Use of Tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement

Journal of Orthopaedic Surgery and Research

Volumn 6, Issue 1, 2011, Pages

  Sepah, Yasir J ^a   Umer, Masood ^b   Ahmad, Tashfeen ^b   Nasim, Faria ^a   Umer Chaudhry, Muhammad ^a   Umar, Muhammad ^b  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; HEMOGLOBIN; TRANEXAMIC ACID;

ARTICLE; BLEEDING; BLOOD TRANSFUSION; COHORT ANALYSIS; COST BENEFIT ANALYSIS; ECONOMICS; FEMALE; HUMAN; KNEE ARTHROPLASTY; KNEE OSTEOARTHRITIS; MALE; METABOLISM; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; RETROSPECTIVE STUDY; RHEUMATOID ARTHRITIS;

ANTIFIBRINOLYTIC AGENTS; ARTHRITIS, RHEUMATOID; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; COHORT STUDIES; COST-BENEFIT ANALYSIS; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POSTOPERATIVE HEMORRHAGE; RETROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 79956217281     PISSN: None     EISSN: 1749799X     Source Type: Journal    
DOI: 10.1186/1749-799X-6-22     Document Type: Article

References (46)

1. Cushner FD, F R. Blood loss in total knee arthroplasty. Clin Orth 1991, 269:98-101.
2. Fragen RJ, S S, Wixson R, et al. Effect of Ketorolac tromethamine on bleeding and requirements for analgesia after total knee arthroplasty. J Bone Joint Surg(Am) 1995, 77:998-1002.
3. Bukart BC, B R, Rorabeck CH, et al. The efficacy of tourniquet release in blood conservation after total knee replacement. Clin Orth 1994, 299:147-52.
4. Karnezis TA, S S, Wixson RL, Reilly P. The hemostatic effects of desmopressin on patients who had total joint arthroplasty. J Bone Joint Surg(Am) 1994, 76:1545-50.
5. Mylod AG, F M, Muser DE, Parsons JR. Perioperative blood loss associated with total knee arthroplasty. J Bone Joint Surg(Am) 1990, 72:1010-2.
6. Fauno P, S O, Rehnberg V, et al. Prophylaxis for the preventiopn of venous thromboembolism after total knee arthroplasty. J Bone Joint Surg(Am) 1994, 76:1814-8.
7. Goodnough LT, V D, Marcus RE. The relationship between hematocrit, blood lost and blood transfused in total knee replacement. Am J Knee Surg 1995, 8:83-7.
8. Klenerman L, M I, Chakrabarti R, et al. Changes in the hemostatic system after application of a tourniquet. Lancet 1977, I:970-2.
9. Benoni G, C A, Petersson C, Fredin H. Does Tranexamic Acid reduces blood loss after total knee arthroplasty?. Am J Knee Surg 1995, 8:88-92.
10. Petaja J, M P, Myllyla G, Vahtera E. Fibrinolysis after application of a pnematic tourniquet. Acta Chir Scand 1987, 153:647-51.
11. Martin JW, W L, Milliano MT, Reedy ME. Post operative blood Retrieval and transfusion in cementless total knee arthroplasty. J Arthroplasty 1992, 7:205-10. 10.1016/0883-5403(92)90019-M, 1613532.
12. Lane GJ, H W, Shah S, Rothman RH, Booth RE, Engh K, Smith P. Simultaneous bilateral versus unilateral total knee replacement arthroplasty. Outcomes Analysis. Clin Orthop 1997, 345:106-12.
13. Nozoe T, M M, Saeki H, Ohga T, Keizo S. Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma. Cancer 2001, 92(7):1913-18. 10.1002/1097-0142(20011001)92:7<1913::AID-CNCR1709>3.0.CO;2-8, 11745265.
14. Brian McClelland MC. Appropriateness and safety of blood transfusion. BMJ 2005, 330:104-105. 10.1136/bmj.330.7483.104, 544413, 15649906.
15. Spanh DR, C M. Eliminating blood transfusions. New aspects and perspectives. Anesthesiology 2000, 93:242-55. 10.1097/00000542-200007000-00035, 10861168.
16. P O, H. Antifibrinolytic therapy with Cyklopropan in connection with prostatectomy: a double blind study. Scand J Urol Nephrol 1969, 3:177-82. 10.3109/00365596909135401, 4912802.
17. Dunn CJ, G K. Tranexamic Acid: a review of its use in surgery and other indications. Drugs 1999, 57:1005-32. 10.2165/00003495-199957060-00017, 10400410.
18. Bekasssy Z, A B. Treatment with fibrinolytic inhibitor tranexamic acid: risk for thrombosis?. Acta Obstet Gynecol Scand 1990, 69:353-4. 10.3109/00016349009036161, 2244469.
19. Kataros D, P M, Snow NJ, Woodland DD, Van Bergan. Tranexamic Acid reduces postbypass blood loss: a double blinded, prospective, randomised study of 210 patients. Ann Thorac Surg 1996, 61:1131-5. 10.1016/0003-4975(96)00022-7, 8607670.
20. Hiippala ST, S L, Wennerstrand MI, Arvela JV, Niemel a HM, M antyl a SK, Kuisma RP, Ylinen JE. Tranexamic Acid radically reduces blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 1997, 84:839-44.
21. Hiippala S, S L, Wennerstrand M. Tranexamic Acid (Cyklopropan) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anesth 1995, 74:534-7.
22. Benoni G, G H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: A prospective, randomized, double blind study of 86 patients. J Bone Joint Surg Br 1996, 78:434-440.
23. Rosenblatt MA. Strategies for minimizing the use of allogeneic blood during orthopedic surgery. Mt Sinai J Med 2002, 69(1-2):83-7.
24. Zufferey P, F M, Laporte S, Decousus H, Mismetti P, Auboyer C, Charles MS, Molliex S. Do Antifibrinolytics Reduce Allogeneic Blood Transfusion in Orthopedic Surgery?. Anesthesiology 2006, 105:1034-46. 10.1097/00000542-200611000-00026, 17065899.
25. Ip, P P, et al. Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. Am J Surg Pathol 2007, 31(8):1215-24. 10.1097/PAS.0b013e318032125e, 17667546.
26. Sethna NF, et al. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology 2005, 102(4):727-32. 10.1097/00000542-200504000-00006, 15791100.
27. Chrishantha Abeysenaa HJdS HIV in South Asia. Medicine 2005, 33(6):42-43. Chrishantha Abeysenaa HJdS.
28. Ali S, T W, Khan A. Viral hepatitis in children. 1998, AFIP Rawalpindi, Pakistan.
29. Linda E, Prescott PS. Global Distribution of Transfusion-Transmitted Virus. NEJM 1998, 339(11):776-777. 10.1056/NEJM199809103391118, 9742036.
30. Mahfooz ur Rahman AGN, Lodhi Y. Transfusion transmitted HIV & HBV infections in Punjab, Pakista. Pakistan Journal of Medical Sciences 2002, 18(1):18-25.
31. Mukherjee Rupali T. India to be largest market for knee, hip replacements., in The Times of India. 2007,
32. Sons F. Number of total knee implants supplied to Pakitan. 2007, Karachi.
33. Aga Khan University Hospital Karachi, Pakistan. Price list. , http://www.aku.edu/AKUH/Patient_Visitor/page6.shtml
34. Gandini G, et al. Preoperative autologous blood donation by 1073 elderly patients undergoing elective surgery: a safe and effective practice. Transfusion 1999, 39(2):174-8. 10.1046/j.1537-2995.1999.39299154732.x, 10037128.
35. Trouern-Trend JJ, et al. A case-controlled multicenter study of vasovagal reactions in blood donors: influence of sex, age, donation status, weight, blood pressure, and pulse. Transfusion 1999, 39(3):316-20. 10.1046/j.1537-2995.1999.39399219291.x, 10204597.
36. Forgie MA, et al. Preoperative autologous donation decreases allogeneic transfusion but increases exposure to all red blood cell transfusion: results of a meta-analysis. International Study of Perioperative Transfusion (ISPOT) Investigators. Arch Intern Med 1998, 158(6):610-6. 10.1001/archinte.158.6.610, 9521225.
37. Sculco TP, Gallina J. Blood management experience: relationship between autologous blood donation and transfusion in orthopedic surgery. Orthopedics 1999, 22(Suppl 1):s129-34.
38. Etchason J, et al. The cost effectiveness of preoperative autologous blood donations. N Engl J Med 1995, 332(11):719-24. 10.1056/NEJM199503163321106, 7854380.
39. Bryson GL, Laupacis A, Wells GA. Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The International Study of Perioperative Transfusion. Anesth Analg 1998, 86(1):9-15.
40. Umlas J, et al. Red cell loss following orthopedic surgery: the case against postoperative blood salvage. Transfusion 1994, 34(5):402-6. 10.1046/j.1537-2995.1994.34594249051.x, 8191564.
41. Lee AG. Ischemic optic neuropathy following lumbar spine surgery. Case report. J Neurosurg 1995, 83(2):348-9. 10.3171/jns.1995.83.2.0348, 7616283.
42. Stevens WR, et al. Ophthalmic complications after spinal surgery. Spine (Phila Pa 1976) 1997, 22(12):1319-24.
43. James ML, Keifer JC. Posterior optic nerve ischemic neuropathy in the setting of phenoxybenzamine therapy after uneventful spinal fusion. J Neurosurg Anesthesiol 2011, 23(2):169-70. 10.1097/ANA.0b013e31820396d6, 21270647.
44. Coyle D, et al. Economic analysis of erythropoietin use in orthopaedic surgery. Transfus Med 1999, 9(1):21-30. 10.1046/j.1365-3148.1999.009001021.x, 10216902.
45. Kasper SM, et al. A retrospective study of the effects of small-dose aprotinin on blood loss and transfusion needs during total hip arthroplasty. Eur J Anaesthesiol 1998, 15(6):669-75. 10.1097/00003643-199811000-00008, 9884852.
46. Royston D, van Haaften N, De Vooght P. Aprotinin; friend or foe? A review of recent medical literature. Eur J Anaesthesiol 2007, 24(1):6-14.