A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ-Chain Degradation

Immunity

Volumn 29, Issue 1, 2008, Pages 33-43

  Ouchida, Rika ^a   Yamasaki, Sho ^a   Hikida, Masaki ^a   Masuda, Keiji ^a   Kawamura, Kiyoko ^b   Wada, Akihiko ^b   Mochizuki, Shigenobu ^b   Tagawa, Masatoshi ^b   Sakamoto, Akemi ^c   Hatano, Masahiko ^c   Tokuhisa, Takeshi ^c   Koseki, Haruhiko ^a   Saito, Takashi ^a   Kurosaki, Tomohiro ^a   Wang, Ji Yang ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b CHIBA CANCER CENTER   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

MOLIMMUNO

Indexed keywords

CD3 ANTIGEN; CD3DELTA ANTIGEN; CD3EPSILON ANTIGEN; CD3GAMMA ANTIGEN; CD3ZETA ANTIGEN; LYSOSOME PROTEIN; PROTEIN DERIVATIVE; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; CD4+ CD8+ T LYMPHOCYTE; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPLEEN; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANTIGENS, CD3; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMEDIATE-EARLY PROTEINS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 46749149984     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.04.024     Document Type: Article

References (36)

1. Adra C.N., Zhu S., Ko J.L., Guillemot J.C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.M., Rowley J.D., and Lim B. LAPTM5: A novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Genomics 35 (1996) 328-337
2. Bachmaier K., Krawczyk C., Kozieradzki I., Kong Y.Y., Sasaki T., Oliveira-dos-Santos A., Mariathasan S., Bouchard D., Wakeham A., Itie A., et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403 (2000) 211-216
3. Call M.E., and Wucherpfennig K.W. The T cell receptor: Critical role of the membrane environment in receptor assembly and function. Annu. Rev. Immunol. 23 (2005) 101-125
4. Chiang Y.J., Kole H.K., Brown K., Naramura M., Fukuhara S., Hu R.J., Jang I.K., Gutkind J.S., Shevach E., and Gu H. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403 (2000) 216-220
5. Colland F., Jacq X., Trouplin V., Mougin C., Groizeleau C., Hamburger A., Meil A., Wojcik J., Legrain P., and Gauthier J.M. Functional proteomics mapping of a human signaling pathway. Genome Res. 14 (2004) 1324-1332
6. D'Oro U., Munitic I., Chacko G., Karpova T., McNally J., and Ashwell J.D. Regulation of constitutive TCR internalization by the ζ-chain. J. Immunol. 169 (2002) 6269-6278
7. Geisler C. TCR trafficking in resting and stimulated T cells. Crit. Rev. Immunol. 24 (2004) 67-86
8. Hayami Y., Iida S., Nakazawa N., Hanamura I., Kato M., Komatsu H., Miura I., Dave B.J., Sanger W.G., Lim B., et al. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. Leukemia 17 (2003) 1650-1657
9. Hikida M., Johmura S., Hashimoto A., Takezaki M., and Kurosaki T. Coupling between B cell receptor and phospholipase C-γ2 is essential for mature B cell development. J. Exp. Med. 198 (2003) 581-589
10. Hofmann K., and Falquet L. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem. Sci. 26 (2001) 347-350
11. Holland S.J., Liao X.C., Mendenhall M.K., Zhou X., Pardo J., Chu P., Spencer C., Fu A., Sheng N., Yu P., et al. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. J. Exp. Med. 194 (2001) 1263-1276
12. + T cells by the Cbl family proteins. Immunity 25 (2006) 571-581
13. Kuhns M.S., Davis M.M., and Garcia K.C. Deconstructing the form and function of the TCR/CD3 complex. Immunity 24 (2006) 133-139
14. Liu H., Rhodes M., Wiest D.L., and Vignali D.A. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13 (2000) 665-675
15. Loreto M.P., Berry D.M., and McGlade C.J. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. Mol. Cell. Biol. 22 (2002) 4241-4255
16. Masuda K., Ouchida R., Hikida M., Kurosaki T., Yokoi M., Masutani C., Seki M., Wood R.D., Hanaoka F., and O-Wang J. DNA polymerases η and ζ function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J. Biol. Chem. 282 (2007) 17387-17394
17. Murphy M.A., Schnall R.G., Venter D.J., Barnett L., Bertoncello I., Thien C.B., Langdon W.Y., and Bowtell D.D. Tissue hyperplasia and enhanced T-cell signaling via ZAP-70 in c-Cbl-deficient mice. Mol. Cell. Biol. 18 (1998) 4872-4882
18. Myers M.D., Dragone L.L., and Weiss A. Src-like adaptor protein downregulates T cell receptor (TCR)-CD3 expression by targeting TCRζ for degradation. J. Cell Biol. 170 (2005) 285-294
19. Myers M.D., Sosinowski T., Dragone L.L., White C., Band H., Gu H., and Weiss A. Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat. Immunol. 7 (2006) 57-66
20. Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., Sekikawa K., Asano M., and Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17 (2002) 375-387
21. Naramura M., Kole H.K., Hu R.J., and Gu H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl. Acad. Sci. USA 95 (1998) 15547-15552
22. Naramura M., Jang I.K., Kole H., Huang F., Haines D., and Gu H. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR downmodulation. Nat. Immunol. 3 (2002) 1192-1199
23. Nosaka T., Kawashima T., Misawa K., Ikuta K., Mui A.L., and Kitamura T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18 (1999) 4754-4765
24. Pak Y., Glowacka W.K., Bruce M.C., Pham N., and Rotin D. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J. Cell Biol. 175 (2006) 631-645
25. Pandey A., Ibarrola N., Kratchmarova I., Fernandez M.M., Constantinescu S.N., Ohara O., Sawasdikosol S., Lodish H.F., and Mann M. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J. Biol. Chem. 277 (2002) 19131-19138
26. Rieux-Laucat F., Hivroz C., Lim A., Mateo V., Pellier I., Selz F., Fischer A., and Le Deist F. Inherited and somatic CD3ζ mutations in a patient with T-cell deficiency. N. Engl. J. Med. 354 (2006) 1913-1921
27. + severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex. Blood 109 (2007) 3198-3206
28. Schrum A.G., Turka L.A., and Palmer E. Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunol. Rev. 196 (2003) 7-24
29. Scott L.M., Mueller L., and Collins S.J. E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha. Blood 88 (1996) 2517-2530
30. Seimiya M., O-Wang J., Bahar R., Kawamura K., Wang Y., Saisho H., and Tagawa M. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: Elevated expression in human B lymphomas. Int. J. Oncol. 22 (2003) 301-304
31. Sosinowski T., Pandey A., Dixit V.M., and Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J. Exp. Med. 191 (2000) 463-474
32. + thymocytes and regulates positive selection. Immunity 15 (2001) 457-466
33. Valitutti S., Muller S., Salio M., and Lanzavecchia A. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185 (1997) 1859-1864
34. Viola A., and Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273 (1996) 104-106
35. Wang H.Y., Altman Y., Fang D., Elly C., Dai Y., Shao Y., and Liu Y.C. Cbl promotes ubiquitination of the T cell receptor ζ through an adaptor function of Zap-70. J. Biol. Chem. 276 (2001) 26004-26011
36. von Essen M., Bonefeld C.M., Siersma V., Rasmussen A.B., Lauritsen J.P., Nielsen B.L., and Geisler C. Constitutive and ligand-induced TCR degradation. J. Immunol. 173 (2004) 384-393