Gastric adenocarcinoma and Helicobacter pylori: Correlation with p53 mutation and p27 immunoexpression

Cancer Epidemiology

Volumn 34, Issue 5, 2010, Pages 618-625

  André, Angela Rosa ^a   Ferreira, Márcia Valéria Pitombeira ^a   Mota, Rosa Maria Salani ^a   Ferrasi, Adriana Camargo ^b   Pardini, Maria Inês de Moura Campos ^b   Rabenhorst, Sílvia Helena Barem ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Gastric cancer; Helicobacter pylori; P27 Kip1 Protein; P53 genes; Tumor suppressor genes

Indexed keywords

CAGA PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B;

ADULT; AGED; ARTICLE; CANCER RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROPHORETIC MOBILITY; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH ADENOCARCINOMA; STOMACH CARCINOGENESIS; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; GENE SILENCING; GENES, P53; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; STOMACH NEOPLASMS; YOUNG ADULT;

EID: 77957236203     PISSN: 18777821     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canep.2010.05.005     Document Type: Article

References (81)

1. Konturek P.C., Konturek S.J., Brzozowski T. Gastric cancer and Helicobacter pylori infection. J Physiol Pharmacol 2006, 57(September (Suppl. 3)):51-65. [Review].
2. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965, 64:31-49.
3. Smith M.G., Hold G.L., Tahara E., El-Omar E.M. Cellular and molecular aspects of gastric cancer. World J Gastroenterol 2006, 12(May (19)):2979-2990. [Review].
4. Crew K.D., Neugut A.I. Epidemiology of gastric cancer. World J Gastroenterol 2006, 12(January (3)):354-362. [Review].
5. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum (Lyon) 1994, 61(June):1-241. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.
6. Parsonnet J. Bacterial infection as a cause of cancer. Environ Health Perspect 1995, 103(November (8)):263-268. [Review. Erratum in: Environ Health Perspect 1996;104(May (Suppl. 3))].
7. Konturek P.C., Kania J., Konturek J.W., Nikiforuk A., Konturek S.J., Hahn E.G. H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. Med Sci Monit 2003, 9(July (7)):SR53-SR66. [Review].
8. van Doorn N.E., van Rees E.P., Namavar F., de Graaff J. Local cellular immune response in the acute phase of gastritis in mice induced chemically and by Helicobacter pylori. J Med Microbiol 1998, 47(October (10)):863-870.
9. Figueiredo C., Machado J.C., Yamaoka Y. Pathogenesis of Helicobacter pylori Infection. Helicobacter 2005, 10(Suppl. 1):14-20. [Review].
10. Yao Y., Tao H., Park D.I., Sepulveda J.L., Sepulveda A.R. Demonstration and characterization of mutations induced by Helicobacter pylori organisms in gastric epithelial cells. Helicobacter 2006, 11(August (4)):272-286.
11. Ortega S., Malumbres M., Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 2002, 1602(March (1)):73-87. [Review].
12. Ono Y., Tamiya T., Ichikawa T., Matsumoto K., Furuta T., Ohmoto T., et al. Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression. Acta Neuropathol 1997, 94(July (1)):21-27.
13. Kountouras J., Zavos C., Chatzopoulos D., Katsinelos P. New aspects of Helicobacter pylori infection involvement in gastric oncogenesis. J Surg Res 2008, 146(May (1)):149-158. [Review].
14. Lloyd R.V., Erickson L.A., Jin L., Kulig E., Qian X., Cheville J.C., et al. p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 1999, 154(February (2)):313-323. [Review].
15. Sandhu C., Slingerland J. Deregulation of the cell cycle in cancer. Cancer Detect Prev 2000, 24(2):107-118. [Review].
16. So J.B., Samarasinge K., Raju G.C., Moochhala S.M., Ti T.K. Expression of cell-cycle regulators p27 and cyclin E correlates with survival in gastric carcinoma patients. J Surg Res 2000, 94(November (1)):56-60.
17. Chetty R p27 Protein and cancers of the gastrointestinal tract and liver: an overview. J Clin Gastroenterol 2003, 37(July (1)):23-27. [Review].
18. Kim D.H. Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer. Yonsei Med J 2007, 48(August (4)):694-700.
19. Yasui W., Kudo Y., Semba S., Yokozaki H., Tahara E. Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas. Jpn J Cancer Res 1997, 88(July (7)):625-629.
20. Tsihlias J., Kapusta L., Slingerland J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu Rev Med 1999, 50:401-423. [Review].
21. Ito R., Yasui W., Ogawa Y., Toyosawa S., Tahara E., Ijuhin N. Reduced expression of cyclin-dependent kinase inhibitor p27(Kip1) in oral malignant tumors. Pathobiology 1999, 67(July-August (4)):169-173.
22. Ho A., Dowdy S.F. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr Opin Genet Dev 2002, 12(February (1)):47-52. [Review].
23. Lei P.P., Zhang Z.J., Shen L.J., Li J.Y., Zou Q., Zhang H.X. Expression and hypermethylation of p27 kip1 in hepatocarcinogenesis. World J Gastroenterol 2005, 11(August (29)):4587-4591.
24. Lan J., Xiong Y.Y., Lin Y.X., Wang B.C., Gong L.L., Xu H.S., et al. Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. World J Gastroenterol 2003, 9(January (1)):54-58.
25. Kim J.H., Takahashi T., Chiba I., Park J.G., Birrer M.J., Roh J.K., et al. Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines. J Natl Cancer Inst 1991, 83(July (13)):938-943.
26. Uchino S., Noguchi M., Ochiai A., Saito T., Kobayashi M., Hirohashi S. p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer. Int J Cancer 1993, 54(July (5)):759-764.
27. Li J.H., Shi X.Z., Lv S., Liu M., Xu G.W. Effect of Helicobacter pylori infection on p53 expression of gastric mucosa and adenocarcinoma with microsatellite instability. World J Gastroenterol 2005, 11(July (28)):4363-4366.
28. Shibata A., Parsonnet J., Longacre T.A., Garcia M.I., Puligandla B., Davis R.E., et al. CagA status of Helicobacter pylori infection and p53 gene mutations in gastric adenocarcinoma. Carcinogenesis 2002, 23(March (3)):419-424.
29. Yu J., Leung W.K., Ng E.K., To K.F., Ebert M.P., Go M.Y., et al. Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia. Aliment Pharmacol Ther 2001, 15(September (9)):1505-1511.
30. Liu X.P., Kawauchi S., Oga A., Suehiro Y., Tsushimi K., Tsushimi M., et al. Combined examination of p27(Kip1), p21(Waf1/Cip1) and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma. Histopathology 2001, 39(December (6)):603-610.
31. Targa A.C., César A.C., Cury P.M., Silva A.E. Apoptosis in different gastric lesions and gastric cancer: relationship with Helicobacter pylori, overexpression of p53 and aneuploidy. Genet Mol Res 2007, 6(September (3)):554-565.
32. Foster G.D., Twell D. Plant gene isolation. Principles and practice 1996, John Wiley & Sons Ltd., Chichester, England, p. 426.
33. Lage A.P., Godfroid E., Fauconnier A., Burette A., Butzler J.P., Bollen A., et al. Diagnosis of Helicobacter pylori infection by PCR: comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens. J Clin Microbiol 1995, 33(October (10)):2752-2756.
34. Covacci A., Rappuoli R. PCR amplifications of H. pylori gene sequences. Helicobacter pylori: techniques for clinical diagnosis 1996, 94-111. W.B. Saunders Company Ltd., London, United Kingdom. A. Lee, F. Megraud (Eds.).
35. Sanguinetti C.J., Dias Neto E., Simpson A.J. Rapid silver staining and recovery of PCR products separated on polyacrylamide gels. Biotechniques 1994, 17(November (5)):914-921.
36. Hsu S.M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981, 29(April (4)):577-580.
37. Kudo Y., Takata T., Yasui W., Ogawa I., Miyauchi M., Takekoshi T., et al. Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is an indicator of malignant behavior in oral squamous cell carcinoma. Cancer 1998, 83(December (12)):2447-2455.
38. Murakami Y., Suzuki Y., Kishimoto Y., Hirohashi S., Hayashi K., Sekiya T. Detection of DNA aberrations in human cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. Tohoku J Exp Med 1992, 168(October (2)):247-255.
39. Brazil, Ministry of Health-Brazilian National Cancer Institute - INCA Care cancer coordination. Estimativas 2010: Incidência de câncer no Brasil 2009, INCA, Rio de janeiro, RJ, Available from: http://www.inca.gov.br/estimativa/2010 [accessed 28.04.10].
40. Han S., Kim H.Y., Park K., Lee M.S., Kim H.J., Kim Y.D. Expression of p27Kip1 and cyclin D1 proteins is inversely correlated and is associated with poor clinical outcome in human gastric cancer. J Surg Oncol 1999, 71(July (3)):147-154.
41. Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994, 54(September (18)):4855-4878. [Review].
42. Fenoglio-Preiser C.M., Wang J., Stemmermann G.N., Noffsinger A. TP53 and gastric carcinoma: a review. Hum Mutat 2003, 21(March (3)):258-270. [Review].
43. Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., et al. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1991, 88(June (12)):5413-5417.
44. Condie A., Eeles R., Borresen A.L., Coles C., Cooper C., Prosser J. Detection of point mutations in the p53 gene: comparison of single-strand conformation polymorphism, constant denaturant gel electrophoresis, and hydroxylamine and osmium tetroxide techniques. Hum Mutat 1993, 2(1):58-66.
45. Munirajan A.K., Tutsumi-Ishii Y., Mohanprasad B.K., Hirano H., Munakata N., Shanmugam G., et al. p53 gene mutations in oral carcinomas from India. Int J Cancer 1996, 66(May (3)):297-300.
46. Vidaurreta M., Maestro M.L., Sanz-Casla M.T., Rafael S., Veganzones S., de la Orden V., et al. Colorectal carcinoma prognosis can be predicted by alterations in gene p53 exons 5 and 8. Int J Colorectal Dis 2008, 23(June (6)):581-586.
47. Murtaza I., Mushtaq D., Margoob M.A., Dutt A., Wani N.A., Ahmad I., et al. A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. World J Gastroenterol 2006, 12(July (25)):4033-4037.
48. Bahnassy A.A., Zekri A.R., Abdallah S., El-Shehaby A.M., Sherif G.M. Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival. Pathol Int 2005, 55(February (2)):53-62.
49. Wang J.Y., Hsieh J.S., Chen C.C., Tzou W.S., Cheng T.L., Chen F.M., et al. Alterations of APC, c-met, and p53 genes in tumor tissue and serum of patients with gastric cancers. J Surg Res 2004, 120(August (2)):242-248.
50. Phatak P., Selvi S.K., Divya T., Hedge S., Somasundaram K. Alterations in tumour suppressor gene p53 in human gliomas from Indian patients. J Biosci 2002, 27(December (7)):673-678.
51. Klumb C.E., de Resende L.M., Tajara E.H., Bertelli E.C., Rumjanek V.M., Maia R.C. p53 gene analysis in childhood B non-Hodgkin's lymphoma. Sao Paulo Med J 2001, 119(November (6)):212-215.
52. Pinheiro N.A., Villa L.L. Low frequency of p53 mutations in cervical carcinomas among Brazilian women. Braz J Med Biol Res 2001, 34(June (6)):727-733.
53. Hiranuma H., Jikko A., Maeda T., Matumura S., Murakami S., Fukuda Y., et al. An analysis of the prognostic significance of p53 status for squamous cell carcinoma of the oral cavity treated by radiotherapy. Oral Oncol 1998, 34(November (6)):513-518.
54. Nylander K., Schildt E.B., Eriksson M., Magnusson A., Mehle C., Roos G. A non-random deletion in the p53 gene in oral squamous cell carcinoma. Br J Cancer 1996, 73(June (11)):1381-1386.
55. Nagai M.A., Miracca E.C., Yamamoto L., Kowalski L.P., Brentani R.R. TP53 mutations in upper aerodigestive squamous cell carcinomas from a group of Brazilian patients. Am J Surg 1995, 170(November (5)):492-494.
56. Wang J., Chi D.S., Kalin G.B., Sosinski C., Miller L.E., Burja I., et al. Helicobacter pylori infection and oncogene expressions in gastric carcinoma and its precursor lesions. Dig Dis Sci 2002, 47(January (1)):107-113.
57. Jacks T., Weinberg R.A. The expanding role of cell cycle regulators. Science 1998, 280(May (5366)):1035-1036.
58. Koff A. How to decrease p27Kip1 levels during tumor development. Cancer Cell 2006, 9(February (2)):75-76.
59. Yasui W., Oue N., Kuniyasu H., Ito R., Tahara E., Yokozaki H. Molecular diagnosis of gastric cancer: present and future. Gastric Cancer 2001, 4(3):113-121. [Review].
60. Kim D.H., Lee H.I., Nam E.S., Shin H.S., Sohn J.H., Park C.H., et al. Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma. Histopathology 2000, 36(March (3)):245-251.
61. Sgambato A., Migaldi M., Leocata P., Ventura L., Criscuolo M., Di Giacomo C., et al. Loss of p27Kip1 expression is a strong independent prognostic factor of reduced survival in N0 gastric carcinomas. Cancer 2000, 89(December (11)):2247-2257.
62. Thomazini C.M., Pinheiro N.A., Pardini M.I., Naresse L.E., Rodrigues M.A. Infecção por Helicobacter pylori e câncer gástrico: freqüência de cepas patogênicas cagA e vacA em pacientes com câncer gástrico. J Bras Patol Med Lab 2006, 42(February (1)):25-30.
63. Evans D.G., Queiroz D.M., Mendes E.N., Evans D.J. Helicobacter pylori cagA status and s and m alleles of vacA in isolates from individuals with a variety of H. pylori-associated gastric diseases. J Clin Microbiol 1998, 36(November (11)):3435-3437.
64. Gatti L.L., Módena J.L., Payão S.L., Smith Mde A., Fukuhara Y., Módena J.L., et al. Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. Acta Trop 2006, 100(December (3)):232-240.
65. Ekström A.M., Held M., Hansson L.E., Engstrand L., Nyrén O. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology 2001, 121(October (4)):784-791.
66. Nomura A., Stemmermann G.N., Chyou P.H., Kato I., Perez-Perez G.I., Blaser M.J. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991, 325(October (16)):1132-1136.
67. Ashour A.A., Magalhães P.P., Mendes E.N., Collares G.B., de Gusmão V.R., Queiroz D.M., et al. Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma. FEMS Immunol Med Microbiol 2002, 33(July (3)):173-178.
68. Ribeiro M.L., Godoy A.P., Benvengo Y.H., Mendonça S., Pedrazzoli J. Clinical relevance of the cagA, vacA and iceA genotypes of Helicobacter pylori in Brazilian clinical isolates. FEMS Immunol Med Microbiol 2003, 36(May (3)):181-185.
69. Chang C.S., Chen W.N., Lin H.H., Wu C.C., Wang C.J. Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma. World J Gastroenterol 2004, 10(August (15)):2232-2240.
70. Gatti L.L., Fagundes e Souza E.K., Leite K.R., Bastos E.L., Vicentini L.R., Silva L.C., et al. cagA vacA alleles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients. Diagn Microbiol Infect Dis 2005, 51(April (4)):231-235.
71. Deguchi R., Takagi A., Kawata H., Inoko H., Miwa T. Association between CagA+ Helicobacter pylori infection and p53, bax and transforming growth factor-beta-RII gene mutations in gastric cancer patients. Int J Cancer 2001, 91(February (4)):481-485.
72. Berloco P., Russo F., Cariola F., Gentile M., Giorgio P., Caruso M.L., et al. Low presence of p53 abnormalities in H. pylori-infected gastric mucosa and in gastric adenocarcinoma. J Gastroenterol 2003, 38(1):28-36.
73. Magalhães P.P., Queiroz D.M., Camargo A.A., Simpson A.J. CagA status of Helicobacter pylori infection and p53 gene mutations in gastric adenocarcinoma. Carcinogenesis 2003, 24(January (1)):145. [Author reply 147].
74. Yamaoka Y., Kodama T., Kashima K., Graham D.Y., Sepulveda A.R. Variants of the 3' region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases. J Clin Microbiol 1998, 36(August (8)):2258-2263.
75. Rota C.A., Pereira-Lima J.C., Blaya C., Nardi N.B. Consensus and variable region PCR analysis of Helicobacter pylori 3' region of cagA gene in isolates from individuals with or without peptic ulcer. J Clin Microbiol 2001, 39(February (2)):606-612.
76. Eguchi H., Herschenhous N., Kuzushita N., Moss S.F. Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells. Cancer Res. 2003, 63(August (15)):4739-4746.
77. Kim S.S., Meitner P., Konkin T.A., Cho Y.S., Resnick M.B., Moss S.F. Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis. Mod Pathol. 2006, 19(January (1)):49-58.
78. Shirin H., Sordillo E.M., Kolevska T.K., Hibshoosh H., Kawabata Y., Oh S.H., et al. Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1). Infect Immun 2000, 68(September (9)):5321-5328.
79. Eguchi H., Carpentier S., Kim S.S., Moss S.F. P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori. Gut 2004, 53(June (6)):797-804.
80. Lin Y.F., Wu M.S., Chang C.C., Lin S.W., Lin J.T., Sun Y.J., et al. Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer. Mol Cell Proteomics 2006, 5(August (8)):1484-1496.
81. Al-Moundhri M.S., Nirmala V., Al-Hadabi I., Al-Mawaly K., Burney I., Al-Nabhani M., et al. The prognostic significance of p53, p27 kip1, p21 waf1, HER-2/neu, and Ki67 proteins expression in gastric cancer: a clinicopathological and immunohistochemical study of 121 Arab patients. J Surg Oncol 2005, 91(September (4)):243-252.