-
1
-
-
69349097813
-
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
-
Amundadottir,L. et al. (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat. Genet., 41, 986-990.
-
(2009)
Nat. Genet.
, vol.41
, pp. 986-990
-
-
Amundadottir, L.1
-
2
-
-
77649188501
-
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1.1q32. 1 and 5p. 15. 33
-
Petersen,G.M. et al. (2010) A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p.15.33. Nat. Genet., 42, 224-228.
-
(2010)
Nat. Genet.
, vol.42
, pp. 224-228
-
-
Petersen, G.M.1
-
3
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
WTCCC
-
WTCCC. (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
4
-
-
78549251736
-
Analysing biological pathways in genome-wide association studies
-
Wang,K. et al. (2010) Analysing biological pathways in genome-wide association studies. Nat. Rev. Genet., 11, 843-854.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 843-854
-
-
Wang, K.1
-
5
-
-
73149103718
-
Prioritizing GWAS results: a review of statistical methods and recommendations for their application
-
Cantor,R.M. et al. (2010) Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am. J. Hum. Genet., 86, 6-22.
-
(2010)
Am. J. Hum. Genet.
, vol.86
, pp. 6-22
-
-
Cantor, R.M.1
-
6
-
-
67651053605
-
Pathway analysis by adaptive combination of P-values
-
Yu,K. et al. (2009) Pathway analysis by adaptive combination of P-values. Genet. Epidemiol., 33, 700-709.
-
(2009)
Genet. Epidemiol.
, vol.33
, pp. 700-709
-
-
Yu, K.1
-
8
-
-
12744269194
-
Identifying interacting SNPs using Monte Carlo logic regression
-
Kooperberg,C. et al. (2005) Identifying interacting SNPs using Monte Carlo logic regression. Genet. Epidemiol., 28, 157-170.
-
(2005)
Genet. Epidemiol.
, vol.28
, pp. 157-170
-
-
Kooperberg, C.1
-
9
-
-
0037102434
-
A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma
-
Duell,E.J. et al. (2002) A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. Cancer Res., 62, 4630-4636.
-
(2002)
Cancer Res
, vol.62
, pp. 4630-4636
-
-
Duell, E.J.1
-
10
-
-
33845624102
-
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk
-
Jiao,L. et al. (2007) The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. Cancer Lett., 245, 61-68.
-
(2007)
Cancer Lett
, vol.245
, pp. 61-68
-
-
Jiao, L.1
-
11
-
-
66649091509
-
Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L
-
McWilliams,R.R. et al. (2009) Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L. Cancer Epidemiol. Biomarkers Prev., 18, 1295-1302.
-
(2009)
Cancer Epidemiol. Biomarkers Prev.
, vol.18
, pp. 1295-1302
-
-
McWilliams, R.R.1
-
12
-
-
21244485747
-
Type-II diabetes and pancreatic cancer: a metaanalysis of 36 studies
-
Huxley,R. et al. (2005) Type-II diabetes and pancreatic cancer: a metaanalysis of 36 studies. Br. J. Cancer, 92, 2076-2083.
-
(2005)
Br. J. Cancer
, vol.92
, pp. 2076-2083
-
-
Huxley, R.1
-
13
-
-
28944443806
-
Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers
-
Stolzenberg-Solomon,R.Z. et al. (2005) Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA, 294, 2872-2878.
-
(2005)
JAMA
, vol.294
, pp. 2872-2878
-
-
Stolzenberg-Solomon, R.Z.1
-
14
-
-
11844259994
-
Fasting serum glucose level and cancer risk in Korean men and women
-
Jee,S.H. et al. (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA, 293, 194-202.
-
(2005)
JAMA
, vol.293
, pp. 194-202
-
-
Jee, S.H.1
-
15
-
-
0034679058
-
Abnormal glucose metabolism and pancreatic cancer mortality
-
Gapstur,S.M. et al. (2000) Abnormal glucose metabolism and pancreatic cancer mortality. JAMA, 283, 2552-2558.
-
(2000)
JAMA
, vol.283
, pp. 2552-2558
-
-
Gapstur, S.M.1
-
16
-
-
0032823125
-
Chronic pancreatitis and other risk factors for pancreatic cancer
-
Lowenfels,A.B. et al. (1999) Chronic pancreatitis and other risk factors for pancreatic cancer. Gastroenterol. Clin. North Am., 28, 673-685.
-
(1999)
Gastroenterol. Clin. North Am.
, vol.28
, pp. 673-685
-
-
Lowenfels, A.B.1
-
17
-
-
83455198192
-
Selected medical conditions and risk of pancreatic cancer
-
Olson,S.H. (2012) Selected medical conditions and risk of pancreatic cancer. Mol. Carcinog., 51, 75-97.
-
(2012)
Mol. Carcinog.
, vol.51
, pp. 75-97
-
-
Olson, S.H.1
-
18
-
-
42049106907
-
Assembly of inflammation-related genes for pathway-focused genetic analysis
-
Loza,M.J. et al. (2007) Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One, 2, e1035.
-
(2007)
PLoS One
, vol.2
-
-
Loza, M.J.1
-
19
-
-
42349083585
-
Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation
-
Zaret,K.S. (2008) Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat. Rev. Genet., 9, 329-340.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 329-340
-
-
Zaret, K.S.1
-
20
-
-
57349112286
-
Generation and regeneration of cells of the liver and pancreas
-
Zaret,K.S. et al. (2008) Generation and regeneration of cells of the liver and pancreas. Science, 322, 1490-1494.
-
(2008)
Science
, vol.322
, pp. 1490-1494
-
-
Zaret, K.S.1
-
21
-
-
0035512077
-
Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism
-
Shih,D.Q. et al. (2001) Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes, 50, 2472-2480.
-
(2001)
Diabetes
, vol.50
, pp. 2472-2480
-
-
Shih, D.Q.1
-
22
-
-
2342459110
-
LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis
-
Fayard,E. et al. (2004) LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol., 14, 250-260.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 250-260
-
-
Fayard, E.1
-
23
-
-
38449088965
-
Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth
-
Maestro,M.A. et al. (2007) Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth. Endocr. Dev., 12, 33-45.
-
(2007)
Endocr. Dev.
, vol.12
, pp. 33-45
-
-
Maestro, M.A.1
-
24
-
-
38449097357
-
Transcription factors in pancreatic development
-
Martin,M. et al. (2007) Transcription factors in pancreatic development. Animal models. Endocr. Dev., 12, 24-32.
-
(2007)
Animal models. Endocr. Dev.
, vol.12
, pp. 24-32
-
-
Martin, M.1
-
25
-
-
52049119853
-
PDX-1 functions as a master factor in the pancreas
-
Kaneto,H. et al. (2008) PDX-1 functions as a master factor in the pancreas. Front Biosci., 13, 6406-6420.
-
(2008)
Front Biosci
, vol.13
, pp. 6406-6420
-
-
Kaneto, H.1
-
26
-
-
0141781123
-
Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development
-
Annicotte,J.S. et al. (2003) Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol. Cell. Biol, 23, 6713-6724.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 6713-6724
-
-
Annicotte, J.S.1
-
27
-
-
79959912879
-
Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus
-
Pierce,B.L. et al. (2011) Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus. Cancer Res., 71, 4352-4358.
-
(2011)
Cancer Res
, vol.71
, pp. 4352-4358
-
-
Pierce, B.L.1
-
28
-
-
13444257370
-
Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
-
Haumaitre,C. et al. (2005) Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc. Natl Acad. Sci. USA, 102, 1490-1495.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1490-1495
-
-
Haumaitre, C.1
-
30
-
-
0031007206
-
Novel mutations and a mutational hotspot in the MODY3 gene
-
Glucksmann,M.A. et al. (1997) Novel mutations and a mutational hotspot in the MODY3 gene. Diabetes, 46, 1081-1086.
-
(1997)
Diabetes
, vol.46
, pp. 1081-1086
-
-
Glucksmann, M.A.1
-
31
-
-
34447134182
-
Exonic duplication of the hepatocyte nuclear factor-1beta gene (transcription factor 2, hepatic) as a cause of maturity onset diabetes of the young type 5
-
Carette,C. et al. (2007) Exonic duplication of the hepatocyte nuclear factor-1beta gene (transcription factor 2, hepatic) as a cause of maturity onset diabetes of the young type 5. J. Clin. Endocrinol. Metab., 92, 2844-2847.
-
(2007)
J. Clin. Endocrinol. Metab.
, vol.92
, pp. 2844-2847
-
-
Carette, C.1
-
32
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
Voight,B.F. et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet., 42, 579-589.
-
(2010)
Nat. Genet.
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
-
33
-
-
0036347934
-
Nonsense and missense mutations in the human hepatocyte nuclear factor-1 beta gene (TCF2) and their relation to type 2 diabetes in Japanese
-
Furuta,H. et al. (2002) Nonsense and missense mutations in the human hepatocyte nuclear factor-1 beta gene (TCF2) and their relation to type 2 diabetes in Japanese. J. Clin. Endocrinol. Metab., 87, 3859-3863.
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 3859-3863
-
-
Furuta, H.1
-
34
-
-
33750954749
-
Common variants in HNF-1 alpha and risk of type 2 diabetes
-
Holmkvist,J. et al. (2006) Common variants in HNF-1 alpha and risk of type 2 diabetes. Diabetologia, 49, 2882-2891.
-
(2006)
Diabetologia
, vol.49
, pp. 2882-2891
-
-
Holmkvist, J.1
-
35
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes,E.K. et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet., 42, 937-948.
-
(2010)
Nat. Genet.
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
-
36
-
-
79959560633
-
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects
-
Lee,J.M. et al. (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects,. Nature, 474, 506-510.
-
(2011)
Nature
, vol.474
, pp. 506-510
-
-
Lee, J.M.1
-
37
-
-
77951222415
-
Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium
-
D'Angelo,A. et al. (2010) Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development, 137, 1573-1582.
-
(2010)
Development
, vol.137
, pp. 1573-1582
-
-
D'Angelo, A.1
-
38
-
-
77957879997
-
Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation
-
Lussier,C.R. et al. (2010) Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS One, 5, e12378.
-
(2010)
PLoS One
, vol.5
-
-
Lussier, C.R.1
-
39
-
-
0037622021
-
Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability
-
Laurent-Puig,P. et al. (2003) Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability. Gastroenterology, 124, 1311-1314.
-
(2003)
Gastroenterology
, vol.124
, pp. 1311-1314
-
-
Laurent-Puig, P.1
-
40
-
-
6344252624
-
Mutation of TCF1 encoding hepatocyte nuclear factor 1alpha in gynecological cancer
-
Rebouissou,S. et al. (2004) Mutation of TCF1 encoding hepatocyte nuclear factor 1alpha in gynecological cancer. Oncogene, 23, 7588-7592.
-
(2004)
Oncogene
, vol.23
, pp. 7588-7592
-
-
Rebouissou, S.1
-
41
-
-
18644363653
-
Bi-allelic inactivation of TCF1 in hepatic adenomas
-
Bluteau,O. et al. (2002) Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat. Genet., 32, 312-315.
-
(2002)
Nat. Genet.
, vol.32
, pp. 312-315
-
-
Bluteau, O.1
-
42
-
-
75449090631
-
Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis
-
Pelletier,L. et al. (2010) Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis. Hepatology, 51, 557-566.
-
(2010)
Hepatology
, vol.51
, pp. 557-566
-
-
Pelletier, L.1
-
43
-
-
84975742481
-
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1alpha as a master regulator of plasma protein fucosylation
-
Lauc,G. et al. (2010) Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1alpha as a master regulator of plasma protein fucosylation. PLoS Genet., 6, e1001256.
-
(2010)
PLoS Genet
, vol.6
-
-
Lauc, G.1
-
44
-
-
78049501826
-
Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of c-reactive protein and coronary artery disease (the ludwigshafen risk and cardiovascular health study)
-
Kleber,M.E. et al. (2010) Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of c-reactive protein and coronary artery disease (the ludwigshafen risk and cardiovascular health study). BMC Med. Genet., 11, 157.
-
(2010)
BMC Med. Genet.
, vol.11
, pp. 157
-
-
Kleber, M.E.1
-
45
-
-
77955652045
-
Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a populationbased epidemiological study
-
Ley,S.H. et al. (2010) Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a populationbased epidemiological study. Cardiovasc. Diabetol., 9, 39.
-
(2010)
Cardiovasc. Diabetol.
, vol.9
, pp. 39
-
-
Ley, S.H.1
-
46
-
-
34248193253
-
Immune surveillance of tumors
-
Swann,J.B. et al. (2007) Immune surveillance of tumors. J. Clin. Invest., 117, 1137-1146.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1137-1146
-
-
Swann, J.B.1
-
47
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones,S. et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science, 321, 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
48
-
-
0032404111
-
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
-
Goggins,M. et al. (1998) Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res., 58, 5329-5332.
-
(1998)
Cancer Res
, vol.58
, pp. 5329-5332
-
-
Goggins, M.1
-
49
-
-
79953750882
-
Chemokines and cancer: a fatal attraction
-
Bonecchi,R. et al. (2011) Chemokines and cancer: a fatal attraction. Cancer Cell, 19, 434-435.
-
(2011)
Cancer Cell
, vol.19
, pp. 434-435
-
-
Bonecchi, R.1
-
50
-
-
77956185248
-
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
-
Sabio,G. et al. (2010) cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem. Sci., 35, 490-496.
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 490-496
-
-
Sabio, G.1
|