Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway

Cellular Signalling

Volumn 24, Issue 11, 2012, Pages 2024-2034

  Funakoshi Tago, Megumi ^a   Nagata, Tatsuaki ^a   Tago, Kenji ^b   Tsukada, Masaki ^a   Tanaka, Kazuyuki ^a   Nakamura, Shigeo ^c   Mashino, Tadahiko ^a   Kasahara, Tadashi ^a  

^a KEIO UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; Apoptosis signal regulating kinase 1 (ASK1); C Jun N terminal kinase (JNK); Fullerene; JAK2 V617F mutation; Myeloproliferative neoplasms (MPNs)

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS SIGNAL REGULATING KINASE 1; FULLERENE BIS(N,N DIMETHYLPYRROLIDINIUM IODIDE); FULLERENE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MYC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME INHIBITION; MOUSE; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTHRACENES; APOPTOSIS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; FULLERENES; JANUS KINASE 2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE KINASE 7; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; MICE; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

MUS MUSCULUS;

EID: 84865334665     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.06.014     Document Type: Article

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