Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylation

Toxicology and Applied Pharmacology

Volumn 263, Issue 3, 2012, Pages 360-367

  Cheng, Ya Hsin ^a   Li, Lih Ann ^b   Lin, Pinpin ^b   Cheng, Li Chuan ^b   Hung, Chein Hui ^c   Chang, Nai Wen ^a   Lin, Chingju ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

AhR; Baicalein; Cyclin D1; Oral cancer; Rb

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BAICALEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; LITHIUM CHLORIDE; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL POPULATION; CELL PROLIFERATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MOUTH CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOUTH NEOPLASMS; PHOSPHORYLATION; RECEPTORS, ARYL HYDROCARBON; RETINOBLASTOMA PROTEIN;

EID: 84865431008     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.07.010     Document Type: Article

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