An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents

Toxicology and Applied Pharmacology

Volumn 263, Issue 2, 2012, Pages 138-147

  Mercado Feliciano, Minerva ^a   Cora, Michelle C ^a   Witt, Kristine L ^a   Granville, Courtney A ^b   Hejtmancik, Milton R ^b   Fomby, Laurene ^b   Knostman, Katherine A ^b   Ryan, Michael J ^b   Newbold, Retha ^a   Smith, Cynthia ^a   Foster, Paul M ^a   Vallant, Molly K ^a   Stout, Matthew D ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Actaea racemosa; Black cohosh; Genetic toxicity; Micronucleus; Non regenerative macrocytic anemia

Indexed keywords

CIMICIFUGA RACEMOSA EXTRACT; HEMOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CIMICIFUGA RACEMOSA; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE COUNT; ESTROGEN ACTIVITY; ESTRUS; ESTRUS CYCLE; FEEDING; FEMALE; GYNECOLOGICAL EXAMINATION; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; LEUKOCYTE COUNT; LIVER CELL; LIVER TOXICITY; MACROCYTIC ANEMIA; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MICRONUCLEUS TEST; MOUSE; NONHUMAN; ORGAN WEIGHT; PUBERTY; RAT; RETICULOCYTE; SURVIVAL; THROMBOCYTE COUNT; THYMUS DISEASE; TOXICITY TESTING; TREATMENT DURATION;

ANEMIA, MACROCYTIC; ANIMALS; CIMICIFUGA; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; ESTROGENS; ETHANOL; FEMALE; HEMATOLOGIC DISEASES; LIVER; MICE; PLANT EXTRACTS; RATS; RATS, WISTAR; SEVERITY OF ILLNESS INDEX; SEXUAL MATURATION; SPECIES SPECIFICITY; THYMUS GLAND; TOXICITY TESTS;

CIMICIFUGA DAHURICA; CIMICIFUGA RACEMOSA; MUS; RATTUS; RODENTIA;

EID: 84865066656     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.05.022     Document Type: Article

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