Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: A pilot trial

Alternative Therapies in Health and Medicine

Volumn 11, Issue 5, 2005, Pages 60-65

  Lukaczer, Daniel ^a,b   Darland, Gary ^c   Tripp, Matthew ^c   Liska, DeAnn ^c   Lerman, Robert H ^a,d   Schiltz, Barbara ^a   Bland, Jeffrey S ^c,d  

^a Functional Medicine Research Center   (United States)

^b Metagenics Inc   (United States)

^c Metagenics ^*  (United States)

^d Institute for Functional Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA HYDROXYESTRONE; 2 HYDROXYESTRONE; 5 METHYLTETRAHYDROFOLIC ACID; ALPHA TOCOPHEROL; BETAINE; CALCIUM SILICATE; CHRYSIN; CROSCARMELLOSE SODIUM; CURCUMIN; CYANOCOBALAMIN; FOLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; ISOFLAVONE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PUERARIA LOBATA EXTRACT; PYRIDOXINE; RED CLOVER EXTRACT; RESVERATROL; RETINOL; ROSMARINUS OFFICINALIS EXTRACT; SILICON DIOXIDE; STEARIC ACID; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN K GROUP;

ADULT; ALTERNATIVE MEDICINE; ARTICLE; BREAST CANCER; CANCER RISK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HEART PROTECTION; HORMONE SUBSTITUTION; HOT FLUSH; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSAL SYNDROME; MENOPAUSE; NIGHT SWEAT; QUALITY OF LIFE; RED CLOVER;

ADULT; BREAST NEOPLASMS; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; FEMALE; FOOD HABITS; HOT FLASHES; HUMANS; ISOFLAVONES; MENOPAUSE; MIDDLE AGED; PHYTOESTROGENS; PHYTOTHERAPY; PILOT PROJECTS; PLANT EXTRACTS; QUALITY OF LIFE; QUESTIONNAIRES; TIME FACTORS; TREATMENT OUTCOME; TRIFOLIUM;

EID: 24744441935     PISSN: 10786791     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Notelovitz M. Estrogen replacement therapy: Indications, contraindications, and agent selection. Am J Obstet Gynecol. 1989;161:1832-1841.
2. Boulet MJ, Oddens BJ, Lehert P, Vemer HM, Visser A. Climacteric and menopause in seven South-east Asian countries. Maturitas. 1994;19:157-176.
3. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: Scientific review. JAMA. 2002;288:872-881.
4. Derby CA, Hume AL, Barbour MM, et al. Correlates of postmenopausal estrogen use and trends through the 1980s in two southeastern New England communities. Am J Epidemiol. 1993;137:1125-1135.
5. Brett KM, Madans JH. Use of postmenopausal hormone replacement therapy: estimates from a nationally representative cohort study. Am J Epidemiol. 1997;145:536-545.
6. Setchell KD. Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr. 2001;20(5 Suppl):354S-362S.
7. Murkies AL, Lombard C, Strauss BJ, et al. Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat. Maturitas. 1995;21:189-195.
8. Albertazzi P, Pansini F, Bonaccorsi G, et al. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol. 1998;91:6-11.
9. Erratum in: Obstet Gynecol. 2001;98:702.
10. Scambia G, Mango D, Signorile PG, et al. Clinical effects of a standardized soy extract in postmenopausal women: A pilot study. Menopause. 2000;7:105-111.
11. Albert A, Altabre C, Baro F, et al. Efficacy and safety of a phytoestrogen preparation derived from Glycine max (L.) Merr in climacteric symptomatology: A multicentric, open, prospective and non-randomized trial. Phytomedicine. 2002;9:85-92.
12. van de Weijer P, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas. 2002;42:187-193.
13. Van Patten CL, Olivotto IA, Chambers GK, et al. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: A randomized, controlled clinical trial. J Clin Oncol. 2002;20:1449-1455.
14. Upmalis DH, Lobo R, Bradley L, et al. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: A multicenter, double-blind, randomized, placebo-controlled study. Menopause. 2000;7:236-242.
15. Erratum in: Menopause. 2000;7:422.
16. Quella SK, Loprinzi CL, Barton DL, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol. 2000;18:1068-1074.
17. Knight DC, Howes JB, Eden JA. The effect of Promensil, an isoflavone extract, on menopausal symptoms. Climacteric. 1999;2:79-84.
18. Baber RJ, Templeman C, Morton T, Kelly GE, West L. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric. 1999;2:85-92.
19. Schneider HP. The quality of life in the post-menopausal woman. Best Pract Res Clin Obstet Gynaecol. 2002;16:395-409.
20. Muti P, Bradlow HL, Micheli A, et al. Estrogen metabolism and risk of breast cancer: A prospective study of the 2:16alpha-hydroxyestrone ratio in premenopausal and postmenopausal women. Epidemiology. 2000;11:635-640.
21. Meilahn EN, De Stavola B, Allen DS, et al. Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. Br J Cancer. 1998;78:1250-1255.
22. Castagnetta LA, Carruba G. Re: Urinary 2-hydroxyestrone/16alpha- hydroxyestrone ratio and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 1999;91:1893-1894.
23. Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot flushes in early postmenopausal women : a randomized, double-blind EPT-and placebo-controlled study. Menopause. 2004;11:400-404.
24. Jacobson JS, Grann VR. Can an herbal agent replace estrogen for hot flashes? Cancer Invest. 2004;22:645-647.
25. Pockaj BA, Loprinzi CL, Sloan JA, et al. Pilot evaluation of black cohosh for the treatment of hot flashes in women. Cancer Invest. 2004;22:515-521.
26. Nestel PJ, Pomeroy S, Kay S, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab. 1999;84:895-898.
27. Erratum in: J Clin Endocrinol Metab. 1999;84:3647.
28. Clarke R, Armitage J. Vitamin supplements and cardiovascular risk: review of the randomized trials of HCys-lowering vitamin supplements. Semin Thromb Hemost. 2000;26:341-348.
29. Goodman JE, Lavigne JA, Wu K, et al. COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk. Carcinogenesis. 2001;22:1661-1665.
30. 12 deficiency: a new risk factor for breast cancer? Nutr Rev. 1999;57:250-260.
31. Huange C-S, Chern H-D, Change K-J, et al. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res. 1999;59:4870-4875.
32. Wu K, Helzlsouer KJ, Comstock GW, et al. A prospective study on folate, B12, and pyridoxat 5′-phosphate (B6) and breast cancer. Cancer Epidemiol Biomarkers Prev. 1999;8:209-217.
33. Kabat GC, Chang CJ, Sparano JA, et al. Urinary estrogen metabolites and breast cancer: A case-control study. Cancer Epidemiol Biomarkers Prev. 1997;6:505-509.
34. Ursin G, London S, Stanczyk FZ, et al. Urinary 2-hydroxyestrone/16alpha- hydroxyestrone ratio and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 1999;91:1067-1072.
35. Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. 1998;7:1101-1108.
36. Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2000;9:781-786.
37. Guerra MC, Speroni E, Broccoli M, et al. Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. Life Sci. 2000;67:2997-3006.
38. Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998;19:1821-1827.