Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells

Molecular Medicine Reports

Volumn 6, Issue 3, 2012, Pages 675-681

  Yan, Bin ^a   Fu, Qihong ^b   Lai, Lihua ^c   Tao, Xinran ^c   Fei, Yanghonghong ^c   Shen, Jiangen ^c   Chen, Zuodong ^a   Wang, Qingqing ^c  

^a NINGBO FIRST HOSPITAL   (China)

^b HANGZHOU NORMAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cell survival; Mammalian target of rapamycin; MicroRNA 99a; Oral squamous cell carcinomas

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 99A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION;

3' UNTRANSLATED REGIONS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HEK293 CELLS; HUMANS; MICRORNAS; MOUTH NEOPLASMS; TOR SERINE-THREONINE KINASES;

EID: 84865194677     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.971     Document Type: Article

References (39)

1. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233, 2009.
2. Xu P, Guo M and Hay BA: MicroRNAs and the regulation of cell death. Trends Genet 20: 617-624, 2004. (Pubitemid 39441280)
3. Karp X and Ambros V: Developmental biology. Encountering microRNAs in cell fate signaling. Science 310: 1288-1289, 2005. (Pubitemid 41698853)
4. Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86, 2004. (Pubitemid 38055775)
5. Poy MN, Eliasson L, Krutzfeldt J, et al: A pancreatic isletspecific microRNA regulates insulin secretion. Nature 432: 226-230, 2004. (Pubitemid 39545853)
6. Garzon R, Fabbri M, Cimmino A, Calin GA and Croce CM: MicroRNA expression and function in cancer. Trends Mol Med 12: 580-587, 2006. (Pubitemid 44780201)
7. Hermeking H: p53 enters the microRNA world. Cancer Cell 12: 414-418, 2007.
8. Massano J, Regateiro FS, Januário G and Ferreira A: Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102: 67-76, 2006. (Pubitemid 44016111)
9. Wu BH, Xiong XP, Jia J and Zhang WF: MicroRNAs: new actors in the oral cancer scene. Oral Oncol 47: 314-319, 2011.
10. Li J, Huang H, Sun L, et al: MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin Cancer Res 15: 3998-4008, 2009.
11. Wong TS, Liu XB, Wong BY, et al: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 14: 2588-2592, 2008.
12. Wong TS, Liu XB, Chung-Wai Ho A, et al: Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. Int J Cancer 123: 251-257, 2008.
13. Jiang L, Liu X, Kolokythas A, et al: Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer 127: 505-512, 2010.
14. Liu Y, Chen Q, Song Y, et al: MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett 585: 1963-1968, 2011.
15. Wang QQ, Li H, Oliver T, et al: Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. J Immunol 180: 2419-2428, 2008.
16. Yellen P, Saqcena M, Salloum D, et al: High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle 10: 3948-3956, 2011.
17. Chen CH and Sarbassov dos D: The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2. J Biol Chem 286: 40386-40394, 2011.
18. Liao YM, Kim C and Yen Y: Mammalian target of rapamycin and head and neck squamous cell carcinoma. Head Neck Oncol 3: 22, 2011.
19. Chang KY, Tsai SY, Wu CM, et al: Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. Clin Cancer Res 17: 7116-7126, 2011.
20. Yang CJ, Shen WG, Liu CJ, et al: miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. J Oral Pathol Med 40: 560-566, 2011.
21. Wiklund ED, Gao S, Hulf T, et al: MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. PLoS One 6: e27840, 2011.
22. Yang CC, Hung PS, Wang PW, et al: miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma. J Oral Pathol Med 40: 397-404, 2011.
23. Yu CC, Chen YW, Chiou GY, et al: MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. Oral Oncol 47: 202-210, 2011.
24. Yu ZW, Zhong LP, Ji T, et al: MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines. Oral Oncol 46: 317-322, 2010.
25. Lo WL, Yu CC, Chiou GY, et al: MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J Pathol 223: 482-495, 2010.
26. Gomes CC and Gomez RS: MicroRNA and oral cancer: future perspectives. Oral Oncol 44: 910-914, 2008.
27. Coutte L, Dreyer C, Sablin MP, Faivre S and Raymond E: PI3KAKT-mTOR pathway and cancer. Bull Cancer 99: 173-180, 2012 (In French).
28. Seeliger H, Guba M, Kleespies A, Jauch KW and Bruns CJ: Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev 26: 611-621, 2007. (Pubitemid 350115107)
29. Aissat N, Le Tourneau C, Ghoul A, et al: Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines. Cancer Chemother Pharmacol 62: 305-313, 2008. (Pubitemid 351692089)
30. Fingar DC, Richardson CJ, Tee AR, et al: mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24: 200-216, 2004. (Pubitemid 38010048)
31. Grewe M, Gansauge F, Schmid RM, Adler G and Seufferlein T: Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res 59: 3581-3587, 1999. (Pubitemid 29381856)
32. Sun D, Lee YS, Malhotra A, et al: miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation. Cancer Res 71: 1313-1324, 2011.
33. Li D, Liu X, Lin L, et al: MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem 286: 36677-36685, 2011.
34. Yamada H, Yanagisawa K, Tokumaru S, et al: Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer. Genes Chromosomes Cancer 47: 810-818, 2008.
35. Nam EJ, Yoon H, Kim SW, et al: MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 14: 2690-2695, 2008.
36. Catto JW, Miah S, Owen HC, et al: Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res 69: 8472-8481, 2009.
37. Hermeking H: The miR-34 family in cancer and apoptosis. Cell Death Differ 17: 193-199, 2010.
38. He L, Thomson JM, Hemann MT, et al: A microRNA polycistron as a potential human oncogene. Nature 435: 828-833, 2005. (Pubitemid 40839734)
39. Minor J, Wang X, Zhang F, et al: Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. Oral Oncol 48: 73-78, 2012.