Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells

Histology and Histopathology

Volumn 27, Issue 8, 2012, Pages 1079-1091

  Wang, Ping ^a,b   Mei, Juan ^b   Tao, Jing ^a   Zhang, Ning ^a   Tian, Hua ^a   Fu, Guo Hui ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b BENGBU MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Gastric carcinoma; Helicobacter pylori; Invasion; Proliferation; Ultrastructure

Indexed keywords

CADHERIN;

APOPTOSIS; ARTICLE; BACTERIUM ADHERENCE; CELL CYCLE; CELL JUNCTION; CELL MOTION; CELL ORGANELLE; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIUM; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST PATHOGEN INTERACTION; HUMAN; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; STOMACH; STOMACH TUMOR; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASTRUCTURE;

APOPTOSIS; BACTERIAL ADHESION; CADHERINS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIUM; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERCELLULAR JUNCTIONS; MICROSCOPY, ELECTRON, TRANSMISSION; ORGANELLES; STOMACH; STOMACH NEOPLASMS;

EID: 84864958586     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Al-Muhtaseb M.H., Abu-Khalaf A.M. and Aughsteen A.A.(2000). Ultrastructural study of the gastric mucosa and Helicobacter pylori in duodenal ulcer patients. Saudi Med. J. 21, 569-573
2. Amieva M.R., Salama N.R., Tompkins L.S. and Falkow S. (2002). Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells. Cell Microbiol. 4, 677-690.
3. Amieva M.R., Vogelmann R., Covacci, A., Tompkins L.S., Nelson W.J. and Falkow S. (2003). Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300, 1430-1434.
4. Andersen A.P., Elliott D.A., Lawson M., Barland P., Hatcher V.B. and Puszkin E.G. (1997). Growth and morphological transformations of Helicobacter pylori in broth media. J. Clin. Microbiol. 35, 2918-2922.
5. André A.R., Ferreira M.V., Mota R.M., Ferrasi A.C., Pardini M.I. and Rabenhorst S.H. (2010). Gastric adenocarcinoma and Helicobacter pylori: Correlation with p53 mutation and p27 immunoexpression. Cancer Epidemiol. 34, 618-625.
6. Björkholm B., Zhukhovitsky V., Löfman C., Hultén K., Enroth H., Block M., Rigo R., Falk P. and Engstrand L. (2000). Helicobacter pylori entry into human gastric epithelial cells: A potential determinant of virulence, persistence, and treatment failures. Helicobacter 5, 148-154.
7. Bland D.A., Suarez G., Beswick E.J., Sierra J.C. and Reyes V.E. (2006). H. pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response. World J. Gastroenterol. 12, 5306-5310
8. Caselli M., Aleotti A., Boldrini P., Ruina M. and Alvisi V. (1993). Ultrastructural patterns of Helicobacter pylori. Gut 34, 1507-1509.
9. Chan W.Y., Hui P.K., Leung K.M., Chow J., Kwok F. and Ng C.S. (1994). Coccoid forms of Helicobacter pylori in the human stomach. Am. J. Clin. Pathol. 102, 503-507.
10. Chen Y.C., Wang Y., Li J.Y., Xu W.R. and Zhang Y.L. (2006). H. pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade. World J. Gastroenterol. 12, 5972-5977.
11. Chiozzi V., Mazzini G., Oldani A., Sciullo A., Ventura U., Romano M., Boquet P. and Ricci V. (2009). Relationship between Vac A toxin and ammonia in Helicobacter pylori-induced apoptosis in human gastric epithelial cells. J. Physiol. Pharmacol. 60, 23-30.
12. Cho S.J., Kang N.S., Park S.Y., Kim B.O., Rhee D.K. and Pyo S. (2003). Induction of apoptosis and expression of apoptosis related genes in human epithelial carcinoma cells by Helicobacter pylori VacA toxin. Toxicon. 42, 61-111.
13. Chow K.W., Bank S., Ahn J., Roberts J., Blumstein M. and Kranz V. (1995). Helicobacter pylori infection does not increase gastric antrum mucosal cell proliferation. Am. J. Gastroenterol. 90, 64-66.
14. Chun H.J., Park D.K., Park C.H., Park J.H., Jeen Y.T., Um S.H., Lee S.W., Choi J.H., Kim C.D. and other authors (2002). Electron microscopic evaluation of adhesion of Helicobacter pylori to the gastric epithelial cells in chronic gastritis. Korean J. Intern. Med. 17, 45-50.
15. Cole S.P., Cirillo D., Kagnoff M.F., Guiney D.G. and Eckmann L. (1997). Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion. Infect. Immun. 65, 843-846.
16. Cover T.L. and Blanke S.R. (2005). Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat. Rev. Microbiol. 3, 320-332.
17. Cover T.L., Krishna U.S., Israel D.A. and Peek R.M. Jr (2003). Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res. 63, 951-957.
18. Dubois A. and Borén T. (2007). Helicobacter pylori is invasive and it may be a facultative intracellular organism. Cell Microbiol. 9, 1108-1116.
19. Evans D.G., Evans D.J. Jr and Graham D.Y. (1992). Adherence and internalization of Helicobacter pylori by HEp-2 cells. Gastroenterology 102, 1557-1567.
20. Galmiche A., Rassow J., Doye A., Cagnol S., Chambard J.C., ContaminS., de Thillot V., Just I., Ricci V., Solcia E., Van Obberghen E. and Boquet P. (2000). The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J. 19, 6361-6370.
21. Heczko U., Smith V.C., Mark Meloche R., Buchan A.M. and Finlay B.B. (2000). Characteristics of Helicobacter pylori attachment to human primary antral epithelial cells. Microbes Infect. 2, 1669-1676.
22. Keates S., Keates A.C., Katchar K., Peek R.M. Jr and Kelly C.P. (2007). Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J. Infect. Dis. 196, 95-103.
23. Konturek P.C., Konturek S. and Brzozowski T.J. (2006) Gastric cancer and Helicobacter pylori infection. Physiol. Pharmacol. 57 Suppl 3, 51-65.
24. Krueger S., Hundertmark T., Kalinski T., Peitz U., Wex T., Malfertheiner P., Naumann M., and Roessner A. (2006). Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK. J. Biol. Chem. 281, 2868-2875.
25. Kuck D., Kolmerer B., Iking-Konert C., Krammer P.H., Stremmel W. and Rudi J. (2001). Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS. Infect. Immun. 69, 5080-5087.
26. Kwok T., Backert S., Schwarz H., Berger J. and Meyer T.F. (2002). Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect. Immun. 70, 210821-20.
27. Lin C.S., He P.J., Hsu W.T., Wu M.S., Wu C.J., Shen H.W., Hwang C.H., Lai Y.K., Tsai N.M. and Liao K.W. (2010). Helicobacter pyloriderived Heat shock protein 60 enhances angiogenesis via a CXCR2-mediated signaling pathway. Biochem. Biophys Res. Commun. 397, 283-289.
28. Liu Z.F., Chen C.Y., Tang W., Zhang J.Y., Gong Y.Q. and Jia J.H. (2006). Gene-expression profiles in gastric epithelial cells stimulated with spiral and coccoid Helicobacter pylori. J. Med. Microbiol. 55, 1009-1015.
29. Lu H., Yamaoka Y. and Graham D.Y. (2005). Helicobacter pylori virulence factors: facts and fantasies. Curr. Opin. Gastroenterol. 21, 653-659.
30. Mangia A., Chiriatti A., Ranieri G., Abbate I., Coviello M., Simone G., Zito F.A., Montemurro S., Rucci A., Di Leo A., Tommasi S., Berloco P., Xu J.M. and Paradiso A. (2006). H pylori status and angiogenesis factors in human gastric carcinoma. World J. Gastroenterol. 12, 5465-5472
31. Marcos N.T., Magalhães A., Ferreira B., Oliveira M.J., Carvalho A.S., Mendes N., Gilmartin T., Head S.R., Figueiredo C., David L., Santos-Silva F. and Reis C.A. (2008). Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. J. Clin. Invest. 118, 2325-2336.
32. Mimuro H., Suzuki T., Nagai S., Rieder G., Suzuki M., Nagai T., Fujita Y., Nagamatsu K., Ishijima N., Koyasu S., Haas R. and Sasakawa C. (2007). Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe 2, 250-63.
33. Moss S.F., Sordillo E.M., Abdalla A.M., Makarov V., Hanzely Z., Perez-Perez G.I., Blaser M.J. and Holt P.R. (2001). Increased gastric epithelial cell apoptosis associated with colonization with cagA + Helicobacter pylori strains. Cancer Res. 61, 1406-1411.
34. Necchi V., Candusso M.E., Tava F., Luinetti O., Ventura U., Fiocca R., Ricci V. and Solcia E. (2007). Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology 132, 1009-1023.
35. Nilsson H.O., Blom J., Abu-Al-Soud W., Ljungh A.A., Andersen L.P. and Wadström T. (2002). Effect of cold starvation, acid stress, and nutrients on metabolic activity of Helicobacter pylori. Appl. Environ. Microbiol. 68, 11-9.
36. Oldani A., Cormont M., Hofman V., Chiozzi V., Oregioni O., Canonici A., Sciullo A., Sommi P., Fabbri A., Ricci V. and Boquet P. (2009). Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells. PLoS Pathog. 5, e1000603.
37. Ozbek A., Ozbek E., Dursun H., Kalkan Y. and Demirci T. (2010). Can Helicobacter pylori invade human gastric mucosa?: an in vivo study using electron microscopy, immunohistochemical methods, and realtime polymerase chain reaction. J. Clin. Gastroenterol. 44, 416-422.
38. Pearce H. R, Kalia N., Bardhan K.D., Atherton J. C and Brown N.J. (2004). Effects of Helicobacter pylori on endothelial cell proliferation and chemotaxis. Digestion 69, 201-210.
39. Petersen A.M. and Krogfelt K.A. (2003). Helicobacter pylori: an invading microorganism? A review. FEMS Immunol. Med. Microbiol. 36, 117-126.
40. Pilpilidis I., Kountouras J., Zavos, C. and Katsinelos P. (2011). Upper Gastrointestinal Carcinogenesis: H. pylori and Stem Cell Cross-Talk. J. Surg. Res. 166, 255-264.
41. Segal E.D., Falkow S. and Tompkins L.S. (1996). Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins. Proc. Natl. Acad. Sci. USA 93, 1259-1264.
42. Smoot D.T., Wynn Z., Elliott T.B., Allen C.R., Mekasha G., Naab T. and Ashktorab H. (1999). Effects of Helicobacter pylori on proliferation of gastric epithelial cells in vitro. Am. J. Gastroenterol. 94, 1508-1511.
43. Snider J.L. and Cardelli J.A. (2009). Helicobacter pylori induces cancer cell motility independent of the c-Met receptor. J. Carcinog. 8, 7.
44. Steele I.A., Dimaline R., Pritchard D.M., Peek R.M. Jr, Wang T.C., Dockray G.J. and Varro A. (2007). Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G347-354.
45. Tao R., Hu M.F., Lou J.T. and Lei Y.L. (2007). Effects of H pylori infection on gap-junctional intercellular communication and proliferation of gastric epithelial cells in vitro. World J. Gastroenterol. 13, 5497-5500.
46. Tegtmeyer N., Zabler D., Schmidt D., Hartig R., Brandt S. and Backert S. (2009). Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol. 11, 488-505.
47. Terebiznik M.R., Vazquez C.L., Torbicki K., Banks D., Wang T., Hong W., Blanke S. R., Colombo M.I. and Jones N.L. (2006). Helicobacter pylori VacA toxin promotes bacterial intracellular survival in gastric epithelial cells. Infect. Immun. 74, 6599-6614.
48. Terebiznik M.R., Raju D., Vázquez C.L., Torbricki K., Kulkarni R., Blanke S.R., Yoshimori T., Colombo M.I. and Jones N.L. (2009). Effect of Helicobacter pylori 's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy 5, 370-379.
49. Tomb J.F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A., Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B., Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K., Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.M., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M. and Venter J.C.(1997). The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547.
50. Tomimori K., Uema E., Teruya H., Ishikawa C., Okudaira T., Senba M., Yamamoto K., Matsuyama T., Kinjo F,. Fujita J. and Mori N. (2007). Helicobacter pylori induces CCL20 expression. Infect. Immun. 75, 5223-5232.
51. Willhite D.C., Cover T.L. and Blanke S.R. (2003). Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. J. Biol. Chem. 278, 48204-48209.
52. World Health Organization (1994). Schistosomes, liver flukes and Helicobacter pylori. IARC monographs on the evaluation of carcinogenic risks to human. IARC Monogr. Eval. Carcinog. Risks Hum. 61, 177-240.
53. Wu I.C., Wu M.T., Chen Y.K., Hsu M.C., Chou S.H., Lee C.H., Shiea J.T., Wu I.L., Huang C.T. and Wu D.C. (2008). Apoptotic effect of Helicobacter pylori on oesophageal squamous-cell carcinoma cells in vitro. Eur. J. Clin. Invest. 38, 760-765.
54. Xu C.X., Jia Y., Yang W.B., Zou H.F., Wang F. and Shen S.R. (2009). Effect of Helicobacter pylori on cell gap junction ultrastructure of gastric epithelial cells. Prog. Biochem. Biophys. 36, 722-728
55. Yamac D., Ayyildiz T., Coflkun U., Akyürek N., Dursun A., Seckin S. and Koybasioglu F. (2008). Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. Pathol. Res. Pract. 204, 527-536.
56. Zhang M.J., Meng F.L., Ji X.Y., He L.H. and Zhang J.Z. (2007) Adherence and invasion of mouse-adapted H pylori in different epithelial cell lines. World J. Gastroenterol. 13, 845-50.