Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells

Neuroendocrinology

Volumn 91, Issue 2, 2010, Pages 200-210

  Schaaf, Christian ^a,c   Shan, Bing ^a   Onofri, Chiara ^a   Stalla, Günter K ^a   Arzt, Eduardo ^b   Schilling, Tobias ^c   Perone, Marcelo J ^b   Renner, Ulrich ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b INSTITUTO DE FISIOLOGÍA   (Argentina)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; Cell cycle; Curcumin; Folliculostellate pituitary cells; Interleukin 6; Nuclear factor B; Proliferation; Tlr4; Vascular endothelial growth factor

Indexed keywords

7 AMINODACTINOMYCIN; AGAR; CASPASE 3; CURCUMIN; CYCLIN D1; DNA; ENDOTOXIN; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOCORTIN 5; MESSENGER RNA; PROTEIN BCL 2; TOLL LIKE RECEPTOR 4; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL TYPE; COLONY FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA FRAGMENTATION; DRUG INHIBITION; ENDOCRINE CELL; FLUORESCENCE ACTIVATED CELL SORTING; GROWTH INHIBITION; HYPOPHYSIS CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MONOLAYER CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PITUITARY FOLLICULOSTELLATE CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CURCUMIN; INTERLEUKIN-6; MALE; MICE; PITUITARY GLAND, ANTERIOR; PITUITARY NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77949918700     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000287236     Document Type: Article

References (50)

1. Rinehart JF, Farquhar MG: Electron microscopic studies of the anterior pituitary gland. J Histochem Cytochem 1953; 1: 93-113.
2. Inoue K, Couch EF, Takano K, Ogawa S: The structure and function of folliculo-stellate cells in the anterior pituitary gland. Arch Histol Cytol 1999; 62: 205-218.
3. Allaerts W, Vankelecom H: History and perspectives of pituitary folliculo-stellate cell research. Eur J Endocrinol 2005; 153: 1-12.
4. Fauquier T, Guerineau NC, McKinney RA, Bauer K, Mollard P: Folliculostellate cell network: a route for long-distance communication in the anterior pituitary. Proc Natl Acad Sci USA 2001; 98: 8891-8896.
5. Fauquier T, Lacampagne A, Travo P, Bauer K, Mollard P: Hidden face of the anterior pituitary. Trends Endocrinol Metab 2002: 13; 304-309.
6. Morand I, Fonlupt P, Guerrier A, Trouillas J, Calle A, Remy C, Rousset B, Munari-Silem Y: Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and folliculostellate cells. Endocrinology 1996; 137: 3356-3367.
7. Lewis BM, Pexa A, Francis K, Verma V, Mc- Nicol AM, Scanlon M, Deussen A, Evans WH, Rees A, Ham J: Adenosine stimulates connexin 43 expression and gap junctional communication in pituitary folliculostellate cells. FASEB J 2006; 20: 2585-2587.
8. Meilleur MA, Akpovi CD, Pelletier RM, Vitale ML: Tumor necrosis factor-α -induced anterior pituitary folliculostellate TtT/GF cell uncoupling is mediated by connexin 43 dephosphorylation. Endocrinology 2007; 148: 5913-5924.
9. Aoki A, de Gaisan EO, Pasolli HA, Torres AI: Disposal of cell debris from surplus lactotrophs of pituitary gland. Exp Clin Endocrinol Diabetes 1996; 104: 256-262.
10. Luziga C, Yamamoto Y, Horii Y, Mbassa G, Mamba K: Phagocytotic removal of apoptotic endocrine cells by folliculostellate cells and its functional implications in clusterin accumulation in pituitary colloids in helmeted guinea fowl (Numida meleagris). Acta Histochem 2006; 108: 69-80.
11. Allaerts W, Jeucken PHM, Debets R, Hoefakker S, Claassen E, Drexhage HA: Heterogeneity of pituitary folliculo-stellate cells: implications for IL-6 production and accessory function in vitro. J Neuroendocrinol 1997; 9: 43-53.
12. Fauquier T, Rizzoti K, Dattani M, Lovell- Bage R, Robinson IC: SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci USA 2008; 105: 2907-2912.
13. Gospodarowicz D, Abraham JA, Schilling J: Isolation and characterization of a vascular cell mitogen produced by pituitary-derived folliculostellate cells. Proc Natl Acad Sci USA 1989; 6: 7311-7315.
14. Vankelecom H, Carmeliet P, Van Damme J, Billiau A, Denef C: Production of interleukin-6 by folliculo-stellate cells of the anterior pituitary gland in a histiotypic cell aggregate culture system. Neuroendocrinology 1989; 49: 102-106.
15. Renner U, De Santana EC, Gerez J, Fröhlich B, Haedo M, Pereda MP, Onofri C, Stalla GK, Arzt E: Intrapituitary expression and regulation of the gp130 cytokine interleukin-6 and its implication in pituitary physiology and pathophysiology. Ann N Y Acad Sci 2009; 1153: 89-97.
16. Ferrara N: Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611.
17. Lohrer P, Gloddek J, Nagashima AC, Korali Z, Hopfner U, Pereda MP, Arzt E, Stalla GK, Renner U: Lipopolysaccharide directly stimulates the intrapituitary interleukin-6 production by folliculostellate cells via specific receptors and the p38α mitogen-activated protein kinase/nuclear factor-κB pathway. Endocrinology 2000; 141: 4457-4465.
18. Gloddek J, Lohrer P, Stalla J, Arzt E, Stalla GK, Renner U: The intrapituitary stimulatory effect of lipopolysaccharide on ACTH secretion is mediated by paracrine-acting IL-6. Exp Clin Endocrinol Diabetes 2001; 109: 410-415.
19. Aggarwal BB, Sundaram C, Malani N, Ichikawa H: Curcumin: the Indian solid gold. Adv Exp Med Biol 2007; 595: 1-75.
20. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV: Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 2008; 65: 1631-1652.
21. Shishodia S, Chaturvedi MM, Aggarwal BB: Role of curcumin in cancer therapy. Current Probl Cancer 2007; 31: 243-305.
22. Singh S: From exotic spice to modern drug? Cell 2007; 130: 765-768.
23. Sa G, Das T: Anti cancer effects of curcumin: cycle of life and death. Cell Div 2008; 3: 1-14.
24. Shankar S, Ganapathy S, Chen Q, Srivastava RK: Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Mol Cancer 2008; 7: 16.
25. Corson TW, Crews CM: Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 2007; 130: 769-774.
26. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008; 14: 4491-4499.
27. Johnson JJ, Mukhtar H: Curcumin for chemoprevention of colon cancer. Cancer Lett 2007; 255: 170-181.
28. Kunnumakkara AB, Anand P, Aggarwal BB: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signalling proteins. Cancer Lett 2008; 269: 199-225.
29. Carroll CE, Ellersieck MR, Hyder SM: Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells. Menopause 2008; 15: 570-574.
30. Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, Li X, Safe S: Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 2008; 68: 5345-5354.
31. Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB: Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic Biol Med 2007; 43: 568-580.
32. Miller M, Chen S, Woodliff J, Kansra S: Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells. Endocrinology 2008; 149: 4158-4167.
33. Inoue K, Matsumoto H, Koyama C, Shibata K, Nakazato Y, Ito A: Establishment of a folliculostellate- like cell line from a murine thyrotropic pituitary tumor. Endocrinology 1992; 131: 3110-3116.
34. Renner U, Newton CJ, Pagotto U, Sauer J, Arzt E, Stalla GK: Involvement of interleukin-1 and interleukin-1 receptor antagonist in rat pituitary cell growth regulation. Endocrinology 1995; 136: 3186-3193.
35. Onofri C, Theodoropoulou M, Losa M, Uhl E, Lange M, Arzt E, Stalla GK, Renner U: Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumors. J Endocrinol 2006; 191: 249-261.
36. Nolan LA, Kavanagh E, Lightman SL, Levy A: Anterior pituitary cell population control: basal turnover and the effects of adrenalectomy and dexamethasone treatment. J Neuroendocrinol 1998; 10: 207-215.
37. Levy A: Physiological implications of pituitary trophic activity. J Endocrinol 2002; 174: 147-155.
38. Besedovsky HO, del Rey A: Immune-neuroendocrine interactions: facts and hypotheses. Endocr Rev 1996; 17: 64-102.
39. Herkenham M: Folliculo-stellate (FS) cells of the anterior pituitary mediate interactions between the endocrine and immune systems. Endocrinology 2005; 146: 33-34.
40. Gautam SC, Gao X, Dulchavsky S: Immunomodulation by curcumin. Adv Exp Med Biol 2007; 595: 321-341.
41. Lubbad A, Oriowo MA, Kahn I: Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Mol Cell Biochem 2009; 322: 127-135.
42. Harper SJ, Bates DO: VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008; 8: 880-887.
43. Jabbour HN, Boddy SC, Lincoln GA: Pattern of localisation of expression of vascular endothelial growth factor and its receptor flt-1 in the ovine pituitary gland: expression is independent of hypothalamic control. Mol Cell Endocrinol 1997; 134: 91-100.
44. Arzt E, Buric R, Stelzer G, Stalla J, Sauer J, Renner U, Stalla GK: Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology 1993; 132: 459-467.
45. Hori S, Hayashi N, Fukuoda J, Kurimoto M, Hamada H, Miyajima K, Nagai S, Endo S: Folliculostellate cell tumor in the pituitary gland. Neuropathology 2009; 29: 78-80.
46. Roncaroli F, Scheithauer BW, Cenacchi G, Horvath E, Kovacs K, Lloyd RV, Abell-Aleff P, Santi M, Yates AJ: 'Spindle cell oncocytoma' of the adenohypophysis. A tumor of folliculostellate cells? Am J Surg Pathol 2002; 26: 1048-1055.
47. Iwaki T, Kondo A, Takeshita I, Nakagaki H, Kitamura K, Tateishi J: Proliferating potential of folliculo-stellate cells in human pituitary adenomas. Immunohistochemical and electron microscopic analysis. Acta Neuropathol 1986; 71: 233-242.
48. Höfler H, Walter GF, Denk H: Immunohistochemistry of folliculo-stellate cells in normal human adenohypopheses and in pituitary adenomas. Acta Neuropathol 1984; 65: 35-40.
49. Farnoud MR, Kujas M, Derome P, Racadot J, Peillon F, Li JY: Interactions between normal and tumoral tissues at the boundary of human pituitary adenomas. Virchows Arch 1994; 424: 75-82.
50. Yamashita M, Qian ZR, Sano T, Horvath E, Kovacs K: Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis. Pathol Int 2005; 55: 244-247.