LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages

Journal of Biological Chemistry

Volumn 287, Issue 33, 2012, Pages 27691-27702

  Glowacka, Wioletta K ^a   Alberts, Philipp ^a   Ouchida, Rika ^b   Wang, Ji Yang ^b   Rotin, Daniela ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL RECEPTOR; B CELLS; CELLULAR COMPARTMENTS; CYTOKINE SECRETIONS; CYTOKINES; IMMUNE CELLS; INFLAMMATORY SIGNALING; MAPK SIGNALING; NEGATIVE REGULATORS; PATTERN RECOGNITION RECEPTORS; PROINFLAMMATORY; PROINFLAMMATORY CYTOKINES; RECEPTOR-INTERACTING PROTEINS; SIGNALING PATHWAYS; TOLL-LIKE RECEPTORS; TRANSMEMBRANES; UBIQUITIN LIGASES; UBIQUITINATION;

CELL MEMBRANES; ENZYMES; MAMMALS; PATTERN RECOGNITION; PHYSIOLOGY; PROTEINS; SIGNALING;

MACROPHAGES;

CARRIER PROTEINS AND BINDING PROTEINS; CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LYSOSOMAL ASSOCIATED PROTEIN TRANSMEMBRANE 5; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PATTERN RECOGNITION RECEPTOR; RECEPTOR INTERACTING PROTEIN 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; UBIQUITIN; UBIQUITIN EDITING ENZYME A20; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOSOME; INFLAMMATION; LYSOSOME; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; ENDOSOMES; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; IMMEDIATE-EARLY PROTEINS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NF-KAPPA B; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84865041345     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355917     Document Type: Article

References (36)

1. Adra, C. N., Zhu, S., Ko, J. L., Guillemot, J. C., Cuervo, A. M., Kobayashi, H., Horiuchi, T., Lelias, J. M., Rowley, J. D., and Lim, B. (1996) LAPTM5. A novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Genomics 35, 328-337
2. Scott, L. M., Mueller, L., and Collins, S. J. (1996) E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor α. Blood 88, 2517-2530
3. Pak, Y., Glowacka, W. K., Bruce, M. C., Pham, N., and Rotin, D. (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J. Cell Biol. 175, 631-645
4. Ouchida, R., Kurosaki, T., and Wang, J. Y. (2010) A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation. J. Immunol. 185, 294-301
5. Ouchida, R., Yamasaki, S., Hikida, M., Masuda, K., Kawamura, K., Wada, A., Mochizuki, S., Tagawa, M., Sakamoto, A., Hatano, M., Tokuhisa, T., Koseki, H., Saito, T., Kurosaki, T., and Wang, J. Y. (2008) A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3ζ-chain degradation. Immunity 29, 33-43
6. Mosser, D. M., and Edwards, J. P. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969
7. Hayden, M. S., and Ghosh, S. (2011) NF-κB in immunobiology. Cell Res. 21, 223-244
8. Rothwarf, D. M., and Karin, M. (1999) The NF-κB activation pathway. A paradigm in information transfer from membrane to nucleus. Sci. STKE 1999, RE1
9. Häcker, H., and Karin, M. (2006) Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006, re13
10. Viatour, P., Merville, M. P., Bours, V., and Chariot, A. (2005) Phosphorylation of NF-κB and IκB proteins. Implications in cancer and inflammation. Trends Biochem. Sci. 30, 43-52
11. Oeckinghaus, A., Hayden, M. S., and Ghosh, S. (2011) Crosstalk in NF-κB signaling pathways. Nat. Immunol. 12, 695-708
12. Skaug, B., Jiang, X., and Chen, Z. J. (2009) The role of ubiquitin in NF-κB regulatory pathways. Annu. Rev. Biochem. 78, 769-796
13. Wertz, I. E., O'Rourke, K. M., Zhou, H., Eby, M., Aravind, L., Seshagiri, S., Wu, P., Wiesmann, C., Baker, R., Boone, D. L., Ma, A., Koonin, E. V., and Dixit, V. M. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 430, 694-699
14. Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R. C., Wheeler, M. T., Tsui, C., Hurley, P., Chien, M., Chai, S., Hitotsumatsu, O., McNally, E., Pickart, C., and Ma, A. (2004) The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol. 5, 1052-1060
15. Hitotsumatsu, O., Ahmad, R. C., Tavares, R., Wang, M., Philpott, D., Turer, E. E., Lee, B. L., Shiffin, N., Advincula, R., Malynn, B. A., Werts, C., and Ma, A. (2008) The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28, 381-390
16. Kumar, A., Takada, Y., Boriek, A. M., and Aggarwal, B. B. (2004) Nuclear factor-κB. Its role in health and disease. J. Mol. Med. 82, 434-448
17. Paddison, P. J., Cleary, M., Silva, J. M., Chang, K., Sheth, N., Sachidanandam, R., and Hannon, G. J. (2004) Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat. Methods 1, 163-167
18. Barton, G. M., and Kagan, J. C. (2009) A cell biological view of Toll-like receptor function. Regulation through compartmentalization. Nat. Rev. Immunol. 9, 535-542
19. Sun, S. C., Ganchi, P. A., Ballard, D. W., and Greene, W. C. (1993) NF-κB controls expression of inhibitor IκBα. Evidence for an inducible autoregulatory pathway. Science 259, 1912-1915
20. Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne, A., Thomas, G., Philpott, D. J., and Sansonetti, P. J. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869-8872
21. Colland, F., Jacq, X., Trouplin, V., Mougin, C., Groizeleau, C., Hamburger, A., Meil, A., Wojcik, J., Legrain, P., and Gauthier, J. M. (2004) Functional proteomics mapping of a human signaling pathway. Genome Res. 14, 1324-1332
22. Li, L., Hailey, D. W., Soetandyo, N., Li, W., Lippincott-Schwartz, J., Shu, H. B., and Ye, Y. (2008) Localization of A20 to a lysosome-associated compartment and its role in NFκB signaling. Biochim. Biophys. Acta 1783, 1140-1149
23. Zhang, S. Q., Kovalenko, A., Cantarella, G., and Wallach, D. (2000) Recruitment of the IKK signalosome to the p55 TNF receptor. RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation. Immunity 12, 301-311
24. Legler, D. F., Micheau, O., Doucey, M. A., Tschopp, J., and Bron, C. (2003) Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity 18, 655-664
25. Pobezinskaya, Y. L., Kim, Y. S., Choksi, S., Morgan, M. J., Li, T., Liu, C., and Liu, Z. (2008) The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat. Immunol. 9, 1047-1054
26. Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J., and Walczak, H. (2011) Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471, 591-596
27. Hogue, D. L., Kerby, L., and Ling, V. (1999) A mammalian lysosomal membrane protein confers multidrug resistance upon expression in Saccharomyces cerevisiae. J. Biol. Chem. 274, 12877-12882
28. Li, Y., Zhang, Q., Tian, R., Wang, Q., Zhao, J. J., Iglehart, J. D., Wang, Z. C., and Richardson, A. L. (2011) Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res. 71, 7481-7489
29. Li, Y., Zou, L., Li, Q., Haibe-Kains, B., Tian, R., Li, Y., Desmedt, C., Sotiriou, C., Szallasi, Z., Iglehart, J. D., Richardson, A. L., and Wang, Z. C. (2010) Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat. Med. 16, 214-218
30. Hsu, H., Huang, J., Shu, H. B., Baichwal, V., and Goeddel, D. V. (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396
31. Seimiya, M., O-Wang, J., Bahar, R., Kawamura, K., Wang, Y., Saisho, H., and Tagawa, M. (2003) Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation. Elevated expression in human B lymphomas. Int. J. Oncol. 22, 301-304
32. Harvey, K. F., Shearwin-Whyatt, L. M., Fotia, A., Parton, R. G., and Kumar, S. (2002) N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J. Biol. Chem. 277, 9307-9317
33. Shearwin-Whyatt, L. M., Brown, D. L., Wylie, F. G., Stow, J. L., and Kumar, S. (2004) N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J. Cell Sci. 117, 3679-3689
34. Brudzewsky, D., Pedersen, A. E., Claesson, M. H., Gad, M., Kristensen, N. N., Lage, K., Jensen, T., Tommerup, N., Larsen, L. A., Knudsen, S., and Tümer, Z. (2009) Genome-wide gene expression profiling of SCID mice with T-cell-mediated colitis. Scand. J. Immunol. 69, 437-446
35. Myles, M. H., Dieckgraefe, B. K., Criley, J. M., and Franklin, C. L. (2007) Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial-induced inflammatory bowel disease. Inflamm. Bowel. Dis. 13, 822-836
36. Xavier, R. J., and Podolsky, D. K. (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434