Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis

International Journal of Hematology

Volumn 86, Issue 5, 2007, Pages 403-406

  Koseki, Mihoko ^a   Asada, Noboru ^a   Uryu, Hidetaka ^a   Takeuchi, Masami ^a   Asakura, Hidesaku ^b   Matsue, Kosei ^a  

^a Kameda General Hospital   (Japan)

^b KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic myelogenous leukemia (CML); Disseminated intravascular coagulation (DIC); Plasmin 2 plasmin inhibitor complex (PIC); Thrombin antithrombin III complex (TAT); Tranexamic acid (TA); Unfractionated heparin

Indexed keywords

ALPHA 2 ANTIPLASMIN; ANTITHROMBIN III; BCR ABL PROTEIN; CYTARABINE; DANAPAROID; HEPARIN; IMATINIB; MITOXANTRONE; PLASMIN; THROMBIN ANTITHROMBIN COMPLEX; TRANEXAMIC ACID;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BLAST CELL CRISIS; CASE REPORT; CHRONIC MYELOID LEUKEMIA; COLON HEMORRHAGE; COMBINATION CHEMOTHERAPY; CONTINUOUS INFUSION; DISSEMINATED INTRAVASCULAR CLOTTING; FIBRINOLYSIS; FLUID RESUSCITATION; HUMAN; HYPOVOLEMIC SHOCK; LEUKEMIA RELAPSE; MALE; PLASMA TRANSFUSION; SIGMOID; TREATMENT OUTCOME;

ACUTE DISEASE; ADULT; ANTIFIBRINOLYTIC AGENTS; ANTINEOPLASTIC AGENTS; ANTIPLASMIN; ANTITHROMBIN III; BLAST CRISIS; BLOOD TRANSFUSION; BONE MARROW TRANSPLANTATION; COLON; COLONIC DISEASES; DISSEMINATED INTRAVASCULAR COAGULATION; GASTROINTESTINAL HEMORRHAGE; GENES, ABL; HEPARIN; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; PEPTIDE HYDROLASES; PIPERAZINES; PLASMIN; PYRIMIDINES; SHOCK; TRANEXAMIC ACID; TRANSPLANTATION, HOMOLOGOUS;

EID: 38349048606     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.07059     Document Type: Article

References (19)

1. Levi M, Cate HT. Disseminated intravascular coagulation. N Engl J Med. 1999;341:586-592.
2. Tallman MS. Kwaan HC. Reassessing the hematostatic disorder associated with acute promyelocytic leukemia. Blood. 1992;79:543-553.
3. Levi M. Current understanding of disseminated intravascular coagulation. Br J Haematol. 2004;124:567-576.
4. Barbui T, Falanga A. Disseminated intravascular coagulation in acute leukemia. Semin Thromb Hemost. 2001;27:593-604.
5. Hanna BD, Bernstein M, Tranexamic acid in the treatment of Kasabach-Merritt syndrome in infants. Am J Pediatr Hematol Oncol. 1989;11:191-195.
6. Takada A, Takada Y, Mori T, Sakaguchi S. Prevention of severe bleeding by tranexamic acid in a patient with disseminated intravascular coagulation. Thromb Res. 1990;58:101-108.
7. Wada H, Kumeda Y, Ogasawara Z, et al. Plasminogen activators and their inhibitors in leukemic cell homogenates. Am J Hematol. 1993;42:166-170.
8. Robbie L, Berry S, Moir E, et al. Myeloid leukemic cells can lyse fibrin directly. Br J Haematol. 2000;111:524-529.
9. Menell JS, Cesarman GM, Jacovina AT, McLaughlin MA, Leu EA, Hajjar KA. Annexin II and bleeding in acute promyelocytic leukemia. N Engl J Med. 1999;340:994-1004.
10. Asakura H, Jokaji H, Saito M, et al. Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers. Blood Coagul Fibrinolysis. 1994;5:829-832.
11. Asakura H, Sano Y, Yamazaki M, Morishita E, Miyamoto K, Nakao S. Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats: an effect of tranexamic acid. Haematologica. 2004;89:757-758.
12. Avvisati G, ten Cate JW, Büller HR, Mandelli F. Tranexamic acid for control of haemorrhage in acute promyelocytic leukemia. Lancet. 1989;2:122-124.
13. Rodeghiero F, Avvisati G, Castaman G, Barbui T, Mandelli F. Early death and anti-hemorrhagic treatments in acute promyelocytic leukemia: A GIMEMA retrospective study in 268 consecutive patients. Blood. 1990;75:2112-2117.
14. Sanz MA, Martín G, González M, et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monotherapy: a multicenter study by the PETHEMA group. Blood. 2004;103:1237-1243.
15. Hashimoto S, Koike T, Tatewaki W, et al. Fatal thromboembolism in acute promyelocytic leukemia during all-trans-retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage. Leukemia. 1994;8:1113-1115.
16. Ontachi Y, Asakura H, Arahata M, et al. Effect of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm. Circ J. 2005;69:1150-1153.
17. Ontachi Y, Asakura H, Omote M, Yoshida T, Matsui O, Nakao S. Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid. Haematologica. 2005;90(Suppl):ECR29.
18. Kario K, Matsuo T, Kodama K, Matsuo M, Yamamoto K, Kobayashi H. Imbalance between thrombin and plasmin activity in disseminated intravascular coagulation: assessment by the thrombin-antithrombin-III complex/plasmin-alpha- 2-antiplasmin complex ratio. Haemostasis. 1992;22:179-186.
19. Okajima K, Kohno I, Soe G, Okabe H, Takatsuki K, Binder BR. Direct evidence for systemic fibrinogenolysis in patients with acquired alpha 2-plasmin inhibitor deficiency. Am J Hematol. 1994;45:16-24.