β-endorphin antagonizes the effects of α-MSH on food intake and body weight

Endocrinology

Volumn 153, Issue 9, 2012, Pages 4246-4255

  Dutia, Roxanne ^a   Meece, Kana ^a   Dighe, Shveta ^a   Kim, Andrea J ^a   Wardlaw, Sharon L ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFAMELANOTIDE; BETA ENDORPHIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENERGY BALANCE; FEEDING BEHAVIOR; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; TREATMENT DURATION; WEIGHT GAIN;

ALPHA-MSH; ANIMALS; BETA-ENDORPHIN; BODY WEIGHT; EATING; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84865423276     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1166     Document Type: Article

References (51)

1. Lee M, Wardlaw SL 2007 The central melanocortin system and the regulation of energy balance. Front Biosci 12:3994-4010
2. Cone RD 2006 Studies on the physiological functions of the melanocortin system. Endocr Rev 27:736-749 (Pubitemid 44936057)
3. McMinn JE, Wilkinson CW, Havel PJ, Woods SC, Schwartz MW 2000 Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression. Am J Physiol Regul Integr Comp Physiol 279:R695-R703
4. Seeley RJ, Burklow ML, Wilmer KA, Matthews CC, Reizes O, McOsker CC, Trokhan DP, Gross MC, Sheldon RJ 2005 The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity. Endocrinology 146:3732-3738 (Pubitemid 41175740)
5. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS 2002 Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 51:1337-1345 (Pubitemid 34826597)
6. Lee M, Kim A, Chua Jr SC, Obici S, Wardlaw SL 2007 Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293:E121-E131 (Pubitemid 47105925)
7. Silva RM, Hadjimarkou MM, Rossi GC, Pasternak GW, Bodnar RJ 2001 β-Endorphin-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. J Pharmacol Exp Ther 297:590-596 (Pubitemid 32377989)
8. Kieffer BL, Evans CJ 2009 Opioid receptors: from binding sites to visible molecules in vivo. Neuropharmacology 56(Suppl 1):205-212
9. Bodnar RJ 2004 Endogenous opioids and feeding behavior: a 30-year historical perspective. Peptides 25:697-725 (Pubitemid 38681072)
10. Grossman HC, Hadjimarkou MM, Silva RM, Giraudo SQ, Bodnar RJ 2003 Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats. Brain Res 991:240-244 (Pubitemid 37297953)
11. Leibowitz SF, Hor L 1982 Endorphinergic and α-noradrenergic systems in the paraventricular nucleus: effects on eating behavior. Peptides 3:421-428 (Pubitemid 12022685)
12. Tabarin A, Diz-Chaves Y, Carmona Mdel C, Catargi B, Zorrilla EP, Roberts AJ, Coscina DV, Rousset S, Redonnet A, Parker GC, Inoue K, Ricquier D, Pénicaud L, Kieffer BL, Koob GF 2005 Resistance to diet-induced obesity in μ-opioid receptor-deficient mice: evidence for a "thrifty gene." Diabetes 54:3510-3516 (Pubitemid 43334343)
13. Appleyard SM, Hayward M, Young JI, Butler AA, Cone RD, Rubinstein M, Low MJ 2003 A role for the endogenous opioid β-endorphin in energy homeostasis. Endocrinology 144:1753-1760 (Pubitemid 36543312)
14. Hayward MD, Pintar JE, Low MJ 2002 Selective reward deficit in mice lacking β-endorphin and enkephalin. J Neurosci 22:8251-8258 (Pubitemid 35379130)
15. Bouret S, Prevot V, Croix D, Jégou S, Vaudry H, Stefano GB, Beauvillain JC, Mitchell V 1999 μ-Opioid receptor mRNA expression in proopiomelanocortin neurons of the rat arcuate nucleus. Brain Res Mol Brain Res 70:155-158 (Pubitemid 29278618)
16. Zheng SX, Bosch MA, Rønnekleiv OK 2005 μ-Opioid receptor mRNA expression in identified hypothalamic neurons. J Comp Neurol 487:332-344 (Pubitemid 40734129)
17. Barnes MJ, Argyropoulos G, Bray GA 2010 Preference for a high fat diet, but not hyperphagia following activation of μ opioid receptors is blocked in AgRP knockout mice. Brain Res 1317:100-107
18. Nicolas P, Li CH 1985 β-Endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc Natl Acad Sci USA 82:3178-3181 (Pubitemid 15029569)
19. Loh HH, Tseng LF, Wei E, Li CH 1976 β-Endorphin is a potent analgesic agent. Proc Nat Acad Sci USA 73:2895-2898
20. Sandman CA, Kastin AJ 1981 Intraventricular administration of MSH induces hyperalgesia in rats. Peptides 2:231-233 (Pubitemid 11030849)
21. Contreras PC, Takemori AE 1984 Antagonism of morphine-induced analgesia, tolerance and dependence by α-melanocyte-stimulating hormone. J Pharmacol Exp Ther 229:21-26 (Pubitemid 14082905)
22. Wardlaw SL, Smeal MM, Markowitz CE 1986 Antagonism of β-endorphin-induced prolactin release by α-melanocyte-stimulating hormone and corticotropin-like intermediate lobe peptide. Endocrinology 119:112-118 (Pubitemid 16100715)
23. Wardlaw SL, Ferin M 1990 Interaction between β-endorphin and α-melanocyte-stimulating hormone in the control of prolactin and luteinizing hormone secretion in the primate. Endocrinology 126: 2035-2040 (Pubitemid 20139751)
24. Khorram O, McCann SM 1986 Interaction of α-melanocyte-stimulating hormone with β-endorphin to influence anterior pituitary hormone secretion in the female rat. Endocrinology 119:1071-1075 (Pubitemid 16053702)
25. Hughes AM, Everitt BJ, Herbert J 1988 The effects of simultaneous or separate infusions of some pro-opiomelanocortin-derived peptides (β-endorphin, melanocyte stimulating hormone, and corticotrophin-like intermediate polypeptide) and their acetylated derivatives upon sexual and ingestive behaviour of male rats. Neuroscience 27:689-698
26. Wardlaw SL 2011 Hypothalamic proopiomelanocortin processing and the regulation of energy balance. Eur J Pharmacol 660:213-219
27. Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, Diano S 2009 Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents. J Clin Invest 119:2291-2303
28. Lee M, Kim A, Conwell IM, Hruby V, Mayorov A, Cai M, Wardlaw SL 2008 Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression. Peptides 29:440-447
29. Sanger DJ, McCarthy PS 1980 Differential effects of morphine on food and water intake in food deprived and freely-feeding rats. Psychopharmacology 72:103-106 (Pubitemid 11197772)
30. McLean S, Hoebel BG 1983 Feeding induced by opiates injected into the paraventricular hypothalamus. Peptides 4:287-292 (Pubitemid 13051286)
31. Bhakthavatsalam P, Leibowitz SF 1986 Morphine-elicited feeding: diurnal rhythm, circulating corticosterone and macronutrient selection. Pharmacol Biochem Behav 24:911-917 (Pubitemid 16074769)
32. Low MJ, Hayward MD, Appleyard SM, Rubinstein M 2003 State-dependent modulation of feeding behavior by proopiomelanocortin-derived β-endorphin. Ann NY Acad Sci 994:192-201 (Pubitemid 36793867)
33. Tseng LF, Loh HH, Li CH 1977 Human β-endorphin: development of tolerance and behavioral activity in rats. Biochem Biophys Res Commun 74:390-396 (Pubitemid 8022727)
34. Bhargava HN 1981 Inhibition of tolerance to the pharmacological effects of human β-endorphin by prolyl-leucyl-glycinamide and cyclo(leucylglycine) in the rat. J Pharmacol Exp Ther 218:404-408 (Pubitemid 11044115)
35. Wilson BD, Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ, Barsh GS 1999 Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. Endocrinology 140: 2387-2397 (Pubitemid 30636480)
36. Korner J, Savontaus E, Chua Jr SC, Leibel RL, Wardlaw SL 2001 Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J Neuroendocrinol 13:959-966 (Pubitemid 33014813)
37. Yang Y, Atasoy D, Su HH, Sternson SM 2011 Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 146:992-1003
38. Brugman S, Clegg DJ, Woods SC, Seeley RJ 2002 Combined blockade of both μ- and κ-opioid receptors prevents the acute orexigenic action of Agouti-related protein. Endocrinology 143:4265-4270 (Pubitemid 35239557)
39. Kelly MJ, Loose MD, Ronnekleiv OK 1990 Opioids hyperpolarize β-endorphin neurons via μ-receptor activation of a potassium conductance. Neuroendocrinology 52:268-275 (Pubitemid 20260129)
40. Markowitz CE, Berkowitz KM, Jaffe SB, Wardlaw SL 1992 Effect of opioid receptor antagonism on proopiomelanocortin peptide levels and gene expression in the hypothalamus. Mol Cell Neurosci 3:184-190
41. Pennock RL, Hentges ST 2011 Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons. J Neurosci 31:281-288
42. Levine AS, Billington CJ 1989 Opioids. Are they regulators of feeding? Ann NY Acad Sci 575:209-219; discussion 219-220
43. Gosnell BA, Krahn DD 1993 The effects of continuous morphine infusion on diet selection and body weight. Physiol Behav 54:853-859 (Pubitemid 23303857)
44. Yanagita K, Shiraishi J, Fujita M, Bungo T 2008 Effects of N-terminal fragments of β-endorphin on feeding in chicks. Neurosci Lett 442:140-142
45. Jaffe SB, Sobieszczyk S, Wardlaw SL 1994 Effect of opioid antagonism on β-endorphin processing and proopiomelanocortin-peptide release in the hypothalamus. Brain Res 648:24-31 (Pubitemid 24171569)
46. Berman Y, Mzhavia N, Polonskaia A, Devi LA 2001 Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. J Biol Chem 276: 1466-1473 (Pubitemid 32096579)
47. Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D2009 The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 15:1195-1201
48. Cone RD, Mountjoy KG, Robbins LS, Nadeau JH, Johnson KR, Roselli-Rehfuss L, Mortrud MT 1993 Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann NY Acad Sci 680:342-363 (Pubitemid 23201025)
49. Pritchard LE, White A 2007 Neuropeptide processing and its impact on melanocortin pathways. Endocrinology 148:4201-4207 (Pubitemid 47295669)
50. Höftberger R, Kunze M, Voigtländer T, Unterberger U, Regelsberger G, Bauer J, Aboul-Enein F, Garzuly F, Forss-Petter S, Bernheimer H, Berger J, Budka H 2010 Peroxisomal localization of the proopiomelanocortin- derived peptides β-lipotropin and β-endorphin. Endocrinology 151:4801-4810
51. Perello M, Stuart R, Nillni EA 2008 Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway. J Biol Chem 283:19936-19947