Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human

Molecular Brain Research

Volumn 114, Issue 1, 2003, Pages 55-64

  Bièche, Ivan ^b,c   Manceau, Valérie ^a   Curmi, Patrick A ^a   Laurendeau, Ingrid ^b   Lachkar, Sylvie ^a   Leroy, Karen ^d   Vidaud, Dominique ^b   Sobel, André ^a   Maucuer, Alexandre ^a  

^a INSTITUT DU FER À MOULIN   (France)

^b FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^c CENTRE RENÉ HUGUENIN   (France)

^d HENRI MONDOR HOSPITAL   (France)

Author keywords

Kinase KIS; Neurofibromatosis type 1; p27Kip1; Protein kinase; RNA recognition motif

Indexed keywords

ISOPROTEIN; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN SERINE KINASE; THREONINE;

ADULT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN NERVE CELL; BRAIN STEM; BRAIN TUMOR; CELL NUCLEUS; EMBRYO; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA;

EID: 0038356893     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(03)00132-3     Document Type: Article

References (29)

1. Ars E., Serra E., Garcia J., Kruyer H., Gaona A., Lazaro C., Estivill X. Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1. Hum. Mol. Genet. 9:2000;237-247.
2. Bieche I., Onody P., Laurendeau I., Olivi M., Vidaud D., Lidereau R., Vidaud M. Real-time reverse transcription-PCR assay for future management of ERBB2-based clinical applications. Clin. Chem. 45:1999;1148-1156.
3. Bieche I., Nogues C., Paradis V., Olivi M., Bedossa P., Lidereau R., Vidaud M. Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay. Clin. Cancer Res. 6:2000;452-459.
4. Birney E., Kumar S., Krainer A.R. Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res. 21:1993;5803-5816.
5. Boehm M., Yoshimoto T., Crook M.F., Nallamshetty S., True A., Nabel G.J., Nabel E.G. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 21:2002;3390-3401.
6. Caldwell B.D., Darlington D.N., Penzes P., Johnson R.C., Eipper B.A., Mains R.E. The novel kinase peptidylglycine α-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine α-amidating monooxygenase. J. Biol. Chem. 274:1999;34646-34656.
7. Cappione A.J., French B.L., Skuse G.R. A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. Am. J. Hum. Genet. 60:1997;305-312.
8. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
9. Chopra S., Fernandez D.M., Lam E.W., Mann D.J. Jab1 Co-activation of c-Jun Is Abrogated by the Serine 10-phosphorylated Form of p27Kip1. J. Biol. Chem. 277:2002;32413-32416.
10. Cichowski K., Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell. 104:2001;593-604.
11. Gutmann D.H., Zhang Y., Hirbe A. Developmental regulation of a neuron-specific neurofibromatosis 1 isoform. Ann. Neurol. 46:1999;777-782.
12. Henrique D., Adam J., Myat A., Chitnis A., Lewis J., Ish-Horowicz D. Expression of a Delta homologue in prospective neurons in the chick. Nature. 375:1995;787-790.
13. Ishida N., Kitagawa M., Hatakeyama S., Nakayama K. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J. Biol. Chem. 275:2000;25146-25154.
14. Ishida N., Hara T., Kamura T., Yoshida M., Nakayama K., Nakayama K.I. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J. Biol. Chem. 277:2002;14355-14358.
15. Kaufmann D., Leistner W., Kruse P., Kenner O., Hoffmeyer S., Hein C., Vogel W., Messiaen L., Bartelt B. Aberrant splicing in several human tumors in the tumor suppressor genes neurofibromatosis type 1, neurofibromatosis type 2, and tuberous sclerosis 2. Cancer Res. 62:2002;1503-1509.
16. Kourea H.P., Cordon-Cardo C., Dudas M., Leung D., Woodruff J.M. Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas. Am. J. Pathol. 155:1999;1885-1891.
17. Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:1987;8125-8148.
18. Maucuer A., Camonis J.H., Sobel A. Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc. Natl. Acad. Sci. USA. 92:1995;3100-3104.
19. Maucuer A., Le Caer J.P., Manceau V., Sobel A. Specific Ser-Pro phosphorylation by the RNA-recognition motif containing kinase KIS. Eur. J. Biochem. 267:2000;4456-4464.
20. Maucuer A., Ozon S., Manceau V., Gavet O., Lawler S., Curmi P., Sobel A. KIS is a protein kinase with an RNA recognition motif. J. Biol. Chem. 272:1997;23151-23156.
21. Messiaen L.M., Callens T., Mortier G., Beysen D., Vandenbroucke I., Van Roy N., Speleman F., Paepe A.D. Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects. Hum. Mutat. 15:2000;541-555.
22. Mukhopadhyay D., Anant S., Lee R.M., Kennedy S., Viskochil D., Davidson N.O. C→U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. Am. J. Hum. Genet. 70:2002;38-50.
23. Nakayama K., Ishida N., Shirane M., Inomata A., Inoue T., Shishido N., Horii I., Loh D.Y., Nakayama K. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 85:1996;707-720.
24. Philipp-Staheli J., Payne S.R., Kemp C.J. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp. Cell Res. 264:2001;148-168.
25. Rodier G., Montagnoli A., Di Marcotullio L., Coulombe P., Draetta G.F., Pagano M., Meloche S. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 20:2001;6672-6682.
26. Sgambato A., Cittadini A., Faraglia B., Weinstein I.B. Multiple functions of p27(Kip1) and its alterations in tumor cells: a review. J. Cell. Physiol. 183:2000;18-27.
27. Skuse G.R., Cappione A.J. RNA processing and clinical variability in neurofibromatosis type I (NF1). Hum. Mol. Genet. 6:1997;1707-1712.
28. Vandenbroucke I., Callens T., De Paepe A., Messiaen L. Complex splicing pattern generates great diversity in human NF1 transcripts, BMC. Genomics. 3:2002;13.
29. Zamore P.D., Patton J.G., Green M.R. Cloning and domain structure of the mammalian splicing factor U2AF. Nature. 355:1992;609-614.