Efficacy of Cimicifuga racemosa on climacteric complaints: A randomized study versus low-dose transdermal estradiol

Gynecological Endocrinology

Volumn 20, Issue 1, 2005, Pages 30-35

  Nappi, Rossella E ^a   Malavasi, Barbara ^b   Brundu, Benedetta ^a   Facchinetti, Fabio ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cimicifuga racemosa; Herbal remedies; Hot flushes; Low dose hormone replacement therapy; Transdermal estradiol

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CIMICIFUGA RACEMOSA EXTRACT; DYDROGESTERONE; ESTRADIOL; FOLLITROPIN; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; TRIACYLGLYCEROL;

ADULT; ANXIETY DISORDER; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; ENDOMETRIUM; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HERBAL MEDICINE; HOT FLUSH; HUMAN; HYDROCORTISONE BLOOD LEVEL; ITALY; LIVER FUNCTION TEST; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MENOPAUSAL SYNDROME; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; UROGENITAL TRACT DISEASE; VASOMOTOR DISORDER;

ADMINISTRATION, CUTANEOUS; CIMICIFUGA; ESTRADIOL; FEMALE; GONADAL STEROID HORMONES; HOT FLASHES; HUMANS; MENOPAUSE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 15944403978     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590400020922     Document Type: Article

References (39)

1. Grimes DA, Lobo RA. Perspectives on the Women's Health Initiative trial of hormone replacement therapy. Obstet Gynecol 2002;100:1344-1353.
2. Schneider HP, Gallagher JC. Moderation of the daily dose of HRT: benefits for patients. Maturitas 1999;33:S25-S29.
3. Ettinger B. Personal perspective on low-dosage estrogen therapy for postmenopausal women. Menopause 1999;6: 273-276.
4. Gambacciani M, Genazzani AR. Hormone replacement therapy: the benefits in tailoring the regimen and dose. Maturitas 2001;40:195-201.
5. Archer DF, Dorin M, Lewis V, Schneider DL, Pickar JH. Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on endometrial bleeding. Fertil Steril 2001;75:1080-1087.
6. Brynhildsen J, Hammar M. Low dose transdermal estradiol/norethisterone acetate treatment over 2 years does not cause endometrial proliferation in postmenopausal women. Menopause 2002;9:137-144.
7. Evans SF, Davie MW. Low and conventional dose transdermal oestradiol are equally effective at preventing bone loss in spine and femur at all post-menopausal ages. Clin Endocrinol (Oxf) 1996;44:79-84.
8. Gambacciani M, Ciaponi M, Cappagli B, Genazzani AR. Effects of low-dose continuous combined conjugated estrogens and medroxyprogesterone acetate on menopausal symptoms, body weight, bone density, and metabolism in postmenopausal women. Am J Obstet Gynecol 2001;185: 1180-1185.
9. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002;137: 805-813.
10. Gingrich PM, Fogel CI. Herbal therapy use by perimenopausal women. J Obstet Gynecol Neonatal Nurs 2003;32: 181-189.
11. Newton KM, Buist DS, Keenan NL, Anderson LA, LaCroix AZ. Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet Gynecol 2002;100:18-25.
12. Gass ML, Taylor MB. Alternatives for women through menopause. Am J Obstet Gynecol 2001;185:S47-S56.
13. McKenna DJ, Jones K, Humphrey S, Hughes K. Black cohosh: efficacy, safety, and use in clinical and preclinical applications. Altern Ther Health Med 2001;7:93-100.
14. Lieberman S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause. J Womens Health 1998;7:525-529.
15. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynaecologic disorders. Adv Ther 1998;15:45-53.
16. Borrelli F, Ernst E. Cimicifuga racemosa: a systematic review of its clinical efficacy. Eur J Clin Phannacol 2002;58:235-241.
17. Huntley A, Ernst E. A systematic review of the safety of black cohosh. Menopause 2003;10:58-64.
18. Liske E, Hanggi W, Henneicke-von Zepelin HH, Boblitz N, Wustenberg P, Rahlfs VW. Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med 2002; 11:163-174.
19. Israel D, Youngkin EQ. Herbal therapies for perimenopausal and menopausal complaints. Pharmacotherapy 1997;17:970-984.
20. Wuttke W, Seidlova-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003;44:867-877.
21. Wuttke W, Jarry H, Becker T, Schultens A, Christoffel V, Gorkow C, Seidlova-Wuttke D. Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy? Maturitas 2003;44:S9-S20.
22. Seidlova-Wuttke D, Jarry H, Becker T, Christoffel V, Wuttke W. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Maturitas 2003;44:S39-S50.
23. Jarry H, Metten M, Spengler B, Christoffel V, Wuttke W. In vitro effects of the Cimicifuga racemosa extract BNO 1055. Maturitas 2003;44:S31-S38.
24. Winterhoff H, Spengler B, Christoffel V, Butterweck V, Lohning A. Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity. Maturitas 2003;44:551-558.
25. Greene JG. A factor analytic study of climacteric symptoms. J Psychosom Res 1976;20:425-430.
26. Fava GA, Kellner R, Perini GI, Fava M, Michelacci L, Munan F, Evangelisti LP, Grandi S, Bernardi M, Mastrogiacomo I. Italian validation of the Symptom Rating Test (SRT) and Symptom Questionnaire (SQ). Can J Psychiatry 1983;28:117-123.
27. Utian WH, Burry KA, Archer DF, Gallagher JC, Boyett RL, Guy MP, Tachon GJ, Chadha-Boreham HK, Bouvet AA. Efficacy and safety of low, standard, and high dosages of an estradiol transdermal system (Esclim) compared with placebo on vasomotor symptoms in highly symptomatic menopausal patients. The Esclim Study Group. Am J Obstet Gynecol 1999;181:71-79.
28. Duker EM, Kopanski L, Jarry H, Wuttke W. Effects of extracts from Cimicifuga racemosa on gonadotropin release in menopausal women and ovariectomized rats. Planta Med 1991;57:420-424.
29. Einer-Jensen N, Zhao J, Andersen KP, Kristoffersen K. Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats. Maturitas 1996;25:149-153.
30. Freudenstein J, Dasenbrock C, Nisslein T. Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res 2002;62:3448-3452.
31. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-150.
32. Wuttke W, Jarry H, Westphalen S, Christoffel V, Seidlova-Wuttke D. Phytoestrogens for hormone replacement therapy? J Steroid Biochem Mol Biol 2002;83:133-147.
33. Zierau O, Bodinet C, Kolba S, Wulf M, Vollmer G. Antiestrogenic activities of Cimicifuga racemosa extracts. J Steroid Biochem Mol Biol 2002;80:125-130.
34. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252-4263.
35. Hernandez Munoz G, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 2003;44:S59-S65.
36. Jacobson JS, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, Lo KM, Moore A, Rosenman PJ, Kaufman EL, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001;19:2739-2745.
37. Fitzpatrick LA. Soy isoflavones: hope or hype? Maturitas 2003;44:S21-S29.
38. Godsland IF. Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000. Fertil Steril 2001;75:898-915.
39. Tesch BJ. Herbs commonly used by women: an evidence-based review. Am J Obstet Gynecol 2003;188:S44-S55.