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Volumn 86, Issue 16, 2012, Pages 8422-8431

Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYNUCLEOSIDE TRIPHOSPHATE; EMTRICITABINE; LAMIVUDINE; NUCLEOSIDE TRIPHOSPHATE; PROTEIN P51; PROTEIN P66; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

EID: 84865099478     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00271-12     Document Type: Article
Times cited : (17)

References (57)
  • 1
    • 9644291579 scopus 로고    scopus 로고
    • TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1
    • Andries K, et al. 2004. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 48:4680-4686.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 4680-4686
    • Andries, K.1
  • 2
    • 0028176053 scopus 로고
    • Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction
    • Arts EJ, et al. 1994. Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. J. Biol. Chem. 269:14672-14680.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14672-14680
    • Arts, E.J.1
  • 3
    • 78751693611 scopus 로고    scopus 로고
    • Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes
    • Asahchop EL, et al. 2011. Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes. Antimicrob. Agents Chemother. 55:600-607.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 600-607
    • Asahchop, E.L.1
  • 4
    • 75749118495 scopus 로고    scopus 로고
    • TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTIresistant HIV-1
    • Azijn H, et al. 2010. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTIresistant HIV-1. Antimicrob. Agents Chemother. 54:718-727.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 718-727
    • Azijn, H.1
  • 5
    • 0030691001 scopus 로고    scopus 로고
    • Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptase
    • Back NK, Berkhout B. 1997. Limiting deoxynucleoside triphosphate concentrations emphasize the processivity defect of lamivudine-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 41:2484-2491.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2484-2491
    • Back, N.K.1    Berkhout, B.2
  • 6
    • 0029757751 scopus 로고    scopus 로고
    • Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme
    • Back NK, et al. 1996. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J. 15:4040-4049.
    • (1996) EMBO J , vol.15 , pp. 4040-4049
    • Back, N.K.1
  • 7
    • 0034990846 scopus 로고    scopus 로고
    • Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV
    • Balzarini J, et al. 2001. Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. J. Virol. 75:5772-5777.
    • (2001) J. Virol. , vol.75 , pp. 5772-5777
    • Balzarini, J.1
  • 8
    • 0028068907 scopus 로고
    • Sensitivity of (138 Glu¡Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors
    • Balzarini J, et al. 1994. Sensitivity of (138 Glu¡Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors. Biochem. Biophys. Res. Commun. 201: 1305-1312.
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 1305-1312
    • Balzarini, J.1
  • 9
    • 12144273186 scopus 로고    scopus 로고
    • The antiretroviral rollout and drug-resistant HIV in Africa, insights from empirical data and theoretical models
    • Blower S, Bodine E, Kahn J, McFarland W. 2005. The antiretroviral rollout and drug-resistant HIV in Africa: insights from empirical data and theoretical models. AIDS 19:1-14.
    • (2005) AIDS , vol.19 , pp. 1-14
    • Blower, S.1    Bodine, E.2    Kahn, J.3    McFarland, W.4
  • 10
  • 11
    • 0028024028 scopus 로고
    • Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase
    • Boyer PL, Ding J, Arnold E, Hughes SH. 1994. Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 38:1909-1914.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 1909-1914
    • Boyer, P.L.1    Ding, J.2    Arnold, E.3    Hughes, S.H.4
  • 12
    • 79951488119 scopus 로고    scopus 로고
    • Increased detection of the HIV-1 reverse transcriptase M184V mutation using mutation-specific minority assays in aUK surveillance study suggests evidence of unrecognized transmitted drug resistance
    • Buckton AJ, et al. 2011. Increased detection of the HIV-1 reverse transcriptase M184V mutation using mutation-specific minority assays in aUK surveillance study suggests evidence of unrecognized transmitted drug resistance. HIV Med. 12:250-254.
    • (2011) HIV Med , vol.12 , pp. 250-254
    • Buckton, A.J.1
  • 14
    • 0037974512 scopus 로고    scopus 로고
    • The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates
    • Diallo K, et al. 2003. The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates. Antimicrob. Agents Chemother. 47:2376-2379.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2376-2379
    • Diallo, K.1
  • 15
    • 0242354002 scopus 로고    scopus 로고
    • Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase
    • Diallo K, Gotte M, Wainberg MA. 2003. Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 47:3377-3383.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 3377-3383
    • Diallo, K.1    Gotte, M.2    Wainberg, M.A.3
  • 16
    • 19944379446 scopus 로고    scopus 로고
    • Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase
    • Diamond TL, et al. 2004. Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J. Biol. Chem. 279:51545-51553.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51545-51553
    • Diamond, T.L.1
  • 17
    • 0030935265 scopus 로고    scopus 로고
    • Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor
    • Esnouf RM, et al. 1997. Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Proc. Natl. Acad. Sci. U. S. A. 94:3984-3989.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 3984-3989
    • Esnouf, R.M.1
  • 18
    • 44049093742 scopus 로고    scopus 로고
    • Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect
    • Gao L, et al. 2008. Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect. J. Biol. Chem. 283:9196-9205.
    • (2008) J. Biol. Chem. , vol.283 , pp. 9196-9205
    • Gao, L.1
  • 19
    • 0024999452 scopus 로고
    • Retroviral reverse transcriptase, synthesis, structure, and function
    • Goff SP. 1990. Retroviral reverse transcriptase: synthesis, structure, and function. J. Acquir. Immune Defic. Syndr. 3:817-831.
    • (1990) J. Acquir. Immune Defic. Syndr. , vol.3 , pp. 817-831
    • Goff, S.P.1
  • 20
    • 0026318332 scopus 로고
    • Reconstitution and properties of homologous and chimeric HIV-1 HIV-2 p66. p51 reverse transcriptase
    • Howard KJ, Frank KB, Sim IS, Le Grice SF. 1991. Reconstitution and properties of homologous and chimeric HIV-1.HIV-2 p66.p51 reverse transcriptase.J. Biol. Chem. 266:23003-23009.
    • (1991) J. Biol. Chem. , vol.266 , pp. 23003-23009
    • Howard, K.J.1    Frank, K.B.2    Sim, I.S.3    Le Grice, S.F.4
  • 21
    • 80055103177 scopus 로고    scopus 로고
    • Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine, effects on fitness and RT activity of human immunodeficiency virus type 1
    • Hu Z, Kuritzkes DR. 2011. Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine: effects on fitness and RT activity of human immunodeficiency virus type 1. J. Virol. 85:11309-11314.
    • (2011) J. Virol. , vol.85 , pp. 11309-11314
    • Hu, Z.1    Kuritzkes, D.R.2
  • 22
    • 0037223722 scopus 로고    scopus 로고
    • Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication
    • Huang W, Gamarnik A, Limoli K, Petropoulos CJ, Whitcomb JM. 2003. Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication. J. Virol. 77:1512-1523.
    • (2003) J. Virol. , vol.77 , pp. 1512-1523
    • Huang, W.1    Gamarnik, A.2    Limoli, K.3    Petropoulos, C.J.4    Whitcomb, J.M.5
  • 23
    • 0034469498 scopus 로고    scopus 로고
    • Relative replication fitness of a high-level 3=-azido-3=-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr¡Gly) at codon 69
    • Imamichi T, et al. 2000. Relative replication fitness of a high-level 3=-azido-3=-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr¡Gly) at codon 69. J. Virol. 74:10958-10964.
    • (2000) J. Virol. , vol.74 , pp. 10958-10964
    • Imamichi, T.1
  • 24
    • 44049098457 scopus 로고    scopus 로고
    • Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage
    • Jamburuthugoda VK, et al. 2008. Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage. J. Biol. Chem. 283:9206-9216.
    • (2008) J. Biol. Chem. , vol.283 , pp. 9206-9216
    • Jamburuthugoda, V.K.1
  • 25
    • 20144372481 scopus 로고    scopus 로고
    • In search of a novel anti-HIV drug, multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine)
    • Janssen PA, et al. 2005. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). J. Med. Chem. 48:1901-1909.
    • (2005) J. Med. Chem. , vol.48 , pp. 1901-1909
    • Janssen, P.A.1
  • 26
    • 84859231900 scopus 로고    scopus 로고
    • 2011 update of the drug resistance mutations in HIV-1
    • Johnson VA, et al. 2011. 2011 update of the drug resistance mutations in HIV-1. Top. Antivir. Med. 19:156-164.
    • (2011) Top. Antivir. Med. , vol.19 , pp. 156-164
    • Johnson, V.A.1
  • 27
    • 0031717603 scopus 로고    scopus 로고
    • Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate
    • Julias JG, Pathak VK. 1998. Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate. J. Virol. 72:7941-7949.
    • (1998) J. Virol. , vol.72 , pp. 7941-7949
    • Julias, J.G.1    Pathak, V.K.2
  • 29
    • 0030896362 scopus 로고    scopus 로고
    • Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase
    • Keulen W, Back NK, van Wijk A, Boucher CA, Berkhout B. 1997. Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase. J. Virol. 71:3346-3350.
    • (1997) J. Virol. , vol.71 , pp. 3346-3350
    • Keulen, W.1    Back, N.K.2    van Wijk, A.3    Boucher, C.A.4    Berkhout, B.5
  • 30
    • 0026693137 scopus 로고
    • Crystal structure at 3 5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. 1992. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-1790.
    • (1992) Science , vol.256 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 31
    • 83655201316 scopus 로고    scopus 로고
    • The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness
    • Kulkarni R, et al. 2012. The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness. J. Acquir. Immune Defic. Syndr. 59:47-54.
    • (2012) J. Acquir. Immune Defic. Syndr. , vol.59 , pp. 47-54
    • Kulkarni, R.1
  • 32
    • 60749124402 scopus 로고    scopus 로고
    • Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India
    • Kulkarni SS, et al. 2009. Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. Virology 385:505-520.
    • (2009) Virology , vol.385 , pp. 505-520
    • Kulkarni, S.S.1
  • 33
    • 0028789990 scopus 로고
    • Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase
    • Le Grice SF, Cameron CE, Benkovic SJ. 1995. Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase. Methods Enzymol. 262:130-144.
    • (1995) Methods Enzymol , vol.262 , pp. 130-144
    • Le Grice, S.F.1    Cameron, C.E.2    Benkovic, S.J.3
  • 34
    • 79551550417 scopus 로고    scopus 로고
    • Clinical trial report, TMC278 (rilpivirine) versus efavirenz as initial therapy in treatment-naive HIV-1-infected patients
    • Macarthur RD. 2011. Clinical trial report: TMC278 (rilpivirine) versus efavirenz as initial therapy in treatment-naive, HIV-1-infected patients. Curr. Infect. Dis. Rep. 13:1-3.
    • (2011) Curr. Infect. Dis. Rep. , vol.13 , pp. 1-3
    • Macarthur, R.D.1
  • 35
    • 80054865518 scopus 로고    scopus 로고
    • HIV- 1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors
    • Menendez-Arias L, Betancor G, Matamoros T. 2011. HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors. Antiviral Res. 92:139-149.
    • (2011) Antiviral Res , vol.92 , pp. 139-149
    • Menendez-Arias, L.1    Betancor, G.2    Matamoros, T.3
  • 36
    • 0027976787 scopus 로고
    • Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools
    • Meyerhans A, et al. 1994. Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools. J. Virol. 68:535-540.
    • (1994) J. Virol. , vol.68 , pp. 535-540
    • Meyerhans, A.1
  • 37
    • 3543066286 scopus 로고    scopus 로고
    • Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency
    • Nikolenko GN, Svarovskaia ES, Delviks KA, Pathak VK. 2004. Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency. J. Virol. 78:8761-8770.
    • (2004) J. Virol. , vol.78 , pp. 8761-8770
    • Nikolenko, G.N.1    Svarovskaia, E.S.2    Delviks, K.A.3    Pathak, V.K.4
  • 38
    • 60349093648 scopus 로고    scopus 로고
    • Isolation of drug-resistant mutant HIV variants using tissue culture drug selection
    • Oliveira M, Brenner BG, Wainberg MA. 2009. Isolation of drug-resistant mutant HIV variants using tissue culture drug selection. Methods Mol. Biol. 485:427-433.
    • (2009) Methods Mol. Biol. , vol.485 , pp. 427-433
    • Oliveira, M.1    Brenner, B.G.2    Wainberg, M.A.3
  • 39
    • 34248393491 scopus 로고    scopus 로고
    • Insertion of a small peptide of six amino acids into the beta7-beta8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
    • doi, 10. 1186/1471-2091-
    • Pandey PK, et al. 2002. Insertion of a small peptide of six amino acids into the beta7-beta8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities. BMC Biochem. 3:18. doi:10.1186/1471-2091-3-18.
    • (2002) BMC Biochem , vol.3 , pp. 18
    • Pandey, P.K.1
  • 40
    • 0035859690 scopus 로고    scopus 로고
    • The beta7-beta8 loop of the p51 subunit in the heterodimeric (p66/p51) human immunodeficiency virus type 1 reverse transcriptase is essential for the catalytic function of the p66 subunit
    • Pandey PK, Kaushik N, Talele TT, Yadav PN, Pandey VN. 2001. The beta7-beta8 loop of the p51 subunit in the heterodimeric (p66/p51) human immunodeficiency virus type 1 reverse transcriptase is essential for the catalytic function of the p66 subunit. Biochemistry 40:9505-9512.
    • (2001) Biochemistry , vol.40 , pp. 9505-9512
    • Pandey, P.K.1    Kaushik, N.2    Talele, T.T.3    Yadav, P.N.4    Pandey, V.N.5
  • 41
    • 0141705300 scopus 로고    scopus 로고
    • Drug resistance profiles of recombinant reverse transcriptases from human immunodeficiency virus type 1 subtypes A/E, B, and C
    • Quan Y, et al. 2003. Drug resistance profiles of recombinant reverse transcriptases from human immunodeficiency virus type 1 subtypes A/E, B, and C. AIDS Res. Hum. Retroviruses 19:743-753.
    • (2003) AIDS Res. Hum. Retroviruses , vol.19 , pp. 743-753
    • Quan, Y.1
  • 42
    • 77749316840 scopus 로고    scopus 로고
    • Anti-HIV-1 and anti-inflammatory lupanes from the leaves, twigs, and resin of Garcinia hanburyi
    • Reutrakul V, et al. 2010. Anti-HIV-1 and anti-inflammatory lupanes from the leaves, twigs, and resin of Garcinia hanburyi. Planta Med. 76: 368-371.
    • (2010) Planta Med , vol.76 , pp. 368-371
    • Reutrakul, V.1
  • 43
    • 34249022980 scopus 로고    scopus 로고
    • GALAHAD 1. Pharmacophore identification by hypermolecular alignment of ligands in 3D
    • Richmond NJ, et al. 2006. GALAHAD. 1. Pharmacophore identification by hypermolecular alignment of ligands in 3D. J. Comput. Aided Mol. Des. 20:567-587.
    • (2006) J. Comput. Aided Mol. Des. , vol.20 , pp. 567-587
    • Richmond, N.J.1
  • 44
    • 78649659732 scopus 로고    scopus 로고
    • The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine
    • Schuckmann MM, et al. 2010. The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. J. Biol. Chem. 285:38700-38709.
    • (2010) J. Biol. Chem. , vol.285 , pp. 38700-38709
    • Schuckmann, M.M.1
  • 45
    • 0028271687 scopus 로고
    • Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1
    • Smerdon SJ, et al. 1994. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. U. S. A. 91:3911-3915.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 3911-3915
    • Smerdon, S.J.1
  • 46
    • 78649305180 scopus 로고    scopus 로고
    • Characterization of genotypic and phenotypic changes in HIV-1-infected patients with virologic failure on an etravirinecontaining regimen in the DUET-1 and DUET-2 clinical studies
    • Tambuyzer L, et al. 2010. Characterization of genotypic and phenotypic changes in HIV-1-infected patients with virologic failure on an etravirinecontaining regimen in the DUET-1 and DUET-2 clinical studies. AIDS Res. Hum. Retroviruses 26:1197-1205.
    • (2010) AIDS Res. Hum. Retroviruses , vol.26 , pp. 1197-1205
    • Tambuyzer, L.1
  • 47
    • 79952302434 scopus 로고    scopus 로고
    • Does the M184V resistance mutation in reverse transcriptase reduce HIV transmission?
    • Turner D. 2011. Does the M184V resistance mutation in reverse transcriptase reduce HIV transmission? HIV Med. 12:193-194.
    • (2011) HIV Med , vol.12 , pp. 193-194
    • Turner, D.1
  • 48
    • 0344825778 scopus 로고    scopus 로고
    • Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1
    • Turner D, Brenner B, Wainberg MA. 2003. Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1. Clin. Diagn. Lab. Immunol. 10:979-981.
    • (2003) Clin. Diagn. Lab. Immunol. , vol.10 , pp. 979-981
    • Turner, D.1    Brenner, B.2    Wainberg, M.A.3
  • 49
    • 74949086940 scopus 로고    scopus 로고
    • A single deletion at position 134 135 or 136 in the beta 7-beta 8 loop of the p51 subunit of HIV-1 RT disrupts the formation of heterodimeric enzyme
    • Upadhyay A, Pandey N, Mishra CA, Talele TT, Pandey VN. 2010. A single deletion at position 134, 135, or 136 in the beta 7-beta 8 loop of the p51 subunit of HIV-1 RT disrupts the formation of heterodimeric enzyme. J. Cell. Biochem. 109:598-605.
    • (2010) J. Cell. Biochem. , vol.109 , pp. 598-605
    • Upadhyay, A.1    Pandey, N.2    Mishra, C.A.3    Talele, T.T.4    Pandey, V.N.5
  • 50
    • 84755161158 scopus 로고    scopus 로고
    • Mechanistic interplay among the M184I HIV-1 reverse transcriptase mutant, the central polypurine tract, cellular dNTP concentrations and drug sensitivity
    • Van Cor-Hosmer SK, Daddacha W, Kim B. 2010. Mechanistic interplay among the M184I HIV-1 reverse transcriptase mutant, the central polypurine tract, cellular dNTP concentrations and drug sensitivity. Virology 406:253-260.
    • (2010) Virology , vol.406 , pp. 253-260
    • Van Cor-Hosmer, S.K.1    Daddacha, W.2    Kim, B.3
  • 51
    • 2942560805 scopus 로고    scopus 로고
    • The impact of the M184V substitution on drug resistance and viral fitness
    • Wainberg MA. 2004. The impact of the M184V substitution on drug resistance and viral fitness. Expert Rev. Anti Infect. Ther. 2:147-151.
    • (2004) Expert Rev. Anti Infect. Ther. , vol.2 , pp. 147-151
    • Wainberg, M.A.1
  • 53
    • 70350331091 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine
    • Xu H, et al. 2009. Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine. Antimicrob. Agents Chemother. 53:4667-4672.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4667-4672
    • Xu, H.1
  • 54
    • 80055119045 scopus 로고    scopus 로고
    • Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations
    • Xu HT, et al. 2011. Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. J. Virol. 85:11300-11308.
    • (2011) J. Virol. , vol.85 , pp. 11300-11308
    • Xu, H.T.1
  • 55
    • 77957873651 scopus 로고    scopus 로고
    • Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function
    • Xu HT, Oliveira M, Quan Y, Bar-Magen T, Wainberg MA. 2010. Differential impact of the HIV-1 non-nucleoside reverse transcriptase inhibitor mutations K103N and M230L on viral replication and enzyme function. J. Antimicrob. Chemother. 65:2291-2299.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 2291-2299
    • Xu, H.T.1    Oliveira, M.2    Quan, Y.3    Bar-Magen, T.4    Wainberg, M.A.5
  • 56
    • 77957377561 scopus 로고    scopus 로고
    • Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C. Retrovirology 7, 80. doi
    • Xu HT, et al. 2010. Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C. Retrovirology 7:80. doi:10.1186/1742-4690-7-80.
    • (2010) 10. 1186/1742-4690- , pp. 7-80
    • Xu, H.T.1
  • 57
    • 38049028352 scopus 로고    scopus 로고
    • N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance
    • doi, 10.1371/journal.pmed.0040335
    • Yap SH, et al. 2007. N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. PLoS Med. 4:e335. doi:10.1371/journal.pmed.0040335.
    • (2007) PLoS Med , vol.4
    • Yap, S.H.1


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