Statin pleiotropy prevents rho kinase-mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteases

Cellular Microbiology

Volumn 14, Issue 9, 2012, Pages 1474-1484

  Mirza, Haris ^a   Wu, Zhaona ^b   Teo, Joshua D W ^b   Tan, Kevin S W ^b  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CYSTEINE PROTEINASE; F ACTIN; FASUDIL; FLUORESCEIN ISOTHIOCYANATE; METRONIDAZOLE; MYOSIN LIGHT CHAIN; PROTEIN ZO1; RHO KINASE; SIMVASTATIN;

ACTIN FILAMENT; ANTIBIOTIC RESISTANCE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BLASTOCYSTIS; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; MEMBRANE DAMAGE; MEMBRANE RESISTANCE; MONOLAYER CULTURE; NONHUMAN; PERMEABILITY BARRIER; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

BLASTOCYSTIS; CACO-2 CELLS; CYSTEINE PROTEASES; CYTOSKELETON; HUMANS; INTESTINAL MUCOSA; PERMEABILITY; RHO-ASSOCIATED KINASES; SIMVASTATIN; VIRULENCE FACTORS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84865335552     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2012.01814.x     Document Type: Article

References (47)

1. Andersson, M., Löw, P., and Bakhiet, M. (1996) Lovastatin inhibits interferon-gamma-induced Trypanosoma brucei brucei proliferation: evidence for mevalonate pathway involvement. J Interferon Cytokine Res 16: 435-439.
2. Chandramathi, S., Suresh, K., and Kuppusamy, U.R. (2010) Solubilized antigen of Blastocystis hominis facilitates the growth of human colorectal cancer cells, HCT116. Parasitol Res 106: 941-945.
3. Chen, W., Pendyala, S., Natarajan, V., Garcia, J.G., and Jacobson, J.R. (2008) Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition. Am J Physiol Lung Cell Mol Physiol 295: L575-L583.
4. Dagci, H., Ustun, S., Taner, M.S., Ersoz, G., Karacasu, F., and Budak, S. (2002) Protozoon infections and intestinal permeability. Acta Trop 81: 1-5.
5. Epple, H.J., Schneider, T., Troeger, H., Kunkel, D., Allers, K., Moos, V., etal. (2009) Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58: 220-227.
6. Gavard, J., and Gutkind, J.S. (2008) Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. J Biol Chem 283: 29888-29896.
7. Groeger, S., Doman, E., Chakraborty, T., and Meyle, J. (2010) Effects of Porphyromonas gingivalis infection on human gingival epithelial barrier function in vitro Eur J Oral Sci 118: 582-589.
8. Khan, N.A., and Siddiqui, R. (2009) Acanthamoeba affects the integrity of human brain microvascular endothelial cells and degrades the tight junction proteins. Int J Parasitol 39: 1611-1616.
9. Kosako, H., Yoshida, T., Matsumura, F., Ishizaki, T., Narumiya, S., and Inagaki, M. (2000) Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene 19: 6059-6064.
10. Kurniawan, A., Karyadi, T., Dwintasari, S.W., Sari, I.P., Yunihastuti, E., Djauzi, S., and Smith, H.V. (2009) Intestinal parasitic infections in HIV/AIDS patients presenting with diarrhoea in Jakarta, Indonesia. Trans R Soc Trop Med Hyg 103: 892-898.
11. Lapointe, T.K., O'Connor, P.M., Jones, N.L., Menard, D., and Buret, A.G. (2010) Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection. Cell Microbiol 12: 692-703.
12. Lauwaet, T., Oliveira, M.J., Callewaert, B., De Bruyne, G., Mareel, M., and Leroy, A. (2004) Proteinase inhibitors TPCK and TLCK prevent Entamoeba histolytica induced disturbance of tight junctions and microvilli in enteric cell layers in vitro Int J Parasitol 34: 785-794.
13. Li, E., Stenson, W.F., Kunz-Jenkins, C., Swanson, P.E., Duncan, R., and Stanley, S.L. (1994) Entamoeba histolytica interactions with polarized human intestinal Caco-2 epithelial cells. Infect Immun 62: 5112-5119.
14. Mirza, H., and Tan, K.S. (2009) Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity. Parasitol Res 104: 355-361.
15. Mirza, H., Teo, J.D., Upcroft, J., and Tan, K.S. (2011) A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities. Antimicrob Agents Chemother 55: 637-648.
16. Noël, C., Dufernez, F., Gerbod, D., Edgcomb, V.P., Delgado-Viscogliosi, P., Ho, L.C., etal. (2005) Molecular phylogenies of Blastocystis isolates from different hosts: implications for genetic diversity, identification of species, and zoonosis. J Clin Microbiol 43: 348-355.
17. Nohria, A., Prsic, A., Liu, P.Y., Okamoto, R., Creager, M.A., Selwyn, A., etal. (2009) Statins inhibit Rho kinase activity in patients with atherosclerosis. Atherosclerosis 205: 517-521.
18. Noureldin, M.S., Shaltout, A.A., El Hamshary, E.M., and Ali, M.E. (1999) Opportunistic intestinal protozoal infections in immunocompromised children. J Egypt Soc Parasitol 29: 951-961.
19. Parquet, V., Henry, M., Wurtz, N., Dormoi, J., Briolant, S., Gil, M., etal. (2010) Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum Malar J 9: 139.
20. Puthia, M.K., Vaithilingam, A., Lu, J., and Tan, K. (2005) Degradation of human secretory immunoglobulin A by Blastocystis Parasitol Res 97: 386-389.
21. Puthia, M.K., Sio, S.W., Lu, J., and Tan, K.S. (2006a) Blastocystis ratti induces contact-independent apoptosis, F-actin rearrangement, and barrier function disruption in IEC-6 cells. Infect Immun 74: 4114-4123.
22. Puthia, M.K., Sio, S., Lu, J., and Tan, K. (2006b) Blastocystis ratti induces contact-independent apoptosis, F-actin rearrangement, and barrier function disruption in IEC-6 cells. Infect Immun 74: 4114-4123.
23. Puthia, M.K., Lu, J., and Tan, K.S. (2008a) Blastocystis ratti contains cysteine proteases that mediate interleukin-8 response from human intestinal epithelial cells in an NF-kappaB-dependent manner. Eukaryot Cell 7: 435-443.
24. Puthia, M.K., Lu, J., and Tan, K. (2008b) Blastocystis ratti contains cysteine proteases that mediate interleukin-8 response from human intestinal epithelial cells in an NF-kappaB-dependent manner. Eukaryot Cell 7: 435-443.
25. Reed, C.E., and Kita, H. (2004) The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 114: 997-1008, quiz 1009.
26. Riento, K., and Ridley, A.J. (2003) Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4: 446-456.
27. Rodríguez, C., Alcudia, J.F., Martínez-González, J., Guadall, A., Raposo, B., Sánchez-Gómez, S., and Badimon, L. (2009) Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. Cardiovasc Res 83: 595-603.
28. Sarkar, K., Sinha, A.K., and Mehta, J.L. (2006) The role of statins in endothelial dysfunction in hypertension. Curr Opin Cardiol 21: 316-321.
29. Scott, K.G., Meddings, J.B., Kirk, D.R., Lees-Miller, S.P., and Buret, A.G. (2002) Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology 123: 1179-1190.
30. Shibuya, M., Suzuki, Y., Sugita, K., Saito, I., Sasaki, T., Takakura, K., etal. (1992) Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg 76: 571-577.
31. Sio, S., Puthia, M., Lee, A., Lu, J., and Tan, K. (2006) Protease activity of Blastocystis hominis Parasitol Res 99: 126-130.
32. Soliman, M.F., and Ibrahim, M.M. (2005) Antischistosomal action of atorvastatin alone and concurrently with medroxyprogesterone acetate on Schistosoma haematobium harboured in hamster: surface ultrastructure and parasitological study. Acta Trop 93: 1-9.
33. Stensvold, C.R., Suresh, G.K., Tan, K.S., Thompson, R.C., Traub, R.J., Viscogliosi, E., etal. (2007) Terminology for Blastocystis subtypes-a consensus. Trends Parasitol 23: 93-96.
34. Stensvold, C.R., Lewis, H.C., Hammerum, A.M., Porsbo, L.J., Nielsen, S.S., Olsen, K.E., etal. (2009) Blastocystis: unravelling potential risk factors and clinical significance of a common but neglected parasite. Epidemiol Infect 137: 1655-1663.
35. Stensvold, C.R., Smith, H.V., Nagel, R., Olsen, K.E., and Traub, R.J. (2010) Eradication of Blastocystis carriage with antimicrobials: reality or delusion? J Clin Gastroenterol 44: 85-90.
36. Tan, K.S. (2008) New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev 21: 639-665.
37. Tan, K.S., Mirza, H., Teo, J.D., Wu, B., and Macary, P.A. (2010) Current views on the clinical relevance of Blastocystis spp. Curr Infect Dis Rep 12: 28-35.
38. Taoufiq, Z., Gay, F., Balvanyos, J., Ciceron, L., Tefit, M., Lechat, P., and Mazier, D. (2008) Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia. J Infect Dis 197: 1062-1073.
39. Taşova, Y., Sahin, B., Koltaş, S., and Paydaş, S. (2000) Clinical significance and frequency of Blastocystis hominis in Turkish patients with hematological malignancy. Acta Med Okayama 54: 133-136.
40. Turner, J.R. (2009) Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9: 799-809.
41. Valsecchi, R., Leghissa, P., and Greco, V. (2004) Cutaneous lesions in Blastocystis hominis infection. Acta Derm Venereol 84: 322-323.
42. Van Itallie, C.M., Fanning, A.S., Bridges, A., and Anderson, J.M. (2009) ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell 20: 3930-3940.
43. Vogelberg, C., Stensvold, C.R., Monecke, S., Ditzen, A., Stopsack, K., Heinrich-Gräfe, U., and Pöhlmann, C. (2010) Blastocystis sp. subtype 2 detection during recurrence of gastrointestinal and urticarial symptoms. Parasitol Int 59: 469-471.
44. Wan, H., Winton, H.L., Soeller, C., Tovey, E.R., Gruenert, D.C., Thompson, P.J., etal. (1999) Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 104: 123-133.
45. Wang, C.Y., Liu, P.Y., and Liao, J.K. (2008) Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med 14: 37-44.
46. Wong, K., Ng, G., Lin, R., Yoshikawa, H., Taylor, M., and Tan, K. (2008) Predominance of subtype 3 among Blastocystis isolates from a major hospital in Singapore. Parasitol Res 102: 663-670.
47. Zhou, Q., and Liao, J.K. (2009) Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy. Curr Pharm Des 15: 467-478.