메뉴 건너뛰기




Volumn 4, Issue 5, 2012, Pages 413-427

Complexity and the reductionism-holism debate in systems biology

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DNA; PROTEIN; RNA;

EID: 84865159838     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.1181     Document Type: Article
Times cited : (72)

References (125)
  • 1
    • 77949479491 scopus 로고    scopus 로고
    • So what do we really mean when we say that systems biology is holistic?
    • doi:10.1186/1752-0509-4-22.
    • Gatherer D. So what do we really mean when we say that systems biology is holistic? BMC Syst Biol 2010, 4:22. doi:10.1186/1752-0509-4-22.
    • (2010) BMC Syst Biol , vol.4 , pp. 22
    • Gatherer, D.1
  • 2
    • 30444445381 scopus 로고    scopus 로고
    • Fundamental issues in systems biology.
    • doi:10. 1002/bies.20323.
    • O'Malley MA, Dupré J. Fundamental issues in systems biology. Bioessays 2005, 27:1270-1276. doi:10. 1002/bies.20323.
    • (2005) Bioessays , vol.27 , pp. 1270-1276
    • O'Malley, M.A.1    Dupré, J.2
  • 4
    • 21044443402 scopus 로고    scopus 로고
    • Search for organizing principles: understanding in sys tems biology.
    • doi:10.1049/sb:20045010.
    • Mesarovic MD, Sreenath SW, Keene JD. Search for organizing principles: understanding in sys tems biology. Syst Biol 2004, 1:19-27. doi:10.1049/sb:20045010.
    • (2004) Syst Biol , vol.1 , pp. 19-27
    • Mesarovic, M.D.1    Sreenath, S.W.2    Keene, J.D.3
  • 5
    • 5044227742 scopus 로고    scopus 로고
    • The evolution of molecular biology into systems biology.
    • doi:10.1038/nbt1020.
    • Westerhoff HV, Palsson BO. The evolution of molecular biology into systems biology. Nat Biotechnol 2004, 22:1249-1252. doi:10.1038/nbt1020.
    • (2004) Nat Biotechnol , vol.22 , pp. 1249-1252
    • Westerhoff, H.V.1    Palsson, B.O.2
  • 6
    • 0035464637 scopus 로고    scopus 로고
    • Systems biology: the reincarnation of systems theory applied in biology?
    • doi:10.1093/bib/2.3.258.
    • Wolkenhauer O. Systems biology: the reincarnation of systems theory applied in biology? Brief Bioinform 2001, 2:258-270. doi:10.1093/bib/2.3.258.
    • (2001) Brief Bioinform , vol.2 , pp. 258-270
    • Wolkenhauer, O.1
  • 7
    • 3242746852 scopus 로고    scopus 로고
    • Functional genomics and proteomics as a foundation for systems biology.
    • doi:10.1093/bfgp/2.3.175.
    • Aggarwal K, Lee KH. Functional genomics and proteomics as a foundation for systems biology. Brief Funct Genomic Proteomic 2003, 2:175-184. doi:10.1093/bfgp/2.3.175.
    • (2003) Brief Funct Genomic Proteomic , vol.2 , pp. 175-184
    • Aggarwal, K.1    Lee, K.H.2
  • 8
    • 46249113777 scopus 로고    scopus 로고
    • Will systems biology offer new holistic paradigm to life science?
    • doi:10.1007/s11693-008-9016-1.
    • Conti V, Valerio MC, Zbilut JP, Giuliani A. Will systems biology offer new holistic paradigm to life science? Syst Synth Biol 2007, 1:161-165. doi:10.1007/s11693-008-9016-1.
    • (2007) Syst Synth Biol , vol.1 , pp. 161-165
    • Conti, V.1    Valerio, M.C.2    Zbilut, J.P.3    Giuliani, A.4
  • 9
    • 7444253428 scopus 로고    scopus 로고
    • Systems biology and new technologies enable predictive and preventative medicine.
    • doi:10.1126/science.1104635.
    • Hood L, Heath JR, Phelps ME, Lin BY. Systems biology and new technologies enable predictive and preventative medicine. Science 2004, 306:640-643. doi:10.1126/science.1104635.
    • (2004) Science , vol.306 , pp. 640-643
    • Hood, L.1    Heath, J.R.2    Phelps, M.E.3    Lin, B.Y.4
  • 10
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology-a brief overview.
    • doi:10.1126/science.1069492.
    • Kitano H. Systems biology-a brief overview. Science 2002, 295:1662-1664. doi:10.1126/science.1069492.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 11
    • 48249098463 scopus 로고    scopus 로고
    • Does systems biology represent a Kuhnian paradigm shift?
    • doi:10.1111/j.1469-8137.2008.02486.x.
    • Marcum JA. Does systems biology represent a Kuhnian paradigm shift? New Phytol 2008, 179:587-589. doi:10.1111/j.1469-8137.2008.02486.x.
    • (2008) New Phytol , vol.179 , pp. 587-589
    • Marcum, J.A.1
  • 13
    • 33750993479 scopus 로고    scopus 로고
    • A brief history of systems biology. "Every object that biology studies is a system of systems." Francois Jacob (1974).
    • doi:10.1105/tpc.106.042267.
    • Trewavas A. A brief history of systems biology. "Every object that biology studies is a system of systems." Francois Jacob (1974). Plant Cell 2006, 18:2420-2430. doi:10.1105/tpc.106.042267.
    • (2006) Plant Cell , vol.18 , pp. 2420-2430
    • Trewavas, A.1
  • 14
    • 33644647421 scopus 로고    scopus 로고
    • The long past of systems biology.
    • doi:10.1111/j.1469-8137.2006.01676.x.
    • Bothwell JH. The long past of systems biology. New Phytol 2006, 170:6-10. doi:10.1111/j.1469-8137.2006.01676.x.
    • (2006) New Phytol , vol.170 , pp. 6-10
    • Bothwell, J.H.1
  • 16
    • 0001249865 scopus 로고
    • Models of reduction and categories of reductionism.
    • doi:10. 1007/BF00413566.
    • Sarkar S. Models of reduction and categories of reductionism. Synthese 1992, 91:167-194. doi:10. 1007/BF00413566.
    • (1992) Synthese , vol.91 , pp. 167-194
    • Sarkar, S.1
  • 19
    • 0006146822 scopus 로고
    • Newtonianism, reductionism and the art of congressional testimony.
    • doi:10.1038/330433a0.
    • Weinberg S. Newtonianism, reductionism and the art of congressional testimony. Nature 1987, 330: 433-437. doi:10.1038/330433a0.
    • (1987) Nature , vol.330 , pp. 433-437
    • Weinberg, S.1
  • 20
    • 0014937223 scopus 로고
    • central dogma of molecular biology.
    • doi:10.1038/227561a0.
    • Crick FHC. central dogma of molecular biology. Nature 1970, 227:561-563. doi:10.1038/227561a0.
    • (1970) Nature , vol.227 , pp. 561-563
    • Crick, F.H.C.1
  • 21
    • 54249116230 scopus 로고
    • Genetic regulatory mechanisms in the synthesis of proteins.
    • doi:10.1016/S0022-2836(61)80072-7.
    • Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol 1961, 3:318-356. doi:10.1016/S0022-2836(61)80072-7.
    • (1961) J Mol Biol , vol.3 , pp. 318-356
    • Jacob, F.1    Monod, J.2
  • 22
    • 0011147053 scopus 로고
    • Seattle: University of Washington Press;
    • Crick FHC. Of Molecules and Men. Seattle: University of Washington Press; 1966, 101.
    • (1966) Of Molecules and Men. , pp. 101
    • Crick, F.H.C.1
  • 23
    • 20744451293 scopus 로고    scopus 로고
    • How to reconcile physicalism and antireductionism about biology.
    • Rosenberg A, Kaplan DM. How to reconcile physicalism and antireductionism about biology. Philos Sci 2005, 72:43-68.
    • (2005) Philos Sci , vol.72 , pp. 43-68
    • Rosenberg, A.1    Kaplan, D.M.2
  • 24
    • 39549113170 scopus 로고    scopus 로고
    • Is epigenetic inheritance a counterexample to the central dogma?
    • Rosenberg A. Is epigenetic inheritance a counterexample to the central dogma? Hist Philos Life Sci 2006, 28:549-565.
    • (2006) Hist Philos Life Sci , vol.28 , pp. 549-565
    • Rosenberg, A.1
  • 25
    • 0001459345 scopus 로고    scopus 로고
    • Reductionism redux: computing the embryo.
    • doi:10.1023/A:1006574719901.
    • Rosenberg A. Reductionism redux: computing the embryo. Biol Philos 1997, 12:445-470. doi:10.1023/A:1006574719901.
    • (1997) Biol Philos , vol.12 , pp. 445-470
    • Rosenberg, A.1
  • 26
    • 0036969667 scopus 로고    scopus 로고
    • BioComplexity: a pluralist research strategy is necessary for a mechanistic explanation of the "live" state.
    • doi:10.1080/0951508021000041996.
    • Bruggeman FJ, Westerhoff HV, Boogerd FC. BioComplexity: a pluralist research strategy is necessary for a mechanistic explanation of the "live" state. Philos Psychol 2002, 15:411-440. doi:10.1080/0951508021000041996.
    • (2002) Philos Psychol , vol.15 , pp. 411-440
    • Bruggeman, F.J.1    Westerhoff, H.V.2    Boogerd, F.C.3
  • 28
    • 0030793904 scopus 로고    scopus 로고
    • Biologists cut reductionist approach down to size.
    • doi:10. 1126/science.277.5325.476.
    • Williams N. Biologists cut reductionist approach down to size. Science 1997, 277:476-477. doi:10. 1126/science.277.5325.476.
    • (1997) Science , vol.277 , pp. 476-477
    • Williams, N.1
  • 29
    • 0035327182 scopus 로고    scopus 로고
    • Brute force estimation of the number of human gene using EST clustering as a measure.
    • doi:10. 1147/rd.453.0439.
    • Davison DB, Burke J. Brute force estimation of the number of human gene using EST clustering as a measure. IBM J Res Dev 2001, 45:439-447. doi:10. 1147/rd.453.0439.
    • (2001) IBM J Res Dev , vol.45 , pp. 439-447
    • Davison, D.B.1    Burke, J.2
  • 30
    • 84865186582 scopus 로고    scopus 로고
    • Alternative splicing: a paradoxical qudo in eukaryotic genomes.
    • Kashyap L, Sharma RK. Alternative splicing: a paradoxical qudo in eukaryotic genomes. Bioinformation 2007, 2:155-156.
    • (2007) Bioinformation , vol.2 , pp. 155-156
    • Kashyap, L.1    Sharma, R.K.2
  • 33
    • 33748317780 scopus 로고    scopus 로고
    • Post-genomics, between reduction and emergence.
    • doi:10. 1007/s11229-006-9029-9.
    • Morange M. Post-genomics, between reduction and emergence. Synthese 2006, 151:355-360. doi:10. 1007/s11229-006-9029-9.
    • (2006) Synthese , vol.151 , pp. 355-360
    • Morange, M.1
  • 34
    • 0014690698 scopus 로고
    • Gene regulation for higher cells: a theory.
    • doi:10.1126/science.165.3891.349.
    • Britten RJ, Davidson E. Gene regulation for higher cells: a theory. Science 1969, 165:349-357. doi:10.1126/science.165.3891.349.
    • (1969) Science , vol.165 , pp. 349-357
    • Britten, R.J.1    Davidson, E.2
  • 36
    • 33645275449 scopus 로고    scopus 로고
    • Chromatin fiber functional organization: some plausible models.
    • Lesne A, Victor JM. Chromatin fiber functional organization: some plausible models. Eur Phys J E Soft Matter 2006, 19:279-290. Available at: http://dx.doi.org/10.1140/epje/i2005-10050-6.
    • (2006) Eur Phys J E Soft Matter , vol.19 , pp. 279-290
    • Lesne, A.1    Victor, J.M.2
  • 37
    • 0031092897 scopus 로고    scopus 로고
    • The coming Kuhnian revolution in biology.
    • doi:10. 1038/nbt0397-194.
    • Strohman RC. The coming Kuhnian revolution in biology. Nat Biotechnol 1997, 15:194-200. doi:10. 1038/nbt0397-194.
    • (1997) Nat Biotechnol , vol.15 , pp. 194-200
    • Strohman, R.C.1
  • 38
    • 22344452950 scopus 로고    scopus 로고
    • Towards a new paradigm of life-beyond genetic determinism.
    • Strohman RC. Towards a new paradigm of life-beyond genetic determinism. California Monthly 2001, 111:4-27.
    • (2001) California Monthly , vol.111 , pp. 4-27
    • Strohman, R.C.1
  • 39
    • 66149101662 scopus 로고    scopus 로고
    • Complex systems: from chemistry to systems biology.
    • doi:10.1073/pnas.0903406106.
    • Ross J, Arkin AP. Complex systems: from chemistry to systems biology. PNAS 2009, 106:6433-6434. doi:10.1073/pnas.0903406106.
    • (2009) PNAS , vol.106 , pp. 6433-6434
    • Ross, J.1    Arkin, A.P.2
  • 40
    • 37849034945 scopus 로고    scopus 로고
    • Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory.
    • doi:10.1038/sj.embor.7401147.
    • Mazzocchi F. Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory. EMBO Rep 2008, 9:10-14. doi:10.1038/sj.embor.7401147.
    • (2008) EMBO Rep , vol.9 , pp. 10-14
    • Mazzocchi, F.1
  • 41
    • 19344372271 scopus 로고    scopus 로고
    • Systems biology: its practice and challenges.
    • doi:10.1016/j.cell. 2005.04.020.
    • Aderem A. Systems biology: its practice and challenges. Cell 2005, 121:511-513. doi:10.1016/j.cell. 2005.04.020.
    • (2005) Cell , vol.121 , pp. 511-513
    • Aderem, A.1
  • 42
    • 0003034978 scopus 로고
    • A new discipline, a new name, a new journal.
    • doi:10. 1016/0888-7543(87)90098-X.
    • McKusick VA, Ruddle FH. A new discipline, a new name, a new journal. Genomics 1987, 1:1-2. doi:10. 1016/0888-7543(87)90098-X.
    • (1987) Genomics , vol.1 , pp. 1-2
    • McKusick, V.A.1    Ruddle, F.H.2
  • 43
    • 0030725715 scopus 로고    scopus 로고
    • Functional genomics: it's all how you read it.
    • doi:10.1126/science.278.5338.601
    • Hieter P, Boguski M. Functional genomics: it's all how you read it. Science 1997 278:601-602. doi:10.1126/science.278.5338.601.
    • (1997) Science , vol.278 , pp. 601-602
    • Hieter, P.1    Boguski, M.2
  • 44
    • 0030671393 scopus 로고    scopus 로고
    • Genomics: structural and functional studies of genomes.
    • doi:10.1006/geno.1997.5020.
    • McKusick VA. Genomics: structural and functional studies of genomes. Genomics 45:244-249. doi:10.1006/geno.1997.5020.
    • Genomics , vol.45 , pp. 244-249
    • McKusick, V.A.1
  • 47
    • 0035775725 scopus 로고    scopus 로고
    • A new approach to decoding life: systems biology.
    • doi:10.1146/annurev. genom.2.1.343.
    • Ideker T, Galitski T, Hood L. A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet 2001, 2:343-372. doi:10.1146/annurev. genom.2.1.343.
    • (2001) Annu Rev Genomics Hum Genet , vol.2 , pp. 343-372
    • Ideker, T.1    Galitski, T.2    Hood, L.3
  • 48
    • 0141561891 scopus 로고    scopus 로고
    • Integrating 'omic' information: a bridge between genomics and systems biology.
    • doi:10. 1016/j.tig.2003.08.009.
    • Ge H, Walhout AJM, Vidal M. Integrating 'omic' information: a bridge between genomics and systems biology. Trends Genet 2003, 19:551-560. doi:10. 1016/j.tig.2003.08.009.
    • (2003) Trends Genet , vol.19 , pp. 551-560
    • Ge, H.1    Walhout, A.J.M.2    Vidal, M.3
  • 49
    • 0345743608 scopus 로고    scopus 로고
    • Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis driven science in the post-genomic era.
    • doi:10.1002/bies.10385.
    • Kell DB, Oliver SG. Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis driven science in the post-genomic era. BioEssays 2004, 26:99-105. doi:10.1002/bies.10385.
    • (2004) BioEssays , vol.26 , pp. 99-105
    • Kell, D.B.1    Oliver, S.G.2
  • 50
    • 0347122082 scopus 로고    scopus 로고
    • From functional genomics to systems biology: concepts and practices.
    • doi:10.1016/j.crvi.2003.09.033.
    • Auffray C, Imbeaud S, Roux-Rouquié M, Hood L. From functional genomics to systems biology: concepts and practices. C R Biol 2003, 326:879-892. doi:10.1016/j.crvi.2003.09.033.
    • (2003) C R Biol , vol.326 , pp. 879-892
    • Auffray, C.1    Imbeaud, S.2    Roux-Rouquié, M.3    Hood, L.4
  • 51
    • 33745588546 scopus 로고    scopus 로고
    • The limits of reductionism in medicine: could systems biology offer an alternative?
    • doi:10.1371/journal.pmed.0030208.
    • Ahn AC, Tewari M, Poon C-S, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative? PloS Med 2006, 3:e208. doi:10.1371/journal.pmed.0030208.
    • (2006) PloS Med , vol.3
    • Ahn, A.C.1    Tewari, M.2    Poon, C.-S.3    Phillips, R.S.4
  • 52
    • 58149263489 scopus 로고    scopus 로고
    • Metabolomics and fluxomics approaches.
    • doi:10.1042/BSE0450067.
    • Cascante M, Marin S. Metabolomics and fluxomics approaches. Essays Biochem 2008, 45:67-81. doi:10.1042/BSE0450067.
    • (2008) Essays Biochem , vol.45 , pp. 67-81
    • Cascante, M.1    Marin, S.2
  • 53
    • 53249119181 scopus 로고    scopus 로고
    • Systems biology at the Institute for Systems Biology.
    • doi:10.1093/bfgp/eln027.
    • Hood L, Rowen L, Galas DJ, Aitchison JD. Systems biology at the Institute for Systems Biology. Brief Funct Genomic Proteomic 2008, 7:239-248. doi:10.1093/bfgp/eln027.
    • (2008) Brief Funct Genomic Proteomic , vol.7 , pp. 239-248
    • Hood, L.1    Rowen, L.2    Galas, D.J.3    Aitchison, J.D.4
  • 54
    • 33748434133 scopus 로고    scopus 로고
    • Getting to synaptic complexes through systems biology.
    • doi:10.1186/gb-2006-7-4-214.
    • Jordan BA, Ziff EB. Getting to synaptic complexes through systems biology. Genome Biol 2006, 7:214. doi:10.1186/gb-2006-7-4-214.
    • (2006) Genome Biol , vol.7 , pp. 214
    • Jordan, B.A.1    Ziff, E.B.2
  • 55
    • 37349057040 scopus 로고    scopus 로고
    • Claude Bernard, the first systems biologist, and the future of physiology.
    • doi:10.1113/expphysiol.2007.038695.
    • Noble D. Claude Bernard, the first systems biologist, and the future of physiology. Exp Physiol 2008, 93:16-26. doi:10.1113/expphysiol.2007.038695.
    • (2008) Exp Physiol , vol.93 , pp. 16-26
    • Noble, D.1
  • 56
    • 17644365470 scopus 로고    scopus 로고
    • The end of 'naive reductionism': rise systems biology or renaissance of physiology?
    • doi:10. 1152/ajpcell.00598.2004.
    • Strange K. The end of 'naive reductionism': rise systems biology or renaissance of physiology? Am J Physiol Cell Physiol 2005, 288:968-974. doi:10. 1152/ajpcell.00598.2004.
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. 968-974
    • Strange, K.1
  • 57
    • 27744436367 scopus 로고    scopus 로고
    • Molecular systems biology at the crossroads: to know less about more, or to know more about less?
    • doi:10.1186/1477-5956-3-8.
    • Latterich M. Molecular systems biology at the crossroads: to know less about more, or to know more about less? Proteome Sci 2005, 3:8. doi:10.1186/1477-5956-3-8.
    • (2005) Proteome Sci , vol.3 , pp. 8
    • Latterich, M.1
  • 58
    • 12344296457 scopus 로고    scopus 로고
    • A reductionist's systems biology.
    • doi:10.1016/j.ceb. 2004.12.012.
    • Sorger PK. A reductionist's systems biology. Curr Opin Cell Biol 2005, 17:9-11. doi:10.1016/j.ceb. 2004.12.012.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 9-11
    • Sorger, P.K.1
  • 59
    • 79953322640 scopus 로고    scopus 로고
    • Reductionistic and holistic science.
    • doi:10.1128/IAI.01343-10.
    • Fang FC, Casadevall A. Reductionistic and holistic science. Infect Immun 2011, 79:1401-1404. doi:10.1128/IAI.01343-10.
    • (2011) Infect Immun , vol.79 , pp. 1401-1404
    • Fang, F.C.1    Casadevall, A.2
  • 60
    • 34247953814 scopus 로고
    • More is different: broken symmetry and the nature of the hierarchical structure of science.
    • doi:10.1126/science.177.4047.393.
    • Anderson PW. More is different: broken symmetry and the nature of the hierarchical structure of science. Science 1972, 177:393-396. doi:10.1126/science.177.4047.393.
    • (1972) Science , vol.177 , pp. 393-396
    • Anderson, P.W.1
  • 61
    • 84873484603 scopus 로고    scopus 로고
    • No turning back: reductionism and biological complexity. Times Higher Educational Supplement 1991, 9.
    • Kell DB, Welch GR, No turning back: reductionism and biological complexity. Times Higher Educational Supplement 1991, 9.
    • Kell, D.B.1    Welch, G.R.2
  • 62
    • 3042721988 scopus 로고    scopus 로고
    • Back to the biology in systems biology: what can we learn from biomolecular networks?
    • doi:10.1093/bfgp/2.4.279.
    • Huang S. Back to the biology in systems biology: what can we learn from biomolecular networks? Brief Funct Genomic Proteomic 2004, 2:279-297. doi:10.1093/bfgp/2.4.279.
    • (2004) Brief Funct Genomic Proteomic , vol.2 , pp. 279-297
    • Huang, S.1
  • 63
    • 5044239903 scopus 로고    scopus 로고
    • A partnership between biology and engineering.
    • doi:10. 1038/nbt1004-1211.
    • Brent R. A partnership between biology and engineering. Nat Biotechnol 2004, 22:1211-1214. doi:10. 1038/nbt1004-1211.
    • (2004) Nat Biotechnol , vol.22 , pp. 1211-1214
    • Brent, R.1
  • 65
    • 85015077644 scopus 로고    scopus 로고
    • The digital code of DNA.
    • doi:10.1038/nature01410.
    • Hood L, Galas D. The digital code of DNA. Nature 2003, 421:444-448. doi:10.1038/nature01410.
    • (2003) Nature , vol.421 , pp. 444-448
    • Hood, L.1    Galas, D.2
  • 67
    • 21044455304 scopus 로고    scopus 로고
    • Systems biology may work when we learn to understand the parts in terms of the whole.
    • doi:10.1042/BST0330516.
    • Cornish-Bowden A, Cardenas ML. Systems biology may work when we learn to understand the parts in terms of the whole. Biochem Soc Trans 2005, 33:516-519. doi:10.1042/BST0330516.
    • (2005) Biochem Soc Trans , vol.33 , pp. 516-519
    • Cornish-Bowden, A.1    Cardenas, M.L.2
  • 68
    • 33750350831 scopus 로고    scopus 로고
    • Putting the systems back into systems biology.
    • doi:10.1353/pbm.2006.0053.
    • Cornish-Bowden A. Putting the systems back into systems biology. Perspect Biol Med 2006, 49:475-489. doi:10.1353/pbm.2006.0053.
    • (2006) Perspect Biol Med , vol.49 , pp. 475-489
    • Cornish-Bowden, A.1
  • 69
    • 38949198669 scopus 로고    scopus 로고
    • The new biology: beyond the modern synthesis.
    • doi:10.1186/1745-6150-2-30.
    • Rose MR, Oakley TH. The new biology: beyond the modern synthesis. Biol Direct 2007, 2:30. doi:10.1186/1745-6150-2-30.
    • (2007) Biol Direct , vol.2 , pp. 30
    • Rose, M.R.1    Oakley, T.H.2
  • 72
    • 51249194520 scopus 로고
    • Topology and life: in search of general mathematical principles in biology and sociology.
    • doi:10.1007/BF02484495.
    • Rashevsky N. Topology and life: in search of general mathematical principles in biology and sociology. Bull Math Biophys 1954, 16:317-348. doi:10.1007/BF02484495.
    • (1954) Bull Math Biophys , vol.16 , pp. 317-348
    • Rashevsky, N.1
  • 73
    • 37049235151 scopus 로고
    • The theory of open systems in physics and biology.
    • doi:10. 1126/science.111.2872.23.
    • von Bertallanfy L. The theory of open systems in physics and biology. Science 1950, 23-29. doi:10. 1126/science.111.2872.23.
    • (1950) Science , pp. 23-29
    • von Bertallanfy, L.1
  • 74
    • 73149086369 scopus 로고
    • An outline of general system theory.
    • doi:10.1093/bjps/I.2.134.
    • von Bertallanfy L. An outline of general system theory. Brit J for the Phil of Sci 1950, 1:134-165. doi:10.1093/bjps/I.2.134.
    • (1950) Brit J for the Phil of Sci , vol.1 , pp. 134-165
    • von Bertallanfy, L.1
  • 78
    • 0035011208 scopus 로고    scopus 로고
    • The parts list of life.
    • doi:10.1038/88044.
    • Bains W. The parts list of life. Nat Biotechnol 2001, 19:401-402. doi:10.1038/88044.
    • (2001) Nat Biotechnol , vol.19 , pp. 401-402
    • Bains, W.1
  • 79
    • 0035816464 scopus 로고    scopus 로고
    • Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway.
    • doi:10.1016/S0014-5793(01)02613-8.
    • ter Kuile BH, Westerhoff HV. Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. FEBS Lett 2001, 500:169-171. doi:10.1016/S0014-5793(01)02613-8.
    • (2001) FEBS Lett , vol.500 , pp. 169-171
    • ter Kuile, B.H.1    Westerhoff, H.V.2
  • 80
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness.
    • doi:10.1038/nrg1471.
    • Kitano H. Biological robustness. Nat Rev Genet 2005, 5:826-837. doi:10.1038/nrg1471.
    • (2005) Nat Rev Genet , vol.5 , pp. 826-837
    • Kitano, H.1
  • 81
    • 0036941857 scopus 로고    scopus 로고
    • Looking beyond the details: a rise in system-oriented approaches in genetics and molecular biology.
    • doi:10.1007/s00294-002-0285-z.
    • Kitano H. Looking beyond the details: a rise in system-oriented approaches in genetics and molecular biology. Curr Genet 2002, 41:1-10. doi:10.1007/s00294-002-0285-z.
    • (2002) Curr Genet , vol.41 , pp. 1-10
    • Kitano, H.1
  • 85
    • 55349111452 scopus 로고    scopus 로고
    • Complex networks: the key to systems biology.
    • doi:10.1590/S1415-47572008000400001.
    • da Fontoura Costa L, Rodrigues FA, Cristino AS. Complex networks: the key to systems biology. Genet Mol Biol 2008, 31:591-601. doi:10.1590/S1415-47572008000400001.
    • (2008) Genet Mol Biol , vol.31 , pp. 591-601
    • da Fontoura Costa, L.1    Rodrigues, F.A.2    Cristino, A.S.3
  • 89
    • 33645804842 scopus 로고    scopus 로고
    • A category theoretical argument against the possibility of artificial life: Robert Rosen's central proof revisited.
    • doi:10.1162/106454606775186392.
    • Chu D, Ho WK. A category theoretical argument against the possibility of artificial life: Robert Rosen's central proof revisited. Artif Life 2006, 12:117-134. doi:10.1162/106454606775186392.
    • (2006) Artif Life , vol.12 , pp. 117-134
    • Chu, D.1    Ho, W.K.2
  • 90
    • 34250695562 scopus 로고    scopus 로고
    • A living system must have noncomputable models.
    • doi:10.1162/artl.2007.13.3.293.
    • Louie AH. A living system must have noncomputable models. Artif Life 2007, 13:293-297. doi:10.1162/artl.2007.13.3.293.
    • (2007) Artif Life , vol.13 , pp. 293-297
    • Louie, A.H.1
  • 91
    • 0035905782 scopus 로고    scopus 로고
    • Modelling cellular behaviour.
    • doi:10.1038/35053181.
    • Endy D, Brent R. Modelling cellular behaviour. Nature 2001, 409:391-395. doi:10.1038/35053181.
    • (2001) Nature , vol.409 , pp. 391-395
    • Endy, D.1    Brent, R.2
  • 92
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart-from genes to cells to the whole organ.
    • doi:10.1126/science.1069881.
    • Noble D. Modeling the heart-from genes to cells to the whole organ. Science 2002, 295:1678-1682. doi:10.1126/science.1069881.
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 93
    • 0141596113 scopus 로고    scopus 로고
    • Molecular networks: the top-down view.
    • doi:10.1126/science. 1089118.
    • Bray D. Molecular networks: the top-down view. Science 2003, 301:1864-1865. doi:10.1126/science. 1089118.
    • (2003) Science , vol.301 , pp. 1864-1865
    • Bray, D.1
  • 95
    • 33745553265 scopus 로고    scopus 로고
    • Multi-scale methodology: a key to deciphering systems biology.
    • doi:10.2741/1590.
    • Ye X, Chu J, Zhuang Y, Zhang S. Multi-scale methodology: a key to deciphering systems biology. Front Biosci 2005, 10:961-965. doi:10.2741/1590.
    • (2005) Front Biosci , vol.10 , pp. 961-965
    • Ye, X.1    Chu, J.2    Zhuang, Y.3    Zhang, S.4
  • 97
    • 19344372443 scopus 로고    scopus 로고
    • Systems biology, integrative biology, predictive biology.
    • doi:10.1016/j.cell.2005.04.021.
    • Liu ET. Systems biology, integrative biology, predictive biology. Cell 2005, 121:505-506. doi:10.1016/j.cell.2005.04.021.
    • (2005) Cell , vol.121 , pp. 505-506
    • Liu, E.T.1
  • 98
    • 61349175175 scopus 로고    scopus 로고
    • From molecules to systems: the importance of looking both ways.
    • doi:10.1016/j.shpsc.2008.12.007.
    • Powell A, Dupré J. From molecules to systems: the importance of looking both ways. Stud Hist Philos Biol Biomed Sci 2009, 40:54-64. doi:10.1016/j.shpsc.2008.12.007.
    • (2009) Stud Hist Philos Biol Biomed Sci , vol.40 , pp. 54-64
    • Powell, A.1    Dupré, J.2
  • 100
    • 77951879100 scopus 로고    scopus 로고
    • Complementarity in biology. A reassessment in relation to molecular-reductionist and systemic approaches.
    • doi:10.1038/embor.2010.56.
    • Mazzocchi F. Complementarity in biology. A reassessment in relation to molecular-reductionist and systemic approaches. EMBO Rep 2010, 11:339-344. doi:10.1038/embor.2010.56.
    • (2010) EMBO Rep , vol.11 , pp. 339-344
    • Mazzocchi, F.1
  • 101
    • 34548804524 scopus 로고    scopus 로고
    • The next Step in biology: a periodic table.
    • doi:10.1007/s12038-007-0099-8.
    • Dhar PK. The next Step in biology: a periodic table. J Biosci 2007, 32:1005-1008. doi:10.1007/s12038-007-0099-8.
    • (2007) J Biosci , vol.32 , pp. 1005-1008
    • Dhar, P.K.1
  • 102
    • 77950366941 scopus 로고    scopus 로고
    • Ins and outs of systems biology vis-à-vis molecular biology: continuation or clear cut?
    • doi:10.1007/s10441-009-9089-6.
    • De Backer P, De Waele D, Van Speybroeck L. Ins and outs of systems biology vis-à-vis molecular biology: continuation or clear cut? Acta Biotheor 2010, 58:15-49. doi:10.1007/s10441-009-9089-6.
    • (2010) Acta Biotheor , vol.58 , pp. 15-49
    • De Backer, P.1    De Waele, D.2    Van Speybroeck, L.3
  • 104
    • 0002449777 scopus 로고    scopus 로고
    • Explaining emergence: towards an ontology of levels.
    • doi:10.1023/A:1008216127933.
    • Emmeche C, Køppe S, Stjernfelt F. Explaining emergence: towards an ontology of levels. J Gen Phil Sci 1997, 28:83-119. doi:10.1023/A:1008216127933.
    • (1997) J Gen Phil Sci , vol.28 , pp. 83-119
    • Emmeche, C.1    Køppe, S.2    Stjernfelt, F.3
  • 105
    • 53149135429 scopus 로고    scopus 로고
    • Making sense of emergence.
    • doi:10.1023/A:1004563122154.
    • Kim J. Making sense of emergence. Phil Stud 1999, 95:3-36. doi:10.1023/A:1004563122154.
    • (1999) Phil Stud , vol.95 , pp. 3-36
    • Kim, J.1
  • 106
    • 0002385995 scopus 로고
    • Downward causation in hierarchically organised biological systems.
    • eds. London: Macmillan;
    • Campbell DT. Downward causation in hierarchically organised biological systems. In: Ayala FJ, Dobzhansky T, eds. Studies in the Philosophy of Biology. London: Macmillan; 1974, 179-186.
    • (1974) Studies in the Philosophy of Biology. , pp. 179-186
    • Campbell, D.T.1    Ayala, F.J.2    Dobzhansky, T.3
  • 107
    • 77953539230 scopus 로고    scopus 로고
    • Ontological reduction and molecular structure.
    • doi:10.1016/j.shpsb.2010.03.005.
    • Hendry RF. Ontological reduction and molecular structure. Stud Hist Philos Sci 2010, 41:183-191. doi:10.1016/j.shpsb.2010.03.005.
    • (2010) Stud Hist Philos Sci , vol.41 , pp. 183-191
    • Hendry, R.F.1
  • 108
    • 0014604116 scopus 로고
    • A modified concept of consciousness.
    • doi:10.1037/h0028156.
    • Sperry RW. A modified concept of consciousness. Psychol Rev 1969, 76:532-536. doi:10.1037/h0028156.
    • (1969) Psychol Rev , vol.76 , pp. 532-536
    • Sperry, R.W.1
  • 109
    • 78751617193 scopus 로고    scopus 로고
    • On gene's action and reciprocal causation.
    • doi:10.1007/s10699-010-9199-2.
    • Perovic S, Miquel P-A. On gene's action and reciprocal causation. FoundSci 2011, 16:31-46. doi:10.1007/s10699-010-9199-2.
    • (2011) FoundSci , vol.16 , pp. 31-46
    • Perovic, S.1    Miquel, P.-A.2
  • 111
    • 0005030414 scopus 로고
    • New York: New York University Press;
    • Nagel E, Newman JR. Gödel's Proof. New York: New York University Press; 1958, 118.
    • (1958) Gödel's Proof. , pp. 118
    • Nagel, E.1    Newman, J.R.2
  • 116
    • 26444583165 scopus 로고    scopus 로고
    • What Is Complexity Science, Really?
    • doi:10.1207/S1532 7000EM0301_08.
    • Phelan SA. What Is Complexity Science, Really? Emergence 2001, 3:120-36. doi:10.1207/S1532 7000EM0301_08.
    • (2001) Emergence , vol.3 , pp. 120-136
    • Phelan, S.A.1
  • 118
    • 84859107078 scopus 로고    scopus 로고
    • Co-emergences in life and science: a double proposal for biological emergentism.
    • doi:10.1007/s11229-010-9725-3.
    • Damiano L. Co-emergences in life and science: a double proposal for biological emergentism. Synthese 2012, 185:273-294. doi:10.1007/s11229-010-9725-3.
    • (2012) Synthese , vol.185 , pp. 273-294
    • Damiano, L.1
  • 119
    • 1842363574 scopus 로고
    • The creative circle: sketches on the natural history of circularity.
    • ed. New York: Norton Publishing;
    • Varela FJ. The creative circle: sketches on the natural history of circularity. In: Watzlavick P, ed. The Invented Reality. New York: Norton Publishing; 1984, 309-323.
    • (1984) The Invented Reality. , pp. 309-323
    • Varela, F.J.1    Watzlavick, P.2
  • 121
    • 0003842881 scopus 로고
    • The tree of knowledge: the biological roots of human understanding. Shambhala.
    • Maturana H, Varela FJ. The tree of knowledge: the biological roots of human understanding. Shambhala. Boston 1987, 263.
    • (1987) Boston , pp. 263
    • Maturana, H.1    Varela, F.J.2
  • 122
    • 0037460094 scopus 로고    scopus 로고
    • Autopoietic and (M,R)-systems.
    • doi:10.1016/S0022-5193(03)00034-1.
    • Letelier JC, Marin J, Mpodozis J. Autopoietic and (M, R)-systems. J Theor Biol 2003, 222:261-272. doi:10.1016/S0022-5193(03)00034-1.
    • (2003) J Theor Biol , vol.222 , pp. 261-272
    • Letelier, J.C.1    Marin, J.2    Mpodozis, J.3
  • 123
  • 124
    • 70349145505 scopus 로고
    • New York: Columbia University Press;
    • Luhmann N. Essays on Self-Reference. New York: Columbia University Press; 1990, 245.
    • (1990) Essays on Self-Reference. , pp. 245
    • Luhmann, N.1
  • 125
    • 84873484962 scopus 로고    scopus 로고
    • Workshop on Reduction and Emergence. Ecole Normale Supérieure, Paris, 12-15 November. Available at:
    • Workshop on Reduction and Emergence. Ecole Normale Supérieure, Paris, 12-15 November 2003. Available at: http://www.institutnicod.org/reduction.htm.
    • (2003)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.