Identification and characterization of inhibitors of West Nile virus

Antiviral Research

Volumn 83, Issue 1, 2009, Pages 71-79

  Puig Basagoiti, Francesc ^a   Qing, Min ^a,b   Dong, Hongping ^a   Zhang, Bo ^a   Zou, Gang ^a,b   Yuan, Zhiming ^b   Shi, Pei Yong ^a,c  

^a WADSWORTH CENTER   (United States)

^b WUHAN INSTITUTE OF VIROLOGY   (China)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Antiviral drug discovery; Flavivirus replication; High throughput screening; RNA cap methyltransferase; RNA dependent RNA polymerase; West Nile virus

Indexed keywords

ANTIVIRUS AGENT; METHYLTRANSFERASE; RNA DIRECTED RNA POLYMERASE; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS INHIBITION; VIRUS REPLICATION; WEST NILE FLAVIVIRUS;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; METHYLTRANSFERASES; PROTEIN BIOSYNTHESIS; RNA REPLICASE; RNA, VIRAL; TRANSCRIPTION, GENETIC; VERO CELLS; VIRAL PROTEINS; WEST NILE VIRUS;

FLAVIVIRUS; WEST NILE VIRUS;

EID: 67349221783     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.03.005     Document Type: Article

References (49)

1. Anderson J.F., and Rahal J.J. Efficacy of interferon alpha-2b and ribavirin against West Nile virus in vitro. Emerg. Infect. Dis. 8 1 (2002) 107-108
2. Bai F., Wang T., Pal U., Bao F., Gould L.H., and Fikrig E. Use of RNA interference to prevent lethal murine west nile virus infection. J. Infect. Dis. 191 7 (2005) 1148-1154
3. Ben-Nathan D., Lustig S., Tam G., Robinzon S., Segal S., and Rager-Zisman B. Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treating West Nile virus infection in mice. J. Infect. Dis. 188 1 (2003) 5-12
4. Best S.M., Morris K.L., Shannon J.G., Robertson S.J., Mitzel D.N., Park G.S., Boer E., Wolfinbarger J.B., and Bloom M.E. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. J. Virol. 79 20 (2005) 12828-12839
5. Chambers T.J., Hahn C.S., Galler R., and Rice C.M. Flavivirus genome organization, expression, and replication. Annu. Rev. Microbiol. 44 (1990) 649-688
6. Courageot M.P., Frenkiel M.P., Dos Santos C.D., Deubel V., and Despres P. Alpha-glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum. J. Virol. 74 1 (2000) 564-572
7. Deas T.S., Binduga-Gajewska I., Tilgner M., Ren P., Stein D.A., Moulton H.M., Iversen P.L., Kauffman E.B., Kramer L.D., and Shi P.-Y. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J. Virol. 79 8 (2005) 4599-4609
8. Deas T.S., Bennett C.J., Jones S.A., Tilgner M., Ren P., Behr M.J., Stein D.A., Iversen P.L., Kramer L.D., Bernard K.A., and Shi P.-Y. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob. Agents Chemother. 51 (2007) 2470-2482
9. Dong H., Ray D., Ren S., Zhang B., Puig-Basagoiti F., Takagi Y., Ho C.K., Li H., and Shi P.Y. Distinct RNA elements confer specificity to flavivirus RNA cap methylation events. J. Virol. 81 9 (2007) 4412-4421
10. Egloff M.P., Benarroch D., Selisko B., Romette J.L., and Canard B. An RNA cap (nucleoside-2′-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. EMBO J. 21 11 (2002) 2757-2768
11. Engle M., and Diamond M. Antibody prophylaxis and therapy against West Nile virus infection in wild-type and immunodeficient mice. J. Virol. 77 24 (2003) 12941-12949
12. Gu B., Ouzunov S., Wang L., Mason P., Bourne N., Cuconati A., and Block T.M. Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen. Antiviral Res. 70 2 (2006) 39-50
13. Gubler D., Kuno G., and Markoff L. Flaviviruses. In: Knipe D.M., and Howley P.M. (Eds). Fields Virology. 5th ed. vol.1 (2007), Lippincott William & Wilkins, Philadelphia, PA 1153-1253
14. Guo J., Hayashi J., and Seeger C. West nile virus inhibits the signal transduction pathway of alpha interferon. J. Virol. 79 3 (2005) 1343-1350
15. Holden K., Stein D., Pierson T., Ahmed A., Clyde K., Iversen P., and Harris E. Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3′ stem-loop structure. Virology 344 2 (2006) 439-452
16. Julander J.G., Winger Q.A., Olsen A.L., Day C.W., Sidwell R.W., and Morrey J.D. Treatment of West Nile virus-infected mice with reactive immunoglobulin reduces fetal titers and increases dam survival. Antiviral Res. 65 2 (2005) 79-85
17. Kimura-Kuroda J., and Yasui K. Protection of mice against Japanese encephalitis virus by passive administration with monoclonal antibodies. J. Immunol. 141 10 (1988) 3606-3610
18. Kinney R., Huang C., Rose B., Kroeker A., Dreher T., Iversen P., and Stein D. Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. J. Virol. 79 8 (2005) 5116-5128
19. Koonin E.V. Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus. J. Gen. Virol. 74 Pt 4 (1993) 733-740
20. Kramer L., Li J., and Shi P.-Y. West Nile virus. Lancet Neurol. 6 (2007) 171-182
21. Kumar P., Lee S.K., Shankar P., and Manjunath N. A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. PLoS Med. 3 4 (2006) e96
22. Kummerer B.M., and Rice C.M. Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles. J. Virol. 76 10 (2002) 4773-4784
23. Liu W.J., Chen H.B., and Khromykh A.A. Molecular and functional analyses of Kunjin virus infectious cDNA clones demonstrate the essential roles for NS2A in virus assembly and for a nonconservative residue in NS3 in RNA replication. J. Virol. 77 14 (2003) 7804-7813
24. Lin R.-J., Liao C.-L., Lin E., and Lin Y.-L. Blocking the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection. J. Virol. 78 17 (2004) 9285-9294
25. Liu W., Wang X., Mokhonov V., Shi P.-Y., Randall R., and Khromykh A. Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. J. Virol. 79 3 (2005) 1934-1942
26. Lo L., Tilgner M., Bernard K., and Shi P.-Y. Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3′ untranslated region of West Nile virus using a reporting replicon that differentiates between viral translation and RNA replication. J. Virol. 77 18 (2003) 10004-10014
27. Lo M.K., Tilgner M., Bernard K.A., and Shi P.Y. Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3′ untranslated region of West Nile virus by use of a reporting replicon that differentiates between viral translation and RNA replication. J. Virol. 77 18 (2003) 10004-10014
28. Lo L., Tilgner M., and Shi P.-Y. A potential high-throughput assay for screening inhibitors of West Nile virus replication. J. Virol. 77 23 (2003) 12901-12906
29. Mathews J.H., and Roehrig J.T. Elucidation of the topography and determination of the protective epitopes on the E glycoprotein of Saint Louis encephalitis virus by passive transfer with monoclonal antibodies. J. Immunol. 132 3 (1984) 1533-1537
30. Michaelis M., Kleinschmidt M.H.W.D., and Cinatl J.J. Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells. J. Antimicrob. Chemother. 60 5 (2007) 981-986
31. Munoz-Jordan J.L., Laurent-Rolle M., Ashour J., Martinez-Sobrido L., Ashok M., Lipkin W.I., and Garcia-Sastre A. Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J. Virol. 79 13 (2005) 8004-8013
32. Munoz-Jordan J.L., Sanchez-Burgos G.G., Laurent-Rolle M., and Garcia-Sastre A. Inhibition of interferon signaling by dengue virus. Proc. Natl. Acad. Sci. U.S.A. 100 24 (2003) 14333-14338
33. Murakami M., Ota T., Nukuzuma S., and Takegami T. Inhibitory effect of RNAi on Japanese encephalitis virus replication in vitro and in vivo. Microbiol. Immunol. 49 12 (2005) 1047-1056
34. Noueiry A., Olivo P., Slomczynska U., Zhou Y., Buscher B., Geiss B., Engle M., Roth R., Chung K., Samuel M., and Diamond M. Identification of novel small-molecule inhibitors of West Nile virus infection. J. Virol. 81 21 (2007) 11992-12004
35. Puig-Basagoiti F., Deas T.S., Ren P., Tilgner M., Ferguson D.M., and Shi P.-Y. High-throughput assays using luciferase-expressing replicon, virus-like particle, and full-length virus for West Nile virus drug discovery. Antimicrob. Agent. Chemother. 49 12 (2005) 4980-4988
36. Puig-Basagoiti F., Tilgner M., Forshey B., Philpott S., Espina N., Wentworth, Goebel S., Masters P.S., Falgout B., Ren P., Ferguson, and Shi P.Y. Triaryl pyrazoline compound inhibits flavivirus RNA replication. Antimicrob. Agents Chemother. 50 4 (2006) 1320-1329
37. Puig-Basagoiti F., Tilgner M., Bennett C., Zhou Y., Munoz-Jordan J., Garcia-Sastre A., Bernard K., and Shi P.-Y. A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis. Virology 361 (2007) 229-241
38. Ray D., Shah A., Tilgner M., Guo Y., Zhao Y., Dong H., Deas T., Zhou Y., Li H., and Shi P.-Y. West nile virus 5′-cap structure is formed by sequential guanine N-7 and ribose 2′-O methylations by nonstructural protein 5. J. Virol. 80 17 (2006) 8362-8370
39. Schlesinger J.J., Brandriss M.W., and Walsh E.E. Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48. J. Immunol. 135 4 (1985) 2805-2809
40. Shi, P.-Y. (2008). Novel therapeutics against West Nile virus. In: Diamond, M.S. (Ed.), West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response. Springer Publisher, pp. 453-474.
41. Shi P.Y., Tilgner M., Lo M.K., Kent K.A., and Bernard K.A. Infectious cDNA clone of the epidemic West Nile virus from New York City. J. Virol. 76 12 (2002) 5847-5856
42. Tan B.H., Fu J., Sugrue R.J., Yap E.H., Chan Y.C., and Tan Y.H. Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity. Virology 216 2 (1996) 317-325
43. Tilgner M., Deas T.S., and Shi P.-Y. The flavivirus-conserved penta-nucleotide in the 3′ stem-loop of the West Nile virus genome requires a specific sequence and structure for RNA synthesis, but not for viral translation. Virology 331 (2005) 375-386
44. Wengler G., and Wengler G. The carboxy-terminal part of the NS 3 protein of the West Nile flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase. Virology 184 2 (1991) 707-715
45. Whitby K., Pierson T., Geiss B., Lane K., Engle M., Zhou Y., Doms R., and Diamond M. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J. Virol. 79 14 (2005) 8698-8706
46. Wu S.-F., Lee C.-J., Liao C.-L., Dwek R., Zitzmann N., and Lin Y.-L. Antiviral effects of an iminosugar derivative on flavivirus infections. J. Virol. 76 8 (2002) 3596-3604
47. Zhang B., Dong H., Zhou Y., and Shi P.Y. Genetic interactions among the West Nile virus methyltransferase, the RNA-dependent RNA polymerase, and the 5′ stem-loop of genomic RNA. J. Virol. 82 14 (2008) 7047-7058
48. Zhou Y., Ray D., Zhao Y., Dong H., Ren S., Li Z., Guo Y., Bernard K., Shi P.-Y., and Li H. Structure and function of flavivirus NS5 methyltransferase. J. Virol. 81 8 (2007) 3891-3903
49. Zou G., Puig-Basagoiti F., Zhang B., Qing M., Chen L., Pankiewicz K., Felczak K., Yuan Z., and Shi P.Y. A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor. Virology 384 1 (2009) 242-252