Combined effect of sCD40L and PI3K siRNA on transplanted tumours growth and microenvironment in nude mice with gastric cancer

Molecular Biology Reports

Volumn 39, Issue 9, 2012, Pages 8755-8761

  Li, Rui ^a   Chen, Wei Chang ^a   Pang, Xue Qin ^a   Tian, Wen Yan ^a   Wang, Wei Peng ^a   Zhang, Xue Guang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Antitumour; Gastric cancer; Nude mice; PI3K siRNA; SCD40L

Indexed keywords

CD40 LIGAND; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; SURVIVIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; GENE SILENCING; IMMUNOHISTOCHEMISTRY; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RNA DEGRADATION; RNA INTERFERENCE; STOMACH CANCER; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR VOLUME; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CD40 LIGAND; FEMALE; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASE; REPRESSOR PROTEINS; RNA INTERFERENCE; STOMACH NEOPLASMS; TUMOR BURDEN; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 84865135658     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1736-3     Document Type: Article

References (41)

1. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501 (Pubitemid 37328931)
2. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ (2005) RAS is regulated by the let-7 microRNA family. Cell 120(5):635-647 (Pubitemid 40343076)
3. Dvorak HF, Brown LF, Detmar M, Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146:1029-1039
4. O'Grady A, O'Kelly P, Murphy GM, Leader M, Kay E (2004) COX-2 expression correlates with microvessel density in non-melanoma skin cancer from renal transplant recipients and immunocompetent individuals. Hum Pathol 35(12):1549-1555 (Pubitemid 40017997)
5. Smyth SS, Patterson C (2002) Tiny dancers: the integrin-growth factor nexus in angiogenic signaling. J Cell Biol 158:17-21
6. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294(5543):853-858 (Pubitemid 33032103)
7. Brodersen P, Voinnet O (2009) Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 10(2):141-148
8. Abulafia O, Sherer DM (1999) Angiogenesis of the endometrium. Obstet Gynecol 94:148-153 (Pubitemid 29284446)
9. Altieri DC (2006) The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr Opin Cell Biol 18:609-615 (Pubitemid 44692469)
10. Miyachi K, Sasaki K, Onodera S, Taguchi T, Nagamachi M, Kaneko H, Sunagawa M (2003) Correlation between survivin mRNA expression and lymph node metastasis in gastric cancer. Gastric Cancer 6:217-224 (Pubitemid 38140003)
11. Lu CD, Altieri DC, Tanigawa N (1998) Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res 58:1808
12. Song JZ, Su BZ, Li TM (2007) Expression of survivin gene in gastric ulcer and gastric cancer. Inn Mong Med J 39:4-7
13. Croce CM (2009) Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10(10):704-714
14. Dunn GP, Old LJ, Schreiber RD (2004) The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21:137-148 (Pubitemid 39094044)
15. Guo JF, Bourre L, Soden DM, O'Sullivan GC, O'Driscoll C (2011) Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics? Biotechnol Adv 29:402-417
16. Wakana Y, Kasuya K, Katayanagi S, Tsuchida A, Aoki T, Koyanagi Y, Ishii H, Ebihara Y (2002) Effect of survivin on cell proliferation and apoptosis in gastric cancer. Oncol Rep 9:1213
17. De Vita F, Giuliani F, Silvestris N, Catalano G, Ciardiello F, Orditura M (2010) Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target. Cancer Treat Rev 36S3:S11-S15
18. Panani AD (2008) Cytogenetic and molecular aspects of gastric cancer: clinical implications. Cancer Lett 266:99-115
19. Parkin DM, Laara E, Muir CS (1988) Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41:184-197 (Pubitemid 18061141)
20. Lin X, Bohle AS, Dohrmann P, Leuschner I, Schulz A, Kremer B, Fandrich F (2001) Overexpression of phosphatidylinositol 3-kinase in human lung cancer. Langenbecks Arch Surg 386:293-301 (Pubitemid 32702759)
21. Oh Y-K, Park TG (2009) siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 61:850-862
22. Migheli A, Mongini T, Doriguzzi C, Chiadò-Piat L, Piva R, Ugo I, Palmucci L (1997) Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease. Neurogenetics 1:81-87 (Pubitemid 127709613)
23. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133(2):647-658 (Pubitemid 47187346)
24. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nat Med 1:27-31
25. Ang KL, Shi DL, Keong WW, Epstein RJ (2005) Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention. Cancer Lett 225:53-59 (Pubitemid 40732768)
26. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70 (Pubitemid 30046295)
27. Fry MJ (2001) Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? Breast Cancer Res 3:304-312 (Pubitemid 32851160)
28. Karpeh M, Kelsen D, Tepper J (2001) Cancer of the stomach. In: DeVita V, Hellman S, Rosenberg S (eds) Cancer: principles and practice of oncology. Lippincott Williams and Wilkins, Philadelphia, pp 1092-1126
29. Spaulding B, Pan D, Ghadersohi A, Nielsen G, Jensen S, Gellert F, Ling X, Zhang M, Black A, Li F (2006) Characterization of the 12C4 survivin monoclonal antibody and insight into the expression of survivin in human adult tissues. Histopathology 49:622-633 (Pubitemid 44924294)
30. Ferrara N (1995) The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat 36:127-137
31. Kania J, Konturek SJ, Marlicz K, Hahn EG, Konturek PC (2003) Expression of survivin and caspase-3 in gastric cancer. Dig Dis Sci 48:266 (Pubitemid 36232990)
32. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4:988-1004
33. Jucker M, Sudel K, Horn S, Sickel M, Wegner W, Fiedler W, Feldman RA (2002) Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO). Leukemia 16:894-901 (Pubitemid 34537563)
34. Krasilnikov M, Adler V, Fuchs SY, Dong Z, Haimovitz-Friedman A, Herlyn M, Ronai Z (1999) Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells. Mol Carcinog 24:64-69 (Pubitemid 29070245)
35. Ekstrom AM, Held M, Hansson LE, Engstrand L, Nyren O (2001) Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology 121:784-791 (Pubitemid 32959388)
36. Van't Veer LJ, Weigelt B (2003) Road map to metastasis. Nat Med 9:999-1000 (Pubitemid 37021777)
37. Akhtar S, Benter IF (2007) Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 117:3623-3632 (Pubitemid 350224068)
38. Kami K, Doi R, Koizumi M, Toyoda E, Mori T, Ito D, Kawaguchi Y, Fujimoto K, Wada M, Miyatake S, Imamura M (2005) Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells. Surgery 138:299-305 (Pubitemid 41253814)
39. Hood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA (2003) Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J Cell Biol 162:933-943 (Pubitemid 37087732)
40. Frontczak-Baniewicz M, Walski M, Sulejczak D (2007) Diversity of immunophenotypes of endothelial cells participating in new vessel formation following surgical rat brain injury. J Physiol Pharmacol 58(Suppl 5):193-203 (Pubitemid 351346667)
41. Yoon SO, Shin S, Lee HJ, Chun HK, Chung AS (2006) Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther 5:2666-2675 (Pubitemid 44848993)