SERPINB3 expression on B-cell surface in autoimmune diseases and hepatitis C virus-related chronic liver infection

Experimental Biology and Medicine

Volumn 237, Issue 7, 2012, Pages 793-802

  Vidalino, Laura ^a   Doria, Andrea ^a   Quarta, Santina M ^a   Crescenzi, Marika ^a   Ruvoletto, Mariagrazia ^a   Frezzato, Federica ^a   Trentin, Livio ^a   Turato, Cristian ^b   Parolin, Maria Cristina ^a   Ghirardello, Anna ^a   Iaccarino, Luca ^a   Cavalletto, Luisa ^a   Chemello, Liliana ^a   Gatta, Angelo ^a   Pontisso, Patrizia ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

HCV infection; SERPINB3; Serpins; Systemic lupus erythematosus

Indexed keywords

CD27 ANTIGEN; CD69 ANTIGEN; CD71 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; PEGINTERFERON ALPHA; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR B3; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CELL SURFACE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ANTIGENS, NEOPLASM; B-LYMPHOCYTES; BASE SEQUENCE; CASE-CONTROL STUDIES; DNA PRIMERS; FEMALE; FLOW CYTOMETRY; HEPATITIS C, CHRONIC; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERPINS;

EID: 84865312290     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.012024     Document Type: Article

References (52)

1. Gettins PG. Serpin structure, mechanism, and function. Chem Rev 2002;102:4751-804
2. Kato H. Expression and function of squamous cell carcinoma antigen. Anticancer Res 1996;16:2149-53
3. Kato H, Suehiro Y, Morioka H, Torigoe T, Myoga A, Sekiguchi K, Ikeda I. Heterogeneous distribution of acidic TA-4 in cervical squamous cell carcinoma: immunohistochemical demonstration with monoclonal antibodies. Jp J Cancer Res 1987;78:1246-50
4. Pontisso P, Calabrese F, Benvegnù L, Lise M, Belluco C, Ruvoletto MG, Marino M, Valente M, Nitti D, Gatta A, Fassina G. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. Br J Cancer 2004;90:833-7
5. Giannelli G, Marinosci F, Sgarra C, Lupo L, Dentico P, Antonaci S. Clinical role of tissue and serum levels of SCCA antigen in hepatocellular carcinoma. Int J Cancer 2005;116:579-83
6. De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G. Cloning and expression of a novel hepatitis B virus binding protein from HepG 2 cells. J Biol Chem 2001;276:36613-23
7. Moore PL, Ong S, Harrison TJ. Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system. J Biol Chem 2003;278:46709-17
8. Pontisso P, Morsica G, Ruvoletto MG, Zambello R, Colletta C, Chemello L, Alberti A. Hepatitis B virus binds to peripheral blood mononuclear cells via the pre S1 protein. J Hepatol 1991;12:203-26
9. Pontisso P, Vidalino L, Quarta S, Gatta A. Biological and clinical implications of HBV infection in peripheral blood mononuclear cells. Autoimmun Rev 2008;8:13-7
10. Ruvoletto MG, Tono N, Carollo D, Vilei T, Trentin L, Muraca M, Marino M, Gatta A, Fassina G, Pontisso P. Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. J Gen Virol 2004;85:621-4
11. Uemura Y, Pak SC, Luke C, Cataltepe S, Tsu C, Schick C, Kamachi Y, Pomeroy SL, Perlmutter DH, Silverman GA. Circulating serpin tumor markers SCCA and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Int J Cancer 2000;89:368-77
12. Izuhara K, Ohta S, Kanaji S, Shiraishi H, Arima K. Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family. Cell Mol Life Sci 2008;65:2541-53
13. Suminami Y, Nagashima S, Vujanovic NL, Hirabayashi K, Kato H, Whiteside TL. Inhibition of apoptosis in human tumor cells by tumor-associated serpin, SCC antigen. Br J Cancer 2000;82:981-9
14. Suminami Y, Nagashima S, Murakami A, Nawata S, Gondo T, Hirakawa H. Suppression of squamous cell carcinoma antogen (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased infiltration of natural killer cells. Cancer Res 2001;61:1776-80
15. Vidalino L, Doria A, Quarta S, Zen M, Gatta A, Pontisso P. SERPINB3, apoptosis and autoimmunity. Autoimmun Rev 2009;9:108-12
16. Hashimoto K, Kiyoshima T, Matsuo K, Ozeki S, Sakai H. Effect of SCCA1 and SCCA2 on the suppression of TNF-alpha-induced cell death by impeding the release of mitochondrial cytochrome c in an oral squamous cell carcinoma cell line. Tumour Biol 2005;26:165-72
17. Barazani Y, Hiatt JR, Tong MJ, Busuttil RW. Chronic viral hepatitis and hepatocellular carcinoma. World J Surg 2007;31:1245-50
18. Spengler U, Nattermann J. Immunopathogenesis in hepatitis C virus cirrhosis. Clin Science 2007;112:141-55
19. Kanto T, Hayashi N. Immunopathogenesis of hepatitis C virus infection: multifaceted strategies subverting innate and adaptive immunity. Intern Med 2006;45:183-91
20. Neumann-Haefelin C, Blum HE, Chisari FV, Thimme R. T cell response in hepatitis C virus infection. J Clin Virol 2005;32:75-85
21. Agematsu K, Nagumo H, Yang FC, Nakazawa T, Fukushima K, Ito S, Sugita K, Mori T, Kobata T, Morimoto C, Komiyama A. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol 1997;27:2073-9
22. Mondelli MU. Multifaceted functions of B cells in chronic hepatitis C virus infection. Antiviral Res 2003;60:111-5
23. Stamanataki Z, Shannon-Lowe C, Shaw J, Mutimer D, Rickinson AB, Gordon J, Adams DH, Balfe P, McKeating JA. Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver derived hepatoma cells. Blood 2009;113:585-93
24. Anolik J, Sanz I. B cells in human and murine systemic lupus erythematosus. Curr Opin Rheumatol 2004;16:505-12
25. Gualtierotti R, Biggioggero M, Penatti AE, Meroni PL. Updating on the pathogenesis of systemic lupus erythematosus. Autoimmun Rev 2010;10:3-7
26. Doria A, Sarzi-Puttini P, Shoenfeld Y. Infections, rheumatism and autoimmunity: the conflicting relationship between humans and their environment. Autoimmun Rev 2008;8:1-4
27. Doria A, Canova M, Tonon M, Zen M, Rampudda E, Bassi N, Atzeni F, Zampieri S, Ghirardello A. Infections as triggers and complications of systemic lupus erythematosus. Autoimmun Rev 2008;8:24-8
28. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725
29. Bencivelli W, Vitali C, Isenberg DA, Smolen JS, Snaith ML, Sciuto M, Bombardieri S. Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. III. Development of a computerised clinical chart and its application to the comparison of different indices of disease activity. The European Consensus Study Group for Disease Activity in SLE. Clin Exp Rheumatol 1992;10:549-54
30. Quarta S, Vidalino L, Turato C, Ruvoletto M, Calabrese F, Valente M, Cannito S, Fassina G, Parola M, Gatta A, Pontisso P. SERPINB3 induces epithelial-mesenchymal transition. J Pathol 2010;221:343-56
31. Crotta S, Stilla A, Wack A, D'Andrea A, Nuti S, D'Oro U, Mosca M, Filliponi F, Brunetto RM, Bonino F, Abrignani S, Valiante NM. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med 2002;195:35-41
32. Tseng CT, Klimpel GR. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med 2002;195:43-9
33. Forns X, Bruix J. Treating hepatitis C in patients with cirrhosis: the effort is worth it. J Hepatol 2010;52:624-6
34. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 2009;16:295-308
35. Patzwahl R, Meier V, Ramadori G, Mihm S. Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridization. J Virol 2001;75:1332-8
36. Scagnolari C, Bellomi F, Trombetti S, Casato M, Carlesimo M, Bagnato F, Lavolpe V, Bruno R, Millefiorini E, Antonelli L, Girardi E Turriziani O, Antonelli G. Expression of biomarkers of interferon type I in patients suffering from chronic diseases. Clin Exp Immunol 2007;147:270-6
37. Qu L, Lemon SM. Hepatitis A and hepatitis C viruses: divergent infection outcomes marked by similarities in induction and evasion of interferon responses. Semin Liver Dis 2010;30:319-32
38. Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology 2003;38:4-13
39. Sansonno D, De Vita S, Iacobelli AR, Cornacchiulo V, Boiocchi M, Dammacco F. Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia. J Immunol 1998;160:3594
40. Schulze C, Munoz LE, Franz S, Sarter K, Chaurio RA, Gaipl US, Herrmann M. Clearance deficiency-a potential link between infections and autoimmunity. Autoimmun Rev 2008;8:5-8
41. Janko C, Schorn C, Grossmayer GE, Frey B, Herrmann M, Gaipl US, Munoz LE. Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). Autoimmun Rev 2008;8:9-12
42. Navratil JS, Liu CC, Ahearn JM. Apoptosis and autoimmunity. Immunol Res 2006;8:1-4
43. Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, Pascual V. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003;17:711-23
44. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nature Rev Immunol 2003;6:23-835
45. Rama M, Anaya JM, Barzilai O, Izhaky D, Katz BP, Blank M, Shoenfeld Y. The putative protective role of hepatitis B virus (HBV) infection from autoimmune disorders. Autoimmun Rev 2008;7:621-5
46. Tangye SG, Liu YJ, Aversa G, Phillips JH, De Vries JE. Identification of functional splenic memory B cells by expression of CD148 and CD27. J Exp Med 1998;188:1691-703
47. Roque-Afonso AM, Ducoulombier D, Di Liberto G, Kara R, Gigou M, Dussaix E, Samuel D, Féray C. Compartimentalization of hepatitis C genotypes between plasma and peripheral blood mononucelar cells. J Virol 2005;79:6349-57
48. Racanelli V, Frassanito MA, Leone P, Galiano M, De Re V, Silvestris F, Dammacco F. Antibody production and in vitro behaviour of CD27-defined C-cell subsets: persistent hepatitis C virus infection changes the rules. J Virol 2006;80:3923-34
49. Ni J, Hembrador E, Di Bisceglie AM, Jacobson IM, Talal AH, Butera D, Rice CM, Chambers TJ, Dustin LB. Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients. J Immunol 2003;170:3429-39
50. Jenks SA, Sanz I. Altered B cell receptor signalling in human systemic lupus erythematosus. Autoimmun Rev 2009;8:209-13
51. Rodrìguez-Bayona B, Ramos-Amaya A, Prez-Venegas JJ, Rodrìguez C, Brieva JA. Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients. Arthritis Res Ther 2010;12:R108
52. Shapira E, Proscura E, Brodsky B, Wormser U. Novel peptides as potential treatment of systemic lupus erythematosus. Lupus 2011;20:463-72