The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Manceau, Valérie ^a,b   Kremmer, Elisabeth ^c   Nabel, Elizabeth G ^d   Maucuer, Alexandre ^a,b  

^a INSTITUT DU FER À MOULIN   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; CYSTEINE LOOP LIGAND GATED ION CHANNEL RECEPTOR; MESSENGER RNA; PROTEIN KINASE; PROTEIN KINASE KIS; PROTEIN SF1; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN METABOLISM; CONDITIONING; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEAR; FEMALE; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; MALE; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RNA SPLICING; TISSUE SPECIFICITY; WILD TYPE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CONDITIONING (PSYCHOLOGY); FEAR; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPERKINESIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MOTOR ACTIVITY; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 84865304556     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043946     Document Type: Article

References (42)

1. Qiu Z, Ghosh A, (2008) A brief history of neuronal gene expression: regulatory mechanisms and cellular consequences. Neuron 60: 449-455.
2. Li Q, Lee JA, Black DL, (2007) Neuronal regulation of alternative pre-mRNA splicing. Nat Rev Neurosci 8: 819-831.
3. Manceau V, Swenson M, Le Caer JP, Sobel A, Kielkopf CL, et al. (2006) Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65. FEBS J 273: 577-587.
4. Kramer A, (1992) Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex. Mol Cell Biol 12: 4545-4552.
5. Kramer A, Utans U, (1991) Three protein factors (SF1, SF3 and U2AF) function in pre-splicing complex formation in addition to snRNPs. Embo J 10: 1503-1509.
6. Abovich N, Rosbash M, (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89: 403-412.
7. Berglund JA, Abovich N, Rosbash M, (1998) A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Genes Dev 12: 858-867.
8. Berglund JA, Chua K, Abovich N, Reed R, Rosbash M, (1997) The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell 89: 781-787.
9. Kent OA, Reayi A, Foong L, Chilibeck KA, MacMillan AM, (2003) Structuring of the 3′ splice site by U2AF65. J Biol Chem 278: 50572-50577.
10. Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, et al. (2003) Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. Mol Cell 11: 965-976.
11. Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, et al. (2002) A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. Embo J 21: 3390-3401.
12. Maucuer A, Camonis JH, Sobel A, (1995) Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A 92: 3100-3104.
13. Caldwell BD, Darlington DN, Penzes P, Johnson RC, Eipper BA, et al. (1999) The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem 274: 34646-34656.
14. Langenickel TH, Olive M, Boehm M, San H, Crook MF, et al. (2008) KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. J Clin Invest 118: 3848-3859.
15. Bieche I, Manceau V, Curmi PA, Laurendeau I, Lachkar S, et al. (2003) Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Brain Res Mol Brain Res 114: 55-64.
16. Cambray S, Pedraza N, Rafel M, Gari E, Aldea M, et al. (2009) Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol 29: 726-735.
17. Maucuer A, Ozon S, Manceau V, Gavet O, Lawler S, et al. (1997) KIS is a protein kinase with an RNA recognition motif. J Biol Chem 272: 23151-23156.
18. Arning S, Gruter P, Bilbe G, Kramer A, (1996) Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. Rna 2: 794-810.
19. Thomas PD, Kejariwal A, Campbell MJ, Mi H, Diemer K, et al. (2003) PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res 31: 334-341.
20. Puri V, McQuillin A, Choudhury K, Datta S, Pimm J, et al. (2007) Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene. Biol Psychiatry 61: 873-879.
21. Puri V, McQuillin A, Datta S, Choudhury K, Pimm J, et al. (2008) Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. Eur J Hum Genet.
22. Powell SB, Zhou X, Geyer MA, (2009) Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res 204: 282-294.
23. Valjent E, Corbille AG, Bertran-Gonzalez J, Herve D, Girault JA, (2006) Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference. Proc Natl Acad Sci U S A 103: 2932-2937.
24. Kielkopf CL, Lucke S, Green MR, (2004) U2AF homology motifs: protein recognition in the RRM world. Genes Dev 18: 1513-1526.
25. Manceau V, Kielkopf CL, Sobel A, Maucuer A, (2008) Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. J Mol Biol 381: 748-762.
26. Guth S, Valcarcel J, (2000) Kinetic role for mammalian SF1/BBP in spliceosome assembly and function after polypyrimidine tract recognition by U2AF. J Biol Chem 275: 38059-38066.
27. Tanackovic G, Kramer A, (2005) Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo. Mol Biol Cell 16: 1366-1377.
28. Zhu R, Heaney J, Nadeau JH, Ali S, Matin A, (2010) Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res 70: 7264-7272.
29. Mazroui R, Puoti A, Kramer A, (1999) Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability. Rna 5: 1615-1631.
30. Shitashige M, Satow R, Honda K, Ono M, Hirohashi S, et al. (2007) Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis. Cancer Sci 98: 1862-1867.
31. Joyce CJ, (2007) In silico comparative genomic analysis of GABAA receptor transcriptional regulation. BMC Genomics 8: 203.
32. Steiger JL, Russek SJ, (2004) GABAA receptors: building the bridge between subunit mRNAs, their promoters, and cognate transcription factors. Pharmacol Ther 101: 259-281.
33. Alexander R, Beggs JD, (2010) Cross-talk in transcription, splicing and chromatin: who makes the first call? Biochem Soc Trans 38: 1251-1256.
34. Rutz B, Seraphin B, (2000) A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing. EMBO J 19: 1873-1886.
35. Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, et al. (2009) Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 54: 98-107.
36. Dumaine A, Maucuer A, Barbet A, Manceau V, Deshommes J, et al. (2011) Genetic and molecular exploration of UHMK1 in schizophrenic patients. Psychiatr Genet 21: 315-318.
37. Bristow GC, Lane TA, Walker M, Chen L, Sei Y, et al. (2009) Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. Brain Res 1301: 197-206.
38. Meijering E, Jacob M, Sarria JC, Steiner P, Hirling H, et al. (2004) Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry A 58: 167-176.
39. Begou M, Volle J, Bertrand JB, Brun P, Job D, et al. (2008) The stop null mice model for schizophrenia displays [corrected] cognitive and social deficits partly alleviated by neuroleptics. Neuroscience 157: 29-39.
40. Spooren W, Mombereau C, Maco M, Gill R, Kemp JA, et al. (2004) Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition. Psychopharmacology (Berl) 175: 99-105.
41. Ferguson RE, Carroll HP, Harris A, Maher ER, Selby PJ, et al. (2005) Housekeeping proteins: a preliminary study illustrating some limitations as useful references in protein expression studies. Proteomics 5: 566-571.
42. Gozani O, Potashkin J, Reed R, (1998) A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Mol Cell Biol 18: 4752-4760.