메뉴 건너뛰기




Volumn 4, Issue 4, 2012, Pages 699-704

Red clover extract exerts antidiabetic and hypolipidemic effects in db/db mice

Author keywords

Diabetes mellitus; Fatty acid synthase; Lipid homeostasis; Peroxisome proliferator activated receptors; Red clover extract; Type

Indexed keywords

ACETYL COENZYME A; ACETYL COENZYME A OXIDASE; APOLIPOPROTEIN A5; APOLIPOPROTEIN C3; BIOCHANIN A; CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; CHOLESTEROL; DAIDZEIN; FATTY ACID SYNTHASE; FORMONONETIN; GENISTEIN; GLUCOKINASE; GLUCOSE; LIPID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RED CLOVER EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84865355087     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.658     Document Type: Article
Times cited : (12)

References (32)
  • 1
    • 58149125606 scopus 로고    scopus 로고
    • Health benefits of isoflavones in functional foods? Proteomic and metabonomic advances
    • Wong MC, Emery PW, Preedy VR and Wiseman H: Health benefits of isoflavones in functional foods? Proteomic and metabonomic advances. Inflammopharmacology 16: 235-239, 2008.
    • (2008) Inflammopharmacology , vol.16 , pp. 235-239
    • Wong, M.C.1    Emery, P.W.2    Preedy, V.R.3    Wiseman, H.4
  • 2
    • 33645000494 scopus 로고    scopus 로고
    • Pharmaceutical prospects of phytoestrogens
    • Usui T: Pharmaceutical prospects of phytoestrogens. Endocr J 53: 7-20, 2006.
    • (2006) Endocr J , vol.53 , pp. 7-20
    • Usui, T.1
  • 3
    • 0036895683 scopus 로고    scopus 로고
    • Beneficial role of dietary phytoestrogens in obesity and diabetes
    • Bhathena SJ and Velasquez MT: Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 76: 1191-1201, 2002.
    • (2002) Am J Clin Nutr , vol.76 , pp. 1191-1201
    • Bhathena, S.J.1    Velasquez, M.T.2
  • 4
    • 33748065969 scopus 로고    scopus 로고
    • Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats
    • Lee JS: Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sci 79: 1578-1584, 2006.
    • (2006) Life Sci , vol.79 , pp. 1578-1584
    • Lee, J.S.1
  • 5
    • 0037657668 scopus 로고    scopus 로고
    • Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells
    • Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA and ShayN: Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 133: 1238-1243, 2003.
    • (2003) J Nutr , vol.133 , pp. 1238-1243
    • Mezei, O.1    Banz, W.J.2    Steger, R.W.3    Peluso, M.R.4    Winters, T.A.5    Shay, N.6
  • 6
    • 0036782541 scopus 로고    scopus 로고
    • Beneficial effects of soy phytoestrogen intake in postmenopausal women with type2 diabetes
    • Jayagopal V, Albertazzi P, Kilpatrick ES, et al: Beneficial effects of soy phytoestrogen intake in postmenopausal women with type2 diabetes. Diabetes Care 25: 1709-1714, 2002.
    • (2002) Diabetes Care , vol.25 , pp. 1709-1714
    • Jayagopal, V.1    Albertazzi, P.2    Kilpatrick, E.S.3
  • 7
    • 20144385339 scopus 로고    scopus 로고
    • Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese typeII DM patients: Relative effects on weight loss, metabolic parameters, and C-reactive protein
    • Li Z, Hong K, Saltsman P, et al: Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese typeII DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr 59: 411-418, 2005.
    • (2005) Eur J Clin Nutr , vol.59 , pp. 411-418
    • Li, Z.1    Hong, K.2    Saltsman, P.3
  • 9
    • 34447129331 scopus 로고    scopus 로고
    • Effects of isoflavone dietary supplementation on cardiovascular risk factors in type 2 diabetes
    • González S, Jayagopal V, Kilpatrick ES, Chapman T and AtkinSL: Effects of isoflavone dietary supplementation on cardiovascular risk factors in type 2 diabetes. Diabetes Care 30: 1871-1873, 2007.
    • (2007) Diabetes Care , vol.30 , pp. 1871-1873
    • González, S.1    Jayagopal, V.2    Kilpatrick, E.S.3    Chapman, T.4    Atkin, S.L.5
  • 10
    • 84861810610 scopus 로고    scopus 로고
    • Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα
    • Qiu L, Ye H, Chen L, Hong Y, Zhong F and Zhang T: Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα. Phytother Res 26: 860-864, 2012.
    • (2012) Phytother Res , vol.26 , pp. 860-864
    • Qiu, L.1    Ye, H.2    Chen, L.3    Hong, Y.4    Zhong, F.5    Zhang, T.6
  • 11
    • 11144310564 scopus 로고    scopus 로고
    • An overview on biological mechanisms of PPARs
    • Kota BP, Huang TH and Roufogalis BD: An overview on biological mechanisms of PPARs. Pharmacol Res 51: 85-94, 2005.
    • (2005) Pharmacol Res , vol.51 , pp. 85-94
    • Kota, B.P.1    Huang, T.H.2    Roufogalis, B.D.3
  • 12
    • 33645512781 scopus 로고    scopus 로고
    • Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro
    • Shen P, Liu MH, Ng TY, Chan YH and Yong EL: Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. J Nutr 136: 899-905, 2006.
    • (2006) J Nutr , vol.136 , pp. 899-905
    • Shen, P.1    Liu, M.H.2    Ng, T.Y.3    Chan, Y.H.4    Yong, E.L.5
  • 13
    • 24344468717 scopus 로고    scopus 로고
    • Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
    • Inoue M, Ohtake T, Motomura W, et al: Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun 336: 215-222, 2005.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 215-222
    • Inoue, M.1    Ohtake, T.2    Motomura, W.3
  • 14
    • 0842307302 scopus 로고    scopus 로고
    • Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma
    • Kim SY, Kim HI, Park SK, et al: Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma. Diabetes 53 (Suppl 1): S66-S70, 2004.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Kim, S.Y.1    Kim, H.I.2    Park, S.K.3
  • 15
    • 77949405407 scopus 로고    scopus 로고
    • Red clover extract: A source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages
    • Mueller M, Hobiger S and Jungbauer A: Red clover extract: a source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages. Menopause 17: 379-387, 2010.
    • (2010) Menopause , vol.17 , pp. 379-387
    • Mueller, M.1    Hobiger, S.2    Jungbauer, A.3
  • 16
    • 84855243116 scopus 로고    scopus 로고
    • BiochaninA ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated macrophages by a PPARγ-dependent pathway
    • Qiu L, Lin B, Lin Z, Lin Y, Lin M and Yang X: BiochaninA ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated macrophages by a PPARγ-dependent pathway. Mol Med Report 5: 217-222, 2012.
    • (2012) Mol Med Report , vol.5 , pp. 217-222
    • Qiu, L.1    Lin, B.2    Lin, Z.3    Lin, Y.4    Lin, M.5    Yang, X.6
  • 17
    • 33646776061 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance
    • Guo L and Tabrizchi R: Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance. Pharmacol Ther 111: 145-173, 2006.
    • (2006) Pharmacol Ther , vol.111 , pp. 145-173
    • Guo, L.1    Tabrizchi, R.2
  • 18
    • 67749137209 scopus 로고    scopus 로고
    • Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling
    • Ronis MJ, Chen Y, Badeaux J and Badger TM: Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling. J Nutr 139: 1431-1438, 2009.
    • (2009) J Nutr , vol.139 , pp. 1431-1438
    • Ronis, M.J.1    Chen, Y.2    Badeaux, J.3    Badger, T.M.4
  • 19
    • 34547650833 scopus 로고    scopus 로고
    • Effects of dietary red clover on blood factors and cardiovascular fatty streak formation in hypercholesterolemic rabbits
    • Asgary S, Moshtaghian J, Naderi G, et al: Effects of dietary red clover on blood factors and cardiovascular fatty streak formation in hypercholesterolemic rabbits. Phytother Res 21: 768-770, 2007.
    • (2007) Phytother Res , vol.21 , pp. 768-770
    • Asgary, S.1    Moshtaghian, J.2    Naderi, G.3
  • 20
    • 33746596198 scopus 로고    scopus 로고
    • Soy and red clover for mid-life and aging
    • Geller SE and Studee L: Soy and red clover for mid-life and aging. Climacteric 9: 245-263, 2006.
    • (2006) Climacteric , vol.9 , pp. 245-263
    • Geller, S.E.1    Studee, L.2
  • 21
    • 24744441935 scopus 로고    scopus 로고
    • Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: A pilot trial
    • Lukaczer D, Darland G, Tripp M, et al: Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Altern Ther Health Med 11: 60-65, 2005.
    • (2005) Altern Ther Health Med , vol.11 , pp. 60-65
    • Lukaczer, D.1    Darland, G.2    Tripp, M.3
  • 23
    • 33750634145 scopus 로고    scopus 로고
    • Comparison between phytoestrogens and estradiol in the prevention of atheroma in ovariectomized cholesterol-fed rabbits
    • Haines C, James A, Sahota D, et al: Comparison between phytoestrogens and estradiol in the prevention of atheroma in ovariectomized cholesterol-fed rabbits. Climacteric 9: 430-436, 2006.
    • (2006) Climacteric , vol.9 , pp. 430-436
    • Haines, C.1    James, A.2    Sahota, D.3
  • 24
    • 0034283535 scopus 로고    scopus 로고
    • The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia
    • Howes JB, Sullivan D, Lai N, et al: The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia. Atherosclerosis 152: 143-147, 2000.
    • (2000) Atherosclerosis , vol.152 , pp. 143-147
    • Howes, J.B.1    Sullivan, D.2    Lai, N.3
  • 25
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    • Lefebvre P, Chinetti G, Fruchart JC and Staels B: Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 116: 571-580, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.C.3    Staels, B.4
  • 26
    • 0029759110 scopus 로고    scopus 로고
    • Transcriptional control of triglyceride metabolism: Fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR
    • Auwerx J, Schoonjans K, Fruchart JC and StaelsB: Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR. Atherosclerosis 124 (Suppl): S29-S37, 1996.
    • (1996) Atherosclerosis , vol.124 , Issue.SUPPL.
    • Auwerx, J.1    Schoonjans, K.2    Fruchart, J.C.3    Staels, B.4
  • 27
    • 0038043229 scopus 로고    scopus 로고
    • Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators
    • Vu-Dac N, Gervois P, Jakel H, et al: Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J Biol Chem 278: 17982-17985, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 17982-17985
    • Vu-Dac, N.1    Gervois, P.2    Jakel, H.3
  • 28
    • 47749155983 scopus 로고    scopus 로고
    • Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis
    • Qiu L, Wu X, Chau JF, et al: Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis. J Biol Chem 283: 17175-17183, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 17175-17183
    • Qiu, L.1    Wu, X.2    Chau, J.F.3
  • 29
    • 0030931047 scopus 로고    scopus 로고
    • Regulation of fatty acid synthase (FAS)
    • Semenkovich CF: Regulation of fatty acid synthase (FAS). Prog Lipid Res 36: 43-53, 1997.
    • (1997) Prog Lipid Res , vol.36 , pp. 43-53
    • Semenkovich, C.F.1
  • 30
    • 0032892175 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
    • Horton JD and Shimomura I: Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 10: 143-150, 1999.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 143-150
    • Horton, J.D.1    Shimomura, I.2
  • 31
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL and Brown MS: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 32
    • 34247891519 scopus 로고    scopus 로고
    • Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells
    • Shin ES, Lee HH, Cho SY, Park HW, Lee SJ and LeeTR: Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J Nutr 137: 1127-1131, 2007.
    • (2007) J Nutr , vol.137 , pp. 1127-1131
    • Shin, E.S.1    Lee, H.H.2    Cho, S.Y.3    Park, H.W.4    Lee, S.J.5    Lee, T.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.