GABAA receptor α subunits differentially contribute to diazepam tolerance after Chronic treatment

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Vinkers, Christiaan H ^a,b   van Oorschot, Ruud ^a   Nielsen, Elsebet Ø ^c   Cook, James M ^d   Hansen, Henrik H ^c,e   Groenink, Lucianne ^a   Olivier, Berend ^a,f   Mirza, Naheed R ^c,g  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c NEUROSEARCH A S   (Denmark)

^d UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^e Gubra ApS   (Denmark)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Aniona ApS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; BRETAZENIL; DIAZEPAM; MESSENGER RNA; ZOLPIDEM;

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1 GENE; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2 GENE; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5 GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL BODY TEMPERATURE; BINDING KINETICS; BRAIN REGION; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG TOLERANCE; GENE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN VIVO STUDY; LONG TERM CARE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; SEDATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINONES; BODY TEMPERATURE; BRAIN; DIAZEPAM; DNA PRIMERS; DRUG TOLERANCE; FLUMAZENIL; HYPNOTICS AND SEDATIVES; IN SITU HYBRIDIZATION; MALE; MICE; MICE, MUTANT STRAINS; PYRIDAZINES; PYRIDINES; RECEPTORS, GABA-A; TRIAZOLES;

EID: 84865049988     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043054     Document Type: Article

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