Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool

Journal of Proteome Research

Volumn 8, Issue 8, 2009, Pages 3951-3957

  Saxena, Chaitanya ^a   Bonacci, Tabetha M ^a   Huss, Karen L ^a   Bloem, Laura J ^a   Higgs, Richard E ^a   Hale, John E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Affinity chromatography; Bisindolylmaleimide III; Cell permeable peptide coupled small molecule; Chemical proteomics; Drug target deconvolution; GSK3 beta inhibitor; Mass spectrometry

Indexed keywords

5 CARBOXY FLUORESCEIN; BISINDOLYLMALEIMIDE 3; EPITOPE; FLUORESCEIN; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; HUMAN CELL; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEOMICS;

BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY, AFFINITY; DRUG DELIVERY SYSTEMS; FALSE POSITIVE REACTIONS; FLUORESCEIN; FLUORESCENT DYES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOLES; MALEIMIDES; MASS SPECTROMETRY; OLIGOPEPTIDES; PROTEINS; PROTEOMICS; REPRODUCIBILITY OF RESULTS;

EID: 68549083829     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900277x     Document Type: Article

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