Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1722-1726

  Efthymiou, Tim C ^a   Huynh, Vanthi ^a   Oentoro, Jaymie ^a   Peel, Brandon ^a   Desaulniers, Jean Paul ^a  

^a UNIVERSITY OF ONTARIO INSTITUTE OF TECHNOLOGY   (Canada)

Author keywords

Gene silencing; Huisgen dipolar cycloaddition; Modified nucleoside; Short interfering RNA; Triazole linkage

Indexed keywords

FIREFLY LUCIFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PHOSPHORIC ACID DERIVATIVE; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; TRIAZOLE DERIVATIVE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CHEMISTRY; CLICK CHEMISTRY; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; RNA ANALYSIS; RNA INTERFERENCE; THERMODYNAMICS;

EID: 84856683514     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.104     Document Type: Article

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