Antiplatelet effect of phloroglucinol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A 2 production

Toxicology and Applied Pharmacology

Volumn 263, Issue 3, 2012, Pages 287-295

  Chang, Mei Chi ^a   Chang, Hsiao Hua ^b   Chan, Chiu Po ^c   Chou, Han Yi ^b   Chang, Bei En ^b   Yeung, Sin Yuet ^c   Wang, Tong Mei ^b   Jeng, Jiiang Huei ^b  

^a CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Anti inflammatory; Antiplatelet; Cyclooxygenase; Phloroglucinol; Platelet aggregation; Reactive oxygen species

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHLOROGLUCINOL; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; THROMBOXANE A2; THROMBOXANE B2;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; FIBROBLAST; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED ICR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHLOROGLUCINOL; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THROMBOXANE A2;

MUS;

EID: 84865410703     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.06.021     Document Type: Article

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