Selected chromone derivatives as inhibitors of monoamine oxidase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5480-5484

  Legoabe, Lesetja J ^a   Petzer, Anél ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Benzopyran 4 one; Chromone; MAO B; Monoamine oxidase; Reversible inhibition; Structure activity relationships

Indexed keywords

2 HYDROXY 2,3 DIHYDRO 1 BENZOPYRAN 4 ONE DERIVATIVE; 6 [(3 BROMOBENZYL)OXY]CHROMONE; 6 [(3 BROMOBENZYL)OXYL] 4H CHROMEN 4 ONE; CHROMONE 3 CARBOXYLIC ACID; CHROMONE DERIVATIVE; MONOAMINE OXIDASE INHIBITOR; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION;

BENZOPYRANS; CHROMONES; HUMANS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865150531     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.025     Document Type: Article

References (20)

1. M.B.H. Youdim, and Y.S. Bakhle Br. J. Pharmacol. 147 2006 S287
2. M.B.H. Youdim, D. Edmondson, and K.F. Tipton Nat. Rev. Neurosci. 7 2006 295
3. D.A. Di Monte, L.E. DeLanney, I. Irwin, J.E. Royland, P. Chan, M.W. Jakowec, and J.W. Langston Brain Res. 738 1996 53
4. J.P. Finberg, J. Wang, K. Bankiewich, J. Harvey-White, I.J. Kopin, and D.S. Goldstein J. Neural Transm. Suppl. 52 1998 279
5. S. Menazza, B. Blaauw, T. Tiepolo, L. Toniolo, P. Braghetta, B. Spolaore, C. Reggiani, F. Di Lisa, P. Bonaldo, and M. Canton Hum. Mol. Genet. 19 2010 4207
6. E. Trouche, C. Mias, M.H. Seguelas, C. Ordener, D. Cussac, and A. Parini Stem Cells Dev. 19 2010 1571
7. J.S. Fowler, N.D. Volkow, G.J. Wang, J. Logan, N. Pappas, C. Shea, and R. MacGregor Neurobiol. Aging. 18 1997 431
8. C. Gnerre, M. Catto, F. Leonetti, P. Weber, P.-A. Carrupt, C. Altomare, A. Carotti, and B. Testa J. Med. Chem. 43 2000 4747
9. A. Gaspar, T. Silva, M. Yáñez, D. Viña, F. Orallo, F. Ortuso, E. Uriarte, S. Alcaro, and F. Borges J. Med. Chem. 54 2011 5165
10. A. Gaspar, J. Reis, A. Fonseca, N. Milhazes, D. Viña, E. Uriarte, and F. Borges Bioorg. Med. Chem. Lett. 21 2011 707
11. S. Alcaro, A. Gaspar, F. Ortuso, N. Milhazes, F. Orallo, E. Uriarte, M. Yáñez, and F. Borges Bioorg. Med. Chem. Lett. 20 2010 2709
12. L.J. Legoabe, A. Petzer, and J.P. Petzer Eur. J. Med. Chem. 49 2012 343
13. T.A. Zesiewicz, and R.A. Hauser S.A. Factor, W.J. Weiner, Parkinson's disease: diagnosis and clinical management 2002 Demos Medical Publishing New York 365 378
14. Legoabe, L. J.; Petzer, A.; Petzer, J. P., in preparation.
15. N. Ishizuka, K. Matsumura, K. Sakai, M. Fujimoto, S. Mihara, and T. Yamamori J. Med. Chem. 45 2002 2041
16. A. Schonberg, and A. Sina J. Am. Chem. Soc. 72 1950 3396
17. L. Novaroli, M. Reist, E. Favre, A. Carotti, M. Catto, and P.A. Carrupt Bioorg. Med. Chem. 13 2005 6212
18. B. Strydom, S.F. Malan, N. Castagnoli, J.J. Bergh, and J.P. Petzer Bioorg. Med. Chem. 18 2010 1018
19. D. Secci, S. Carradori, A. Bolasco, P. Chimenti, M. Yáñez, F. Ortuso, and S. Alcaro Eur. J. Med. Chem. 46 2011 4846
20. F. Chimenti, D. Secci, A. Bolasco, P. Chimenti, B. Bizzarri, A. Granese, S. Carradori, M. Yáñez, F. Orallo, F. Ortuso, and S. Alcaro J. Med. Chem. 2009 1935 52