Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress

Stress

Volumn 11, Issue 5, 2008, Pages 363-369

  Kawakami, Akio ^a,c   Okada, Nobukazu ^a   Rokkaku, Kumiko ^a   Honda, Kazufumi ^a   Ishibashi, Shun ^a   Onaka, Tatsushi ^a,b  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b Department of Physiology   (Japan)

^c Kawakami Medical Clinic   (Japan)

Author keywords

ACTH; Ghrelin; Hypothalamic paraventricular nucleus; Leptin; Microdialysis; Noradrenaline

Indexed keywords

CORTICOSTEROID; GHRELIN; LEPTIN; NORADRENALIN;

ANIMAL EXPERIMENT; ARTICLE; CORTICOSTEROID BLOOD LEVEL; FOOD DEPRIVATION; FOOTSHOCK; HYPOTHALAMUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; MALE; NEUROENDOCRINOLOGY; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; STRESS;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; ELECTRIC STIMULATION; FOOD DEPRIVATION; GHRELIN; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MICRODIALYSIS; NOREPINEPHRINE; RATS; RATS, WISTAR; STRESS, PSYCHOLOGICAL;

EID: 52149118907     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.1080/10253890701820257     Document Type: Article

References (36)

1. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. 1996. Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252.
2. Brady LS, Smith MA, Gold PW, Herkenham M. 1990. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52:441-447B.
3. Brunetti L, Michelotto B, Orlando G, Vacca M. 1999. Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings. Eur J Pharmacol 372:237-240.
4. Brunetti L, Recinella G, Orlando B, Michelotto B, DiNisio C, Vacca M. 2002. Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. Eur J Pharmacol 454:189-192.
5. Coll AP, Farooqi IS, O'Rahilly S. 2007. The hormonal control of food intake. Cell 129:251-262.
6. Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. 2003. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661.
7. Cummings DE. 2006. Ghrelin and the short- and long-term regulation of appetite and body weight. Physiol Behav 89:71-84.
8. Cunningham ET, Jr., Sawchenko PE. 1988. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 274:60-76.
9. De Boer SF, Koopmans SJ, Slangen JL, Van der Gugten J. 1989. Effects of fasting on plasma catecholamine, corticosterone and glucose concentrations under basal and stress conditions in individual rats. Physiol Behav 45:989-994.
10. Douglas AJ. 2005. Central noradrenergic mechanisms underlying acute stress responses of the hypothalamo-pituitary-adrenal axis: Adaptations through pregnancy and lactation. Stress 8:5-18.
11. Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. 2000. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395:535-547.
12. Francis J, MohanKumar SM, MohanKumar PS. 2004. Leptin inhibits norepinephrine efflux from the hypothalamus in vitro: Role of gamma aminobutyric acid. Brain Res 1021:286-291.
13. Grill HJ, Schwartz MW, Kaplan JM, Foxhall JS, Breininger J, Baskin DG. 2002. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143:239-246.
14. Hastings JA, Wiesner G, Lambert G, Morris MJ, Head G, Esler M. 2002. Influence of leptin on neurotransmitter overflow from the rat brain in vitro. Regul Pept 103:67-74.
15. Hay-Schmidt A, Helboe L, Larsen PJ. 2001. Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat. Neuroendocrinology 73:215-226.
16. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS. 1997. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 138:3859-3863.
17. Hosoda H, Kojima M, Kangawa K. 2006. Biological, physiological, and pharmacological aspects of ghrelin. J Pharmacol Sci 100:398-410.
18. Huang Q, Rivest R, Richard D. 1998. Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice. Endocrinology 139:1524-1532.
19. Itoi K, Jiang Y-Q, Iwasaki Y, Watson SJ. 2004. Regulatory-mechanisms of corticotrophin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol 16:348-355.
20. Jhanwar-Uniyal M, Darwish M, Levin BE, Leibowitz SF. 1987. Alterations in catecholamine levels and turnover in discrete brain areas after food deprivation. Pharmacol Biochem Behav 26:271-275.
21. Kiss A, Jezova D, Aguilera G. 1994. Activity of the hypothalamic pituitary adrenal axis and sympathoadrenal system during food and water deprivation in the rat. Brain Res 663:84-92.
22. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. 2004. Ghrelin - A hormone with multiple functions. Front Neuroendocrinol 25:27-68.
23. Kyroum I, Chrousos GP, Tsigos C. 2006. Stress, visceral obesity, and metabolic complications. Ann NY Acad Sci 1083:77-110.
24. Ludwig M, Onaka T, Yagi K. 2000. Vasopressin regulation of noradrenaline release within the supraoptic nucleus. J Neuroendocrinol 12:477-479.
25. Marriage BJ, Johnston JL. 1989. Hypothalamic norepinephrine synthesis rate in overfed, underfed and fasted mice. Pharmacol Biochem Behav 32:101-110.
26. Mercer JG, Moat KM, Hoggard N. 1998. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 139:29-34.
27. Ogasa T, Hashimoto K, Suemaru S, Kageyama J, Ota Z. 1992. The magnocellular arginine-vasopressin mRNA responds differently to food deprivation between the supraoptic and paraventricular nuclei of the hypothalamus in adrenalectomized rats with low-corticosterone replacement. Brain Res 583:45-53.
28. Pacak K, Palkovits M. 2001. Stressor specificity of central neuroendocrine responses: Implications for stress-related disorders. Endocr Rev 22:502-548.
29. Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S. 2003. Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors. Neuroreport 14:1997-2000.
30. Ruiz-Gayo M, Garrido MM, Fuentes JA. 2000. Inhibition of the hypothalamic-pituitary-adrenal axis in food-deprived rats by a CCK-A receptor antagonist. Br J Pharmacol 129:839-842.
31. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. 1996. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106.
32. Stanley BG, Schwartz DH, Hernandez L, Hoebel BG, Leibowitz SF. 1989. Patterns of extracellular norepinephrine in the paraventricular hypothalamus: Relationship to circadian rhythm and deprivation-induced eating behaviour. Life Sci 45:275-282.
33. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K, Matsukura S. 2001. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 281:1220-1225.
34. Wren AM, Small CJ, Fribbens CV, Neary NM, Ward HL, Seal LJ, Ghatei MA, Bloom SR. 2002. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology 76:316-324.
35. Ziegler DR, Cass WA, Herman JP. 1999. Excitatory influence of the locus coeruleus in hypothalamic-pituitary-adrenocortical axis responses to stress. J Neuroendocrinol 11:361-369.
36. Zigman JM, Elmquist JK. 2003. From anorexia to obesity - The yin and yang of body weight control. Endocrinology 144:3749-3756.