The Effect of Amicar on Perioperative Blood Loss in Idiopathic Scoliosis: The Results of a Prospective, Randomized Double-Blind Study

Spine

Volumn 29, Issue 3, 2004, Pages 233-238

  Florentino Pineda, Ivan ^a   Thompson, George H ^a   Poe Kochert, Connie ^a   Huang, Robert P ^b   Haber, Lawrence L ^c   Blakemore, Laurel C ^d  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b Shriners Hospital for Children   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Amicar (epsilon aminocaproic acid); Idiopathic scoliosis; Perioperative blood loss

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT;

ADOLESCENT; ANESTHESIOLOGICAL TECHNIQUES; ARTICLE; BLEEDING; BLOOD AUTOTRANSFUSION; BONE GRAFT; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IDIOPATHIC SCOLIOSIS; INFUSION PUMP; LENGTH OF STAY; MALE; PEROPERATIVE CARE; PEROPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCOLIOSIS; SPINE FUSION; TREATMENT OUTCOME;

6-AMINOCAPROIC ACID; ADOLESCENT; ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTRAOPERATIVE PERIOD; MALE; PROSPECTIVE STUDIES; SCOLIOSIS; SPINAL FUSION;

EID: 0742304560     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.BRS.0000109883.18015.B9     Document Type: Article

References (26)

1. Guay J, Haig M, Lortie L, et al. Predicting blood loss in surgery for idiopathic scoliosis. Can J Anaesth 1994;41:775-81.
2. McNeill TW, DeWald RL, Kuo KN, et al. Controlled hypotensive anesthesia in scoliosis surgery. J Bone Joint Surg Am 1974;56:1167-72.
3. Patel NJ, Patel BS, Paskin S, et al. Induced moderate hypotensive anesthesia or spinal fusion and Harrington rod instrumentation. J Bone Joint Surg Am 1985;67:1384-7.
4. Phillips WA, Hensinger RN. Control of blood loss during scoliosis surgery. Clin Orthop 1988;229:88-92.
5. Relton JES, Hall JE. An operation frame for spinal fusion. A new apparatus designed to reduce hemorrhage during operation. J Bone Joint Surg Br 1967;49:327.
6. Cowell MR, Swickard JW. Autotransfusion in children's orthopaedics, J Bone Joint Surg 1974;56:908.
7. Cole J, Murray D, Lenke L, et al. Use of Amicar vs Aprotinin during pediatric spinal deformity surgery: can they help decrease blood loss? Presented at: Scoliosis Research Society Annual Meeting; September 18-21, 2002; Seattle, Washington.
8. Florentino-Pineda I, Blakemore LC, Thompson GH, et al. The effect of epsilon aminocaproic acid on perioperative blood loss in patients with idiopathic scoliosis undergoing posterior spinal fusion. A preliminary prospective study. Spine 2001;26:1147-51.
9. Koshhal K, Clark P, Jarvis J, et al. The efficacy of Aprotinin in reducing blood loss in spinal fusion for idiopathic scoliosis. Presented at: Pediatric Orthopaedic Society of North America Annual Meeting; May 1-5, 2001; Cancun, Mexico.
10. Urban MK, Beckman J, Gordon M, et al. The efficacy of antifibrinolytics in the reduction of blood loss during complex adult reconstructive spine surgery. Spine 2001;26:1152-5.
11. Rao BH, Saxena N, Chauhan S, et al. Epsilon aminocaproic acid in paediatric cardiac surgery to reduce postoperative blood loss. Indian J Med Res 2000;111:57-61.
12. Vander Salm TJ, Kaur S, Lancey RA, et al. Reduction of bleeding after heart operations through the prophylactic use of epsilon-aminocaproic acid. J Thoracic Cardiovasc Surg 1996;112:1098-107.
13. Williams GD, Bratton SL, Riley EC, et al. Efficacy of epsilon-aminocaproic acid in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 1999;13:304-8.
14. Bjure J, Grimby G, Nachemson A. Correction of body height in predicting spirometric values in scoliotic patients. Scand J Clin Lab Invest 1968;21:190-2.
15. Normelli H, Sevastik J, Ljung G, et al. Anthropometric data relating to normal and scoliotic Scandinavian girls. Spine 1985;10:123-6.
16. Dunn CJ, Goa KL. Tranexamic acid. A review of its use in surgery and other indications. Drugs 1999;57:1005-32.
17. Harley BJ, Beaupre LD, Jones A, et al. The effect of epsilon aminocaproic acid on blood loss in patients who undergo primary total hip replacement: a pilot study. Can J Surg 2002;45:185-90.
18. Lentchener C, Cottin P, Bouaziz H, et al. Reduction of blood loss and transfusion requirement by aprotinin in posterior lumbar spine fusion. Anesth Analg 1999;89:590-7.
19. Murkin JM, Shannon NA, Bourne RB, et al. Aprotinin decreases blood loss in patients undergoing revision in bilateral total hip arthroplasty. Anesth Analg 1995;80:343-8.
20. Alanay A, Acaroglu E, Özdemir O, et al. Effects of deamino-8-d-arginin vasopressin on blood loss and coagulation factors in scoliosis surgery. A double-blind randomized clinical trial. Spine 1999;24:877-82.
21. Guay J, Reinberg C, Poitras B, et al. A trial of desmopressin to reduce blood loss in patients undergoing spinal fusion for idiopathic scoliosis. Anesth Analg 1992;75:405-10.
22. McCall RE, Bilderback KK. Use of intraveneous Premarin to decrease post-operative blood loss after pediatric scoliosis surgery. Spine 1997;22:1394-7.
23. Isaza J, Liu YK, Holt R. The effect of Premarin on the excessive post operative drainage after posterior lumbosacral vertebral fusion. Poster Exhibit at the Scoliosis Research Society Annual Meeting: September 21-24, 1994; Portland, Oregon.
24. Laupacis A, Ferguson D. Drugs to minimize perioperative blood loss in cardiac surgery: meta-analyses using perioperative blood loss as the outcome. Anesth Analg 1997;85:1258-67.
25. Munoz JJ, Birkmeyer JD, et al. Is epsilon-aminocaproic acid as effective as Aprotinin in reducing bleeding with cardiac surgery? A meta-analysis. Circulation 1999;99:81-89.
26. Slaughter TF, Greenberg CS. Antifibrinolytic drugs and perioperativc hemostasis. Am J Hematol 1997;56:32-36.