The sense strand pre-cleaved RNA duplex mediates an efficient RNA interference with less off-target and immune response effects

Applied Microbiology and Biotechnology

Volumn 90, Issue 2, 2011, Pages 583-589

  Lu, Xiaozhao ^a   Yang, Guodong ^a   Zhang, Jie ^a   Fu, Haiyan ^a   Jin, Liang ^a   Wei, Mengying ^a   Wang, Li ^a   Lu, Zifan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Immune response; Off target effects; RNAi

Indexed keywords

ANTISENSE; FUTURE APPLICATIONS; IMMUNE RESPONSE; LUCIFERASE ACTIVITIES; NF-KAPPAB; NOVEL METHODS; NOVEL STRATEGIES; OFF-TARGET EFFECTS; RNA DUPLEXES; RNA INTERFERENCE; RNA SILENCING; RNAI; TARGET SEQUENCES;

ENZYME ACTIVITY; IMMUNOLOGY; PLANTS (BOTANY); RNA;

NUCLEIC ACIDS;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; RNA; SMALL INTERFERING RNA;

CANCER; DISEASE TREATMENT; ENZYME ACTIVITY; IMMUNE RESPONSE; INHIBITION; RNA;

ARTICLE; ENZYME ACTIVITY; GENE SILENCING; IMMUNE RESPONSE; REPORTER GENE; RNA INTERFERENCE; RNA SEQUENCE; RNA STRUCTURE;

CELLS, CULTURED; GENE KNOCKDOWN TECHNIQUES; HT29 CELLS; HUMANS; IMMUNITY; NF-KAPPA B; RNA; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 79954713173     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-3065-6     Document Type: Article

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