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Volumn 26, Issue 6, 2012, Pages 860-864

Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα

Author keywords

biochanin A; blood lipids; diabetes; formononetin; peroxisome proliferator activated receptor ; red clover extract

Indexed keywords

APOLIPOPROTEIN A5; APOLIPOPROTEIN C3; BIOCHANIN A; FORMONONETIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; RED CLOVER EXTRACT; STREPTOZOCIN; TRIACYLGLYCEROL;

EID: 84861810610     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3641     Document Type: Article
Times cited : (27)

References (30)
  • 1
    • 34547650833 scopus 로고    scopus 로고
    • Effects of dietary red clover on blood factors and cardiovascular fatty streak formation in hypercholesterolemic rabbits
    • Asgary S, Moshtaghian J, Naderi G, et al., 2007. Effects of dietary red clover on blood factors and cardiovascular fatty streak formation in hypercholesterolemic rabbits. Phytother Res 21: 768-770.
    • (2007) Phytother Res , vol.21 , pp. 768-770
    • Asgary, S.1    Moshtaghian, J.2    Naderi, G.3
  • 2
    • 0029759110 scopus 로고    scopus 로고
    • Transcriptional control of triglyceride metabolism: Fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR
    • Auwerx J, Schoonjans K, Fruchart JC, Staels B,. 1996. Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR. Atherosclerosis 124 (Suppl): S29-S37.
    • (1996) Atherosclerosis , vol.124 , Issue.SUPPL.
    • Auwerx, J.1    Schoonjans, K.2    Fruchart, J.C.3    Staels, B.4
  • 3
    • 18144411278 scopus 로고    scopus 로고
    • Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy?
    • Beck V, Rohr U, Jungbauer A,. 2005. Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy? J Steroid Biochem Mol Biol 94: 499-518.
    • (2005) J Steroid Biochem Mol Biol , vol.94 , pp. 499-518
    • Beck, V.1    Rohr, U.2    Jungbauer, A.3
  • 4
    • 0036895683 scopus 로고    scopus 로고
    • Beneficial role of dietary phytoestrogens in obesity and diabetes
    • Bhathena SJ, Velasquez MT,. 2002. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 76: 1191-1201.
    • (2002) Am J Clin Nutr , vol.76 , pp. 1191-1201
    • Bhathena, S.J.1    Velasquez, M.T.2
  • 5
    • 0037428403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein
    • Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Lowik CW,. 2003. Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein. J Biol Chem 278: 962-967.
    • (2003) J Biol Chem , vol.278 , pp. 962-967
    • Dang, Z.C.1    Audinot, V.2    Papapoulos, S.E.3    Boutin, J.A.4    Lowik, C.W.5
  • 6
    • 33645231124 scopus 로고    scopus 로고
    • A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects
    • Decochez K, Rippley RK, Miller JL, et al., 2006. A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects. Drugs R&D 7: 99-110.
    • (2006) Drugs R&D , vol.7 , pp. 99-110
    • Decochez, K.1    Rippley, R.K.2    Miller, J.L.3
  • 7
    • 0032530765 scopus 로고    scopus 로고
    • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice
    • Djouadi F, Weinheimer CJ, Saffitz JE, et al., 1998. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. J Clin Invest 102: 1083-1091.
    • (1998) J Clin Invest , vol.102 , pp. 1083-1091
    • Djouadi, F.1    Weinheimer, C.J.2    Saffitz, J.E.3
  • 8
    • 33746596198 scopus 로고    scopus 로고
    • Soy and red clover for mid-life and aging
    • Geller SE, Studee L,. 2006. Soy and red clover for mid-life and aging. Climacteric 9: 245-263.
    • (2006) Climacteric , vol.9 , pp. 245-263
    • Geller, S.E.1    Studee, L.2
  • 9
    • 33846028506 scopus 로고    scopus 로고
    • Effect of tesaglitazar, a dual PPAR alpha/gamma agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: A 12-week dose-ranging trial
    • Goldstein BJ, Rosenstock J, Anzalone D, Tou C, Ohman KP,. 2006. Effect of tesaglitazar, a dual PPAR alpha/gamma agonist, on glucose and lipid abnormalities in patients with type 2 diabetes: a 12-week dose-ranging trial. Curr Med Res Opin 22: 2575-2590.
    • (2006) Curr Med Res Opin , vol.22 , pp. 2575-2590
    • Goldstein, B.J.1    Rosenstock, J.2    Anzalone, D.3    Tou, C.4    Ohman, K.P.5
  • 10
    • 33646776061 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance
    • Guo L, Tabrizchi R,. 2006. Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance. Pharmacol Ther 111: 145-173.
    • (2006) Pharmacol Ther , vol.111 , pp. 145-173
    • Guo, L.1    Tabrizchi, R.2
  • 11
    • 33750634145 scopus 로고    scopus 로고
    • Comparison between phytoestrogens and estradiol in the prevention of atheroma in ovariectomized cholesterol-fed rabbits
    • Haines, C, James A, Sahota D, et al., 2006. Comparison between phytoestrogens and estradiol in the prevention of atheroma in ovariectomized cholesterol-fed rabbits. Climacteric 9: 430-436.
    • (2006) Climacteric , vol.9 , pp. 430-436
    • Haines, C.1    James, A.2    Sahota, D.3
  • 12
    • 0030841864 scopus 로고    scopus 로고
    • Modulation of tyrosine kinase activity has multiple actions on insulin release from the pancreatic beta-cell: Studies with lavendustin A
    • Hisatomi M, Hayakawa T, Hidaka H, Niki I,. 1997. Modulation of tyrosine kinase activity has multiple actions on insulin release from the pancreatic beta-cell: studies with lavendustin A. Jpn J Pharmacol 74: 203-208.
    • (1997) Jpn J Pharmacol , vol.74 , pp. 203-208
    • Hisatomi, M.1    Hayakawa, T.2    Hidaka, H.3    Niki, I.4
  • 13
    • 0034283535 scopus 로고    scopus 로고
    • The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia
    • Howes JB, Sullivan D, Lai N, et al., 2000. The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia. Atherosclerosis 152: 143-147.
    • (2000) Atherosclerosis , vol.152 , pp. 143-147
    • Howes, J.B.1    Sullivan, D.2    Lai, N.3
  • 14
  • 15
    • 85056042185 scopus 로고    scopus 로고
    • The effect of PPARgamma-agonism on LDL subclass profile in patients with type 2 diabetes and coronary artery disease
    • Lautamaki R, Nuutila P, Airaksinen KE, et al., 2006. The effect of PPARgamma-agonism on LDL subclass profile in patients with type 2 diabetes and coronary artery disease. Rev Diabet Stud 3: 31-38.
    • (2006) Rev Diabet Stud , vol.3 , pp. 31-38
    • Lautamaki, R.1    Nuutila, P.2    Airaksinen, K.E.3
  • 16
    • 33748065969 scopus 로고    scopus 로고
    • Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats
    • Lee JS,. 2006. Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sci 79: 1578-1584.
    • (2006) Life Sci , vol.79 , pp. 1578-1584
    • Lee, J.S.1
  • 17
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    • Lefebvre P, Chinetti G, Fruchart JC, Staels B,. 2006. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 116: 571-580.
    • (2006) J Clin Invest , vol.116 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.C.3    Staels, B.4
  • 18
    • 24744441935 scopus 로고    scopus 로고
    • Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: A pilot trial
    • Lukaczer D, Darland G, Tripp M, et al., 2005. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Altern Ther Health Med 11: 60-65.
    • (2005) Altern Ther Health Med , vol.11 , pp. 60-65
    • Lukaczer, D.1    Darland, G.2    Tripp, M.3
  • 19
    • 0037657668 scopus 로고    scopus 로고
    • Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells
    • Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N,. 2003. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 133: 1238-1243.
    • (2003) J Nutr , vol.133 , pp. 1238-1243
    • Mezei, O.1    Banz, W.J.2    Steger, R.W.3    Peluso, M.R.4    Winters, T.A.5    Shay, N.6
  • 20
    • 77949405407 scopus 로고    scopus 로고
    • Red clover extract: A source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages
    • Mueller M, Hobiger S, Jungbauer A,. 2010. Red clover extract: a source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages. Menopause 17: 379-387.
    • (2010) Menopause , vol.17 , pp. 379-387
    • Mueller, M.1    Hobiger, S.2    Jungbauer, A.3
  • 21
    • 0027134851 scopus 로고
    • Genistein augments cyclic adenosine 3'5'-monophosphate(cAMP) accumulation and insulin release in MIN6 cells
    • Ohno T, Kato N, Ishii C, et al., 1993. Genistein augments cyclic adenosine 3'5'-monophosphate(cAMP) accumulation and insulin release in MIN6 cells. Endocr Res 19: 273-285.
    • (1993) Endocr Res , vol.19 , pp. 273-285
    • Ohno, T.1    Kato, N.2    Ishii, C.3
  • 22
    • 47749155983 scopus 로고    scopus 로고
    • Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis
    • Qiu L, Wu X, Chau JF, et al., 2008. Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis. J Biol Chem 283: 17175-17183.
    • (2008) J Biol Chem , vol.283 , pp. 17175-17183
    • Qiu, L.1    Wu, X.2    Chau, J.F.3
  • 24
    • 33645512781 scopus 로고    scopus 로고
    • Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro
    • Shen P, Liu MH, Ng TY, Chan YH, Yong EL,. 2006. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. J Nutr 136: 899-905.
    • (2006) J Nutr , vol.136 , pp. 899-905
    • Shen, P.1    Liu, M.H.2    Ng, T.Y.3    Chan, Y.H.4    Yong, E.L.5
  • 25
    • 0028201430 scopus 로고
    • Effect of tyrosine kinase inhibitors on islets of Langerhans: Evidence for tyrosine kinases in the regulation of insulin secretion
    • Sorenson RL, Brelje TC, Roth C,. 1994. Effect of tyrosine kinase inhibitors on islets of Langerhans: evidence for tyrosine kinases in the regulation of insulin secretion. Endocrinology 134: 1975-1978.
    • (1994) Endocrinology , vol.134 , pp. 1975-1978
    • Sorenson, R.L.1    Brelje, T.C.2    Roth, C.3
  • 26
    • 34147144498 scopus 로고    scopus 로고
    • Soy isoflavones lower serum total and LDL cholesterol in humans: A meta-analysis of 11 randomized controlled trials
    • Taku, K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S,. 2007. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 85: 1148-1156.
    • (2007) Am J Clin Nutr , vol.85 , pp. 1148-1156
    • Taku, K.1    Umegaki, K.2    Sato, Y.3    Taki, Y.4    Endoh, K.5    Watanabe, S.6
  • 27
    • 0036548394 scopus 로고    scopus 로고
    • Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women: A four-week study
    • Uesugi T, Fukui Y, Yamori Y,. 2002. Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women: a four-week study. J Am Coll Nutr 21: 97-102.
    • (2002) J Am Coll Nutr , vol.21 , pp. 97-102
    • Uesugi, T.1    Fukui, Y.2    Yamori, Y.3
  • 28
    • 0032709304 scopus 로고    scopus 로고
    • Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE)
    • Vedavanam K, Srijayanta S, O'Reilly J, Raman A, Wiseman H,. 1999. Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). Phytother Res 13: 601-608.
    • (1999) Phytother Res , vol.13 , pp. 601-608
    • Vedavanam, K.1    Srijayanta, S.2    O'Reilly, J.3    Raman, A.4    Wiseman, H.5
  • 29
    • 0038043229 scopus 로고    scopus 로고
    • Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators
    • Vu-Dac N, Gervois P, Jakel H, et al., 2003. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J Biol Chem 278: 17982-17985.
    • (2003) J Biol Chem , vol.278 , pp. 17982-17985
    • Vu-Dac, N.1    Gervois, P.2    Jakel, H.3
  • 30
    • 0035145693 scopus 로고    scopus 로고
    • Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women
    • Wangen KE, Duncan AM, Xu X, Kurzer MS,. 2001. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73: 225-231.
    • (2001) Am J Clin Nutr , vol.73 , pp. 225-231
    • Wangen, K.E.1    Duncan, A.M.2    Xu, X.3    Kurzer, M.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.