The mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase

European Journal of Pharmacology

Volumn 584, Issue 2-3, 2008, Pages 361-367

  Kim, Sung Dae ^a   Lee, In Kyoung ^b   Lee, Whi Min ^a   Cho, Jae Youl ^c   Park, Hwa Jin ^d   Oh, Jae Wook ^e   Park, Seung Chun ^a   Kim, Sang Keun ^f   Kwak, Yi Seong ^g   Yun, Bong Sik ^b   Rhee, Man Hee ^a  

^a Kyungpook National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Kangwon National University   (South Korea)

^d Inje University   (South Korea)

^e Chosun University   (South Korea)

^f Chungnam National University   (South Korea)

^g Bio Research Group   (South Korea)

Author keywords

Ca2+ i; ADP; Collagen; Davallialactone; ERK2; Inonotus xeranticus; p38 MAPK; Platelet aggregation; Thrombin

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; COLLAGEN; DAVALLIALACTONE; GLYCOPROTEIN VI; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 3; PURINERGIC P2Y RECEPTOR; THROMBIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; FLUOROMETRY; IMMUNOBLOTTING; MUSHROOM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; CALCIUM SIGNALING; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; LACTONES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOTYROSINE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; THROMBIN;

EID: 41349108242     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.008     Document Type: Article

References (54)

1. Al-Fatimi M., Wurster M., Kreisel H., and Lindequist U. Antimicrobial, cytotoxic and antioxidant activity of selected basidiomycetes from Yemen. Pharmazie 60 (2005) 776-780
2. Awadh Ali N.A., Mothana R.A., Lesnau A., Pilgrim H., and Lindequist U. Antiviral activity of Inonotus hispidus. Fitoterapia 74 (2003) 483-485
3. Begonja A.J., Gambaryan S., Geiger J., Aktas B., Pozgajova M., Nieswandt B., and Walter U. Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood 106 (2005) 2757-2760
4. Begonja A.J., Teichmann L., Geiger J., Gambaryan S., and Walter U. Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS. Blood Cells Mol. Diseases 36 (2006) 166-170
5. Borsch-Haubold A.G., Kramer R.M., and Watson S.P. Cytosolic phospholipase A2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase. J. Biol. Chem. 270 (1995) 25885-25892
6. Bugaud F., Nadal-Wollbold F., Levy-Toledano S., Rosa J.P., and Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood 94 (1999) 3800-3805
7. Burczyk J., Gawron A., Slotwinska M., Smietana B., and Terminska K. Antimitotic activity of aqueous extracts of Inonotus obliquus. Boll. Chim. Farm. 135 (1996) 306-309
8. Chen J., De S., Damron D.S., Chen W.S., Hay N., and Byzova T.V. Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood 104 (2004) 1703-1710
9. Cho H.J., Cho J.Y., Rhee M.H., Lim C.R., and Park H.J. Cordycepin (3 ́-deoxyadenosine) inhibits human platelet aggregation induced by U46619, a TXA2 analogue. J. Pharm. Pharmacol. 58 (2006) 1677-1682
10. Daniel J.L., Dangelmaier C.A., Selak M., and Smith J.B. ADP stimulates IP3 formation in human platelets. FEBS Lett. 206 (1986) 299-303
11. Garcia A., Shankar H., Murugappan S., Kim S., and Kunapuli S.P. Regulation and functional consequences of ADP receptor-mediated ERK2 activation in platelets. Biochem. J. 404 (2007) 299-308
12. Grenache D.G., Coleman T., Semenkovich C.F., Santoro S.A., and Zutter M.M. Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 2104-2109
13. Hers I., Berlanga O., Tiekstra M.J., Kamiguti A.S., Theakston R.D., and Watson S.P. Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets. Eur. J. Biochem. 267 (2000) 2088-2097
14. Holmsen H. Significance of testing platelet functions in vitro. Eur J Clin Invest. 24 (1994) 3-8
15. Huo Y., and Ley K.F. Role of platelets in the development of atherosclerosis. Trends Cardiovasc. Med. 14 (2004) 18-22
16. Jackson S.P., Yap C.L., and Anderson K.E. Phosphoinositide 3-kinases and the regulation of platelet function. Biochem. Soc. Trans. 32 (2004) 387-392
17. Jarosz A., Skorska M., Rzymowska J., Kochmanska-Rdest J., and Malarczyk E. Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells. Acta. Biochim. Pol. 37 (1990) 149-151
18. Kau J.H., Sun D.S., Tsai W.J., Shyu H.F., Huang H.H., Lin H.C., and Chang H.H. Antiplatelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogen-activated protein kinase pathways in the platelets. J. Infect. Dis. 192 (2005) 1465-1474
19. Kim S.D., Park S.K., Cho J.Y., Park H.J., Lim J.H., I., Y.H., Park S.C., Lee K.Y., Kim S.K., and Rhee M.H. Surfactin C inhibits platelet aggregation. J. Pharmac. Pharmacol. 58 (2006) 867-870
20. Kim Y.O., Park H.W., Kim J.H., Lee J.Y., Moon S.H., and Shin C.S. Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus. Life Sci. 79 (2006) 72-80
21. Kramer R.M., Roberts E.F., Strifler B.A., and Johnstone E.M. Thrombin induces activation of p38 MAP kinase in human platelets. J Biol Chem. 270 (1995) 27395-27398
22. Kuliopulos A., Mohanlal R., and Covic L. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb. Haemost. 92 (2004) 1387-1393
23. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
24. Leclerc J.R. Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions. Crit. Care Med. 30 (2002) S332-S340
25. Lee I.K., Seok S.J., Kim W.K., and Yun B.S. Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity. J. Nat. Prod. 69 (2006) 299-301
26. Lee I.K., and Yun B.S. Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity. Bioorg. Med. Chem. Lett. 16 (2006) 2376-2379
27. Li Z., Zhang G., Feil R., Han J., and Du X. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood 107 (2006) 965-972
28. Loiko E.N., Samal A.B., and Shulyakovskaya S.M. H2O2-induced platelet aggregation and increase in intracellular Ca2+ concentration are blocked by inhibitors of intracellular signaling. Biochemistry (Mosc.) 68 (2003) 1210-1216
29. Lull C., Wichers H.J., and Savelkoul H.F. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediat. Inflamm. 2005 (2005) 63-80
30. Mazharian A., Roger S., Maurice P., Berrou E., Popoff M.R., Hoylaerts M.F., Fauvel-Lafeve F., Bonnefoy A., and Bryckaert M. Differential involvement of ERK2 and p38 in platelet adhesion to collagen. J. Biol. Chem. 280 (2005) 26002-26010
31. McNicol A., and Jackson E.C. Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human platelets. Biochem. Pharmacol. 65 (2003) 1243-1250
32. Nadal F., Levy-Toledano S., Grelac F., Caen J.P., Rosa J.P., and Bryckaert M. Negative regulation of mitogen-activated protein kinase activation by integrin alphaIIbbeta3 in platelets. J. Biol. Chem. 272 (1997) 22381-22384
33. Olas B., Nowak P., Kolodziejczyk J., and Wachowicz B. The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thromb. Res. 113 (2004) 399-406
34. Park Y.M., Won J.H., Kim Y.H., Choi J.W., Park H.J., and Lee K.T. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus. J. Ethnopharmacol. 101 (2005) 120-128
35. Pignatelli P., Pulcinelli F.M., Celestini A., Lenti L., Ghiselli A., Gazzaniga P.P., and Violi F. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am. J. Clin. Nutr. 72 (2000) 1150-1155
36. Pignatelli P., Pulcinelli F.M., Lenti L., Gazzaniga P.P., and Violi F. Vitamin E inhibits collagen-induced platelet activation by blunting hydrogen peroxide. Arterioscler. Thromb. Vasc. Biol. 19 (1999) 2542-2547
37. Raghavan S.A., Sharma P., and Dikshit M. Role of ascorbic acid in the modulation of inhibition of platelet aggregation by polymorphonuclear leukocytes. Thromb. Res. 110 (2003) 117-126
38. Redondo P.C., Jardin I., Hernandez-Cruz J.M., Pariente J.A., Salido G.M., and Rosado J.A. Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients. Biochem. Biophys. Res. Commun. 333 (2005) 794-802
39. Rink T.J., and Sage S.O. Calcium signaling in human platelets. Annu. Rev. Physiol. 52 (1990) 431-449
40. Roger S., Pawlowski M., Habib A., Jandrot-Perrus M., Rosa J.P., and Bryckaert M. Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation. FEBS Lett. 556 (2004) 227-235
41. Rosado J.A., and Sage S.O. Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. J. Biol. Chem. 276 (2001) 15659-15665
42. Rosado J.A., and Sage S.O. The ERK cascade, a new pathway involved in the activation of store-mediated calcium entry in human platelets. Trends Cardiovasc. Med. 12 (2002) 229-234
43. Saklatvala J., Rawlinson L., Waller R.J., Sarsfield S., Lee J.C., Morton L.F., Barnes M.J., and Farndale R.W. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J. Biol. Chem. 271 (1996) 6586-6589
44. Savage B., Cattaneo M., and Ruggeri Z.M. Mechanisms of platelet aggregation. Curr. Opin. Hematol. 8 (2001) 270-276
45. Schaeffer J., and Blaustein M.P. Platelet free calcium concentrations measured with fura-2 are influenced by the transmembrane sodium gradient. Cell Calcium 10 (1989) 101-113
46. Seo S.Y., Sharma V.K., and Sharma N. Mushroom tyrosinase: recent prospects. J. Agric. Food Chem. 51 (2003) 2837-2853
47. Shankar H., Garcia A., Prabhakar J., Kim S., and Kunapuli S.P. P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. J. Thromb. Haemost. 4 (2006) 638-647
48. Shattil S.J., Kashiwagi H., and Pampori N. Integrin signaling: the platelet paradigm. Blood 91 (1998) 2645-2657
49. Smith J.B., Selak M.A., Dangelmaier C., and Daniel J.L. Cytosolic calcium as a second messenger for collagen-induced platelet responses. Biochem. J. 288 (1992) 925-929
50. Stojanovic A., Marjanovic J.A., Brovkovych V.M., Peng X., Hay N., Skidgel R.A., and Du X. A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. J. Biol. Chem. 281 (2006) 16333-16339
51. Stouffer G.A., and Smyth S.S. Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1971-1978
52. Sullivan R., Smith J.E., and Rowan N.J. Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine. Perspect. Biol. Med. 49 (2006) 159-170
53. Thisoda P., Rangkadilok N., Pholphana N., Worasuttayangkurn L., Ruchirawat S., and Satayavivad J. Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation. Eur. J. Pharmacol. 553 (2006) 39-45
54. Wasser S.P., and Weis A.L. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit. Rev. Immunol. 19 (1999) 65-96