Hypoferraemia during the early inflammatory response is dependent on tumour necrosis factor activity in a murine model of protracted peritonitis

Molecular Medicine Reports

Volumn 6, Issue 4, 2012, Pages 838-842

  Schubert, Thomas E O ^a,d   Bosserhoff, Anja K ^a   Peyssonaux, Carole ^b   Echtenacher, Bernd ^a   Knutson, Mitchell ^c   Hofstädter, Ferdinand ^a   Männel, Daniela N ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b INSERM   (France)

^c UNIVERSITY OF FLORIDA   (United States)

^d Institute of Applied Pathology   (Germany)

Author keywords

Blood; Hypoferraemia; Mouse; Septic peritonitis; TNF

Indexed keywords

FERROPORTIN 1; HEPCIDIN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEFENSE MECHANISM; DOWN REGULATION; FEMALE; HYPOFERRAEMIA; IN VITRO STUDY; IN VIVO STUDY; IRON BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PERITONITIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANEMIA; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATION TRANSPORT PROTEINS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; HEPCIDINS; IRON; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERITONITIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84865166624     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1004     Document Type: Article

References (20)

1. Weiss G: Modification of iron regulation by the inflammatory response (Review). Best Pract Res Clin Haematol 18: 183-201, 2005.
2. Schaible UE and Kaufmann SH: Iron and microbial infection. Nat Rev Microbiol 2: 946-953, 2004. (Pubitemid 39562533)
3. Laftah AH, Sharma N, Brookes MJ, McKie AT, Simpson RJ, Iqbal TH and Tselepis C: Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice. Biochem J 397: 61-67, 2006. (Pubitemid 44032837)
4. Johnson RA, Waddelow TA, Caro J, Oliff A and Roodman GD: Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 74: 130-138, 1989. (Pubitemid 19187420)
5. Feelders RA, Vreugdenhil G, Eggermont AM, Kuiper-Kramer PA, van Eijk HG and Swaak AJ: Regulation of iron metabolism in the acute-phase response: interferon gamma and tumour necrosis factor alpha induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients. Eur J Clin Invest 28: 520-527, 1998. (Pubitemid 28350015)
6. Alvarez-Hernández X, Licéaga J, McKay IC and Brock JH: Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor. Lab Invest 61: 319-322, 1989. (Pubitemid 19249645)
7. Sharma N, Laftah AH, Brookes MJ, Cooper B, Iqbal T and Tselepis C: A role for tumour necrosis factor alpha in human small bowel iron transport. Biochem J (Pt 2) 390: 437-446, 2005. (Pubitemid 41337105)
8. Ludwiczek S, Aigner E, Theurl I and Weiss G: Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 101: 4148-4154, 2003. (Pubitemid 36857898)
9. Körner H, Cook M, Riminton DS, Lemckert FA, Hoek RM, Ledermann B, Köntgen F, Fazekas de St Groth B and Sedgwick JD: Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-2609, 1997. (Pubitemid 27453850)
10. Schubert TE, Echtenacher B, Hofstädter F and Männel DN: Failure of interferon-γ and tumor necrosis factor in mediating anemia of chronic disease in a mouse model of protracted septic peritonitis. Int J Mol Med 16: 753-758, 2005.
11. Tanaka T, Araki E, Nitta K and Tateno M: Recombinant human tumor necrosis factor depresses serum iron in mice. J Biol Response Mod 6: 484-488, 1987. (Pubitemid 17164212)
12. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T and Kaplan J: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093, 2004. (Pubitemid 40007660)
13. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D and Ganz T: Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 106: 2196-2199, 2005. (Pubitemid 41291740)
14. Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS and Nizet V: TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107: 3727-3732, 2006.
15. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A and Vaulont S: The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110: 1037-1044, 2002.
16. Nanami M, Ookawara T, Otaki Y, Ito K, Moriguchi R, Miyagawa K, Hasuike Y, Izumi M, Eguchi H, Suzuki K and Nakanishi T: Tumor necrosis factor-alpha-induced iron sequestration and oxidative stress in human endothelial cells. Arterioscler Thromb Vasc Biol 25: 2495-2501, 2005. (Pubitemid 43732269)
17. Liu XB, Nguyen NB, Marquess KD, Yang F and Haile DJ: Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis 35: 47-56, 2005. (Pubitemid 40922774)
18. Yang F, Liu XB, Quinones M, Melby PC, Ghio A and Haile DJ: Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem 277: 39786-39791, 2002. (Pubitemid 35190962)
19. Schubert T, Echtenacher B, Hofstädter F and Männel DN: TNF-independent development of transient anemia of chronic disease in a mouse model of protracted septic peritonitis. Lab Invest 83: 1743-1750, 2003. (Pubitemid 38018537)
20. Ganz T and Nemeth E: Iron sequestration and anemia of inflammation. Semin Hematol 46: 387-393, 2009.