary bypass surgery: an analysis correlated with preoperative clopidogrel use. Heart Surg Forum 13(3):E149-E154
39. Koseki M, Asada N, Uryu H, Takeuchi M, Asakura H, Matsue K (2007) Successful combined use of tranexamic acid and unfrac-tionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis. Int J Hematol 86(5):403-406