Impact of aryl hydrocarbon receptor (AhR) knockdown on cell cycle progression in human HaCaT keratinocytes

Biological Chemistry

Volumn 392, Issue 7, 2011, Pages 643-651

  Kalmes, Michaela ^a   Hennen, Jenny ^a   Clemens, Judith ^a   Blömeke, Brunhilde ^a  

^a UNIVERSITY OF TRIER   (Germany)

Author keywords

cytochrome P450 1; interleukin 8; physiological AhR function; proliferation; skin cells

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME P450; CYTOCHROME P450 1A1; ETHOXYRESORUFIN DEETHYLASE; RETINOBLASTOMA PROTEIN;

ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; DNA SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; SKIN CELL; WESTERN BLOTTING; WILD TYPE;

CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; DNA; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; KERATINOCYTES; RECEPTORS, ARYL HYDROCARBON; TIME FACTORS;

EID: 79959462242     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2011.067     Document Type: Article

References (51)

1. Abdelrahim, M., Smith, R., 3rd, and Safe, S. (2003). Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Mol. Pharmacol. 63, 1373-1381 (Pubitemid 36627233)
2. Azkargorta, M., Fullaondo, A., Laresgoiti, U., Aloria, K., Infante, A., Arizmendi, J.M., and Zubiaga, A.M. (2010). Differential proteomics analysis reveals a role for E2F2 in the regulation of the Ahr pathway in T lymphocytes. Mol. Cell Proteomics 9, 2184-2194
3. Barhoover, M.A., Hall, J.M., Greenlee, W.F., and Thomas, R.S. (2009). The AHR regulates cell cycle progression in human breast cancer cells via a functional interaction with CDK4 Mol. Pharmacol. 77, 195-201
4. Baron, J.M., Zwadlo-Klarwasser, G., Jugert, F., Hamann, W., Rubben, A., Mukhtar, H., and Merk, H.F. (1998). Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets. Biochem. Pharmacol. 56, 1105-1110 (Pubitemid 28511231)
5. Bonifas, J., Hennen, J., Dierolf, D., Kalmes, M., and Blömeke, B. (2010a). Evaluation of cytochrome p450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers. Toxicol. In Vitro 24, 973-980
6. Bonifas, J., Scheitza, S., Clemens, J., and Blomeke, B. (2010b). Characterization of N-acetyltransferase 1 activity in human keratinocytes and modulation by para-phenylenediamine. J. Pharmacol. Exp. Ther. 334, 318-326
7. Boukamp, P., Petrussevska, R.T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N.E. (1988). Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771 (Pubitemid 18089976)
8. Carvajal-Gonzalez, J.M., Roman, A.C., Cerezo-Guisado, M.I., Rico- Leo, E.M., Martin-Partido, G., and Fernandez-Salguero, P.M. (2009). Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGFb. J. Cell Sci. 122, 1823-1833
9. Chang, C.Y. and Puga, A. (1998). Constitutive activation of the aromatic hydrocarbon receptor. Mol. Cell Biol. 18, 525-535 (Pubitemid 28021063)
10. Chang, X., Fan, Y., Karyala, S., Schwemberger, S., Tomlinson, C.R., Sartor, M.A., and Puga, A. (2007). Ligand-independent regulation of transforming growth factor b1 expression and cell cycle progression by the aryl hydrocarbon receptor. Mol. Cell Biol. 27, 6127-6139 (Pubitemid 47326700)
11. Esser, C., Rannug, A., and Stockinger, B. (2009). The aryl hydrocarbon receptor in immunity. Trends Immunol. 30, 447-454
12. Fernandez-Salguero, P.M., Ward, J.M., Sundberg, J.P., and Gonzalez, F.J. (1997). Lesions of aryl-hydrocarbon receptor-deficient mice. Vet. Pathol. 34, 605-614 (Pubitemid 127470933)
13. Fritsche, E., Schafer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hubenthal, U., Cline, J.E., Hajimiragha, H., Schroeder, P., et al. (2007). Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc. Natl. Acad. Sci. USA 104, 8851-8856 (Pubitemid 47175400)
14. Ge, N.L. and Elferink, C.J. (1998). A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle. J. Biol. Chem. 273, 22708-22713
15. Huang, G. and Elferink, C.J. (2005). Multiple mechanisms are involved in Ah receptor-mediated cell cycle arrest. Mol. Pharmacol. 67, 88-96 (Pubitemid 40069969)
16. Ikuta, T., Kobayashi, Y., and Kawajiri, K. (2004). Cell density regulates intracellular localization of aryl hydrocarbon receptor. J. Biol. Chem. 279, 19209-19216 (Pubitemid 38623352)
17. Ikuta, T., Namiki, T., Fujii-Kuriyama, Y., and Kawajiri, K. (2008). AhR protein trafficking and function in the skin. Biochem. Pharmacol. 77, 588-596
18. Ito, T., Tsukumo, S., Suzuki, N., Motohashi, H., Yamamoto, M., Fujii-Kuriyama, Y., Mimura, J., Lin, T.M., Peterson, R.E., Tohyama, C., et al. (2004). A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest. J. Biol. Chem. 279, 25204-25210 (Pubitemid 38756771)
19. Jain, S., Maltepe, E., Lu, M.M., Simon, C., and Bradfield, C.A. (1998). Expression of ARNT, ARNT2, HIF1a, HIF2a and Ah receptor mRNAs in the developing mouse. Mech. Dev. 73,117-123 (Pubitemid 28218548)
20. Jin, D.Q., Jung, J.W., Lee, Y.S., and Kim, J.A. (2004). 2,3,7,8-etrachlorodibenzo- p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells. Neurosci. Lett. 363, 69-72 (Pubitemid 38639854)
21. Kalmes, M., Neumeyer, A., Rio, P., Hanenberg, H., Fritsche, E., and Blömeke, B. (2006). Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT). Biol. Chem. 387, 1201-1207 (Pubitemid 44402066)
22. Kerkvliet, N.I. (2009). AHR-mediated immunomodulation: the role of altered gene transcription. Biochem. Pharmacol. 77, 746-760
23. Kolluri, S.K., Weiss, C., Koff, A., and Gottlicher, M. (1999). p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13, 1742-1753 (Pubitemid 29325878)
24. Kuchenhoff, A., Seliger, G., Klonisch, T., Tscheudschilsuren, G., Kaltwasser, P., Seliger, E., Buchmann, J., and Fischer, B. (1999). Arylhydrocarbon receptor expression in the human endometrium. Fertil. Steril. 71, 354-360 (Pubitemid 29069917)
25. Levine-Fridman, A., Chen, L., and Elferink, C.J. (2004). Cytochrome P4501A1 promotes G1 phase cell cycle progression by controlling aryl hydrocarbon receptor activity. Mol. Pharmacol. 65, 461-469 (Pubitemid 38134275)
26. Ma, Q. and Whitlock, J.P., Jr. (1996). The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell Biol. 16, 2144-2150 (Pubitemid 26123735)
27. Mace, K., Bowman, E., Vautravers, P., Shields, P., Harris, C., and Pfeifer, A. (1998). Characterization of xenobiotic-metabolizing enzyme expression in human bronchial mucosa and peripheral lung tissues. Eur. J. Cancer 34, 914-920 (Pubitemid 28248506)
28. Marlowe, J.L., Knudsen, E.S., Schwemberger, S., and Puga, A. (2004). The aryl hydrocarbon receptor displaces p300 from E2Fdependent promoters and represses S phase-specific gene expression. J. Biol. Chem. 279, 29013-29022 (Pubitemid 38915771)
29. Marlowe, J.L., Fan, Y., Chang, X., Peng, L., Knudsen, E.S., Xia, Y., and Puga, A. (2008). The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol. Biol. Cell 19, 3263-3271
30. Mitchell, K.A. and Elferink, C.J. (2008). Timing is everything: onsequences of transient and sustained AhR activity. Biochem. Pharmacol. 77, 947-956
31. Nebert, D.W. (1991). Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Mol. Endocrinol. 5, 1203-1214
32. Ortiz de Montellano, P.R., and Mathews, J.M. (1981). Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1- aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct. Biochem. J. 195, 761-764
33. Pang, P.H., Lin, Y.H., Lee, Y.H., Hou, H.H., Hsu, S.P., and Juan, S.H. (2008). Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells. J. Cell Physiol. 215, 161-171
34. Platzer, B., Richter, S., Kneidinger, D., Waltenberger, D., Woisetschlager, M., and Strobl, H. (2009). Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and langerhans dendritic cells. J. Immunol. 183, 66-74
35. Puga, A., Barnes, S.J., Dalton, T.P., Chang, C., Knudsen, E.S., and Maier, M.A. (2000). Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2Fdependent transcription and cell cycle arrest. J. Biol. Chem. 275, 2943-2950 (Pubitemid 30082071)
36. Puga, A., Xia, Y., and Elferink, C. (2002). Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem. Biol. Interact. 141, 117-130 (Pubitemid 35223208)
37. Richter, C.A., Tillitt, D.E., and Hannink, M. (2001). Regulation of subcellular localization of the aryl hydrocarbon receptor (AhR). Arch Biochem. Biophys. 389, 207-217
38. Saini, S., Hirata, H., Majid, S., and Dahiya, R. (2009). Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis. Cancer Res. 69, 7038-7045
39. Santini, R.P., Myrand, S., Elferink, C., and Reiners, J.J., Jr. (2001). Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase. J. Pharmacol. Exp. Ther. 299, 718-728 (Pubitemid 32979687)
40. Shimba, S., Komiyama, K., Moro, I., and Tezuka, M. (2002). Overexpression of the aryl hydrocarbon receptor (AhR) accelerates the cell proliferation of A549 cells. J. Biochem. 132, 795-802 (Pubitemid 35408504)
41. Shimba, S., Hayashi, M., Ohno, T., and Tezuka, M. (2003). Transcriptional regulation of the AhR gene during adipose differentiation. Biol. Pharm. Bull. 26, 1266-1271 (Pubitemid 41656560)
42. Singh, R.K., Gutman, M., Radinsky, R., Bucana, C.D., and Fidler, I.J. (1994). Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res. 54, 3242-3247 (Pubitemid 24208936)
43. Singh, S.S., Hord, N.G., and Perdew, G.H. (1996). Characterization of the activated form of the aryl hydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand. Arch Biochem. Biophys. 329, 47-55 (Pubitemid 26143396)
44. Stevens, E.A., Mezrich, J.D., and Bradfield, C.A. (2009). The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 127, 299-311
45. Strobeck, M.W., Fribourg, A.F., Puga, A., and Knudsen, E.S. (2000). Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest. Oncogene 19, 1857-1867 (Pubitemid 30219028)
46. Takematsu, H. and Tagami, H. (1993). Mode of release of interleukin- 8 from proliferating human epidermal keratinocytes in vitro. Exp. Dermatol. 2, 121-124 (Pubitemid 23344563)
47. Tang, L., Yu, Y., Chen, J., Li, Q., Yan, M., and Guo, Z. (2003). The inhibitory effect of VitD3 on proliferation of keratinocyte cell line HACAT is mediated by down-regulation of CXCR2 expression. Clin. Exp. Dermatol. 28, 416-419 (Pubitemid 36801848)
48. Tauchi, M., Hida, A., Negishi, T., Katsuoka, F., Noda, S., Mimura, J., Hosoya, T., Yanaka, A., Aburatani, H., Fujii-Kuriyama, Y., et al. (2005). Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol. Cell Biol. 25, 9360-9368 (Pubitemid 41507837)
49. Trimarchi, J.M. and Lees, J.A. (2002). Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3, 11-20 (Pubitemid 135709914)
50. Vindelov, L.L., Christensen, I.J., and Nissen, N.I. (1983). A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3, 323-327 (Pubitemid 13087609)
51. Zhu, Y.M., Webster, S.J., Flower, D., and Woll, P.J. (2004). Interleukin- 8/CXCL8 is a growth factor for human lung cancer cells. Br. J. Cancer 91, 1970-1976 (Pubitemid 40065527)