Lovastatin inhibits interferon-γ-induced Trypanosoma brucei brucei proliferation: Evidence for mevalonate pathway involvement

Journal of Interferon and Cytokine Research

Volumn 16, Issue 6, 1996, Pages 435-439

  Bakhiet, Moiz ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MEVALONIC ACID; MEVINOLIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; DRUG INHIBITION; ENZYME ACTIVITY; GROWTH STIMULATION; IMMUNOREGULATION; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE INDUCTION; TRYPANOSOMA BRUCEI;

ANIMALIA; TRITIUM; TRIXIS; TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0029889979     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.435     Document Type: Article

References (4)

1. + T cells: A trypanosome-released factor triggers interferon-IFN-γ production that stimulates parasite growth. Eur. J. Immunol. 21, 2447-2454.
2. OLSSON, T., BAKHIET, M., HÖJEBERG, B., LJUNGDAHL, Å., EDLUND, C., ANDERSSON, G., EKRE, H.P., FUNG LEUNG, W.P., MAK, T., WIGZELL, H., FISZER, U., and KRISTENSSON, K. (1993). CD8 is critically involved in lymphocyte activation by a T. b. brucei released molecule. Cell 72, 715-727.
3. BAKHIET, M., OLSSON, T., EDLUND, C., HÖJEBERG, B., HOLMBERG, K., LORENTZEN, J., and KRISTENSSON, K. (1993). A Trypanosoma brucei brucei derived factor that triggers CD8+ lymphocytes to IFN-γ secretion: Purification, characterization and protective effects in vivo by treatment with a monoclonal antibody against the factor. Scand. J. Immunol. 37, 165-178.
4. HIDE, G., GRAY, A., HARRISON. C.M., and TAIT, A. (1989). Identification of an epidermal growth factor receptor homologue in trypanosomes. Mol. Biochem. Parasitol. 36, 51-60.