Filamins but not janus kinases are substrates of the asb2α cullin-ring e3 ubiquitin ligase in hematopoietic cells

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Lamsoul, Isabelle ^a,b   Erard, Monique ^a,b   van der Ven, Peter F M ^c   Lutz, Pierre G ^a,b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASB2ALPHA PROTEIN; FILAMIN; JANUS KINASE; JANUS KINASE 2; JANUS KINASE 3; MIXED LINEAGE LEUKEMIA PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL FUNCTIONS; CONTROLLED STUDY; ENZYME SUBSTRATE; ENZYME SUBUNIT; HEMATOPOIESIS; HEMATOPOIETIC CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURAL MODEL;

CELL LINE; CONTRACTILE PROTEINS; CULLIN PROTEINS; HUMANS; JANUS KINASES; LEUKEMIA, MYELOID, ACUTE; MICROFILAMENT PROTEINS; MICROSCOPY, FLUORESCENCE; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84865156877     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043798     Document Type: Article

References (20)

1. Heuze ML, Guibal FC, Banks CA, Conaway JW, Conaway RC, et al. ((2005)) ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex. J Biol Chem 280: 5468-5474.
2. Kohroki J, Nishiyama T, Nakamura T, Masuho Y, ((2005)) ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. FEBS Lett 579: 6796-6802.
3. Bello NF, Lamsoul I, Heuze ML, Metais A, Moreaux G, et al. ((2009)) The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Cell Death Differ 16: 921-932.
4. Okumura F, Matsuzaki M, Nakatsukasa K, Kamura T, ((2012)) The Role of Elongin BC-Containing Ubiquitin Ligases. Front Oncol 2: 10.
5. Guibal FC, Moog-Lutz C, Smolewski P, Di Gioia Y, Darzynkiewicz Z, et al. ((2002)) ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells. J Biol Chem 277: 218-224.
6. Heuze ML, Lamsoul I, Baldassarre M, Lad Y, Leveque S, et al. ((2008)) ASB2 targets filamins A and B to proteasomal degradation. Blood 112: 5130-5140.
7. Kohroki J, Fujita S, Itoh N, Yamada Y, Imai H, et al. ((2001)) ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells. FEBS Lett 505: 223-228.
8. Moog-Lutz C, Cave-Riant F, Guibal FC, Breau MA, Di Gioia Y, et al. ((2003)) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood 102: 3371-3378.
9. Martens JH, Brinkman AB, Simmer F, Francoijs KJ, Nebbioso A, et al. ((2010)) PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia. Cancer Cell 17: 173-185.
10. Spicuglia S, Vincent-Fabert C, Benoukraf T, Tiberi G, Saurin AJ, et al. ((2011)) Characterisation of Genome-Wide PLZF/RARA Target Genes. PLoS One 6: e24176.
11. Schenk T, Chen WC, Gollner S, Howell L, Jin L, et al. ((2012)) Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 18: 605-611.
12. Burande CF, Heuze ML, Lamsoul I, Monsarrat B, Uttenweiler-Joseph S, et al. ((2009)) A label-free quantitative proteomics strategy to identify E3 ubiquitin ligase substrates targeted to proteasome degradation. Mol Cell Proteomics 8: 1719-1727.
13. Lamsoul I, Burande CF, Razinia Z, Houles TC, Menoret D, et al. ((2011)) Functional and Structural Insights into ASB2α, a Novel Regulator of Integrin-dependent Adhesion of Hematopoietic Cells. J Biol Chem 286: 30571-30581.
14. Wang J, Muntean AG, Hess JL, ((2012)) ECSASB2 mediates MLL degradation during hematopoietic differentiation. Blood 119: 1151-1161.
15. Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, et al. ((2011)) Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res 21: 754-769.
16. Wu W, Sun XH, ((2011)) A Mechanism Underlying NOTCH-Induced and Ubiquitin-mediated JAK3 Degradation. J Biol Chem 286: 41153-41162.
17. Biethahn S, Alves F, Wilde S, Hiddemann W, Spiekermann K, ((1999)) Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia. Exp Hematol 27: 885-894.
18. Michaely P, Tomchick DR, Machius M, Anderson RG, ((2002)) Crystal structure of a 12 ANK repeat stack from human ankyrinR. Embo J 21: 6387-6396.
19. Bullock AN, Debreczeni JE, Edwards AM, Sundstrom M, Knapp S, ((2006)) Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc Natl Acad Sci U S A 103: 7637-7642.
20. Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, et al. ((2002)) Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 416: 703-709.