A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: Implications for antiviral drug development

Journal of Biomolecular Screening

Volumn 16, Issue 8, 2011, Pages 852-861

  Geiss, Brian J ^a   Stahla Beek, Hillary J ^b   Hannah, Amanda M ^b   Gari, Hamid H ^a   Henderson, Brittney R ^a   Saeedi, Bejan J ^a   Keenan, Susan M ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

Anti infective drugs; Drug development; Flavivirus; Fluorescence polarization (FP); High throughput screening; NS5 N terminal capping enzyme (CE)

Indexed keywords

DOCKING PROTEIN; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATE ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BINDING SITE; ENZYME BINDING; FALSE POSITIVE RESULT; FLAVIVIRUS; FLUORESCENCE; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; VALIDATION STUDY; VIRUS IDENTIFICATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FLAVIVIRUS; FLAVIVIRUS INFECTIONS; FLUORESCENCE; GUANOSINE TRIPHOSPHATE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA CAPS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

FLAVIVIRUS;

EID: 80054773940     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111412183     Document Type: Article

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